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Mouse Myeloperoxidase DuoSet ELISA, 15 Plate

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
Biotin

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Mouse Myeloperoxidase DuoSet ELISA, 15 Plate Summary

Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Mpo

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY3667.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Myeloperoxidase DuoSet ELISA, 15 Plate

  • EC 1.11.1
  • EC 1.11.1.7
  • MPO
  • Myeloperoxidase

Background

Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxide dependent formation of hypochlorus acid (HOCl) and other reactive species. Enzymatically active MPO is a disulfide-linked tetramer that contains two heme groups and two copies each of the heavy and light chains. MPO binds Albumin, MMR, Cytokeratin 1 on vascular endothelial cells, HMW Kininogen, and Integrin CD11b/CD18 on neutrophils. These interactions promote MPO clearance, a reduction of nitric oxide and bradykinin levels, reduced vasodilation, and continued neutrophil activation. Neutrophil MPO is stored in cytoplasmic azurophilic granules. Upon cellular activation and degranulation, MPO is delivered into phagosomes where it is required for the killing of phagocytosed bacteria. Activated neutrophils also release granule contents extracellularly. Elevated plasma MPO levels have been associated with a variety of clinical conditions including systemic inflammation, eclampsia, risk of cardiovascular events, vascular endothelial dysfunction, severity of multiple sclerosis, and prospective mortality and oxidative stress during hemodialysis.

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Publications for Myeloperoxidase/MPO (DY3667)(84)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Mouse.


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All Applications
Filter By Species
Human
(1)
Mouse
(78)
Rat
(3)
Transgenic Mouse
(3)
All Species
Showing Publications 1 - 10 of 84. Show All 84 Publications.
Publications using DY3667 Applications Species
Das, S;Kaminski, TW;Schlegel, BT;Bain, W;Hu, S;Patel, A;Kale, SL;Chen, K;Lee, JS;Mallampalli, RK;Kagan, VE;Rajasundaram, D;McVerry, BJ;Sundd, P;Kitsios, GD;Ray, A;Ray, P; Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure Nature communications 2024-06-03 [PMID: 38830855] (Mouse) Mouse
Kim, YY;Hur, G;Jang, HJ;Jeong, S;Lee, SW;Lee, SJ;Rho, MC;Kim, SH;Lee, S; Ferulic Acid Derivatives Ameliorate Intestine Barrier Destruction by Alleviating Inflammatory Responses in Dextran Sulfate Sodium-Induced Inflammatory Bowel Disease Toxics 2024-04-03 [PMID: 38668491] (Mouse) Mouse
Zeng, FL;Zhang, Y;Wang, ZH;Zhang, H;Meng, XT;Wu, YQ;Qian, ZZ;Ding, YH;Li, J;Ma, TT;Huang, C; Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2 Acta pharmacologica Sinica 2024-04-08 [PMID: 38589685] (Mouse) Mouse
Fulte, S;Atto, B;McCarty, A;Horn, KJ;Redzic, JS;Eisenmesser, E;Yang, M;Marsh, RL;Tristram, S;Clark, SE; Heme sequestration by hemophilin from Haemophilus haemolyticus reduces respiratory tract colonization and infection with non-typeable Haemophilus influenzae mSphere 2024-02-21 [PMID: 38380941] (Mouse) Mouse
Andreev, D;Kachler, K;Liu, M;Chen, Z;Krishnacoumar, B;Ringer, M;Frey, S;Krönke, G;Voehringer, D;Schett, G;Bozec, A; Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase Nature communications 2024-02-05 [PMID: 38316791] (Transgenic Mouse) Transgenic Mouse
Pandey, N;Kaur, H;Chandaluri, L;Anand, SK;Chokhawala, H;Magdy, T;Stokes, KY;Orr, AW;Rom, O;Dhanesha, N; CD14 Blockade Does Not Improve Outcomes of Deep Vein Thrombosis Following Inferior Vena Cava Stenosis in Mice bioRxiv : the preprint server for biology 2024-01-12 [PMID: 38260582] (Mouse) Mouse
Cao, F;Chen, G;Xu, Y;Wang, X;Tang, X;Zhang, W;Song, X;Yang, X;Zeng, W;Xie, J; METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner Cell death & disease 2024-01-13 [PMID: 38218935] (Mouse) Mouse
Edgerton, M;Rojas, I;Kumar, R;Li, R;Salvatori, O;Abrams, S;Irimia, D; Neutrophil swarms containing myeloid-derived suppressor cells are crucial for limiting oral mucosal infection by C. albicans Research square 2023-10-09 [PMID: 37886517] (Mouse) Mouse
Joo, MK;Shin, YJ;Kim, DH; Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice Scientific reports 2023-09-19 [PMID: 37726354] (Mouse) Mouse
Wang, S;Ruan, P;Peng, L;Wang, J; Cytokine-stimulated human amniotic epithelial cells alleviate DSS-induced colitis in mice through anti-inflammation and regulating Th17/Treg balance International immunopharmacology 2023-05-15 [PMID: 37196557] (Mouse) Mouse
Show All 84 Publications.

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Bioinformatics

Gene Symbol Mpo