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LSD1 Antibody [PE]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IP, ChIP
Clonality
Polyclonal
Host
Rabbit
Conjugate
PE

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-536AF350
Alexa Fluor 405
NB100-536AF405
Alexa Fluor 488
NB100-536AF488
Alexa Fluor 532
NB100-536AF532
Alexa Fluor 594
NB100-536AF594
Alexa Fluor 647
NB100-536AF647
Alexa Fluor 700
NB100-536AF700
Alexa Fluor 750
NB100-536AF750
Allophycocyanin
NB100-536APC
Biotin
NB100-536B
CoraFluor 1
NB100-536CL1
DyLight 350
NB100-536UV
DyLight 405
NB100-536V
DyLight 488
NB100-536G
DyLight 550
NB100-536R
DyLight 594
NB100-536DL594
DyLight 650
NB100-536C
DyLight 680
NB100-536FR
DyLight 755
NB100-536IR
FITC
NB100-536F
HRP
NB100-536H
Janelia Fluor 525
NB100-536JF525
Janelia Fluor 549
NB100-536JF549
Janelia Fluor 585
NB100-536JF585
Janelia Fluor 635
NB100-536JF635
Janelia Fluor 646
NB100-536JF646
Janelia Fluor 669
NB100-536JF669
PerCP
NB100-536PCP
Unconjugated
NB100-536
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LSD1 Antibody [PE] Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residues 50 and 100 of human FAD-binding protein BRAF35-HDAC complex 110 kDa using the numbering given in TrEMBL entry O60341 (GeneID 23028).
Marker
Nucleus Marker
Specificity
NB100-536 is specific for human BHC110-KIAA0601 protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KDM1A
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Chromatin Immunoprecipitation (ChIP)
  • Chromatin Immunoprecipitation Sequencing
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for LSD1 Antibody [PE]

  • amine oxidase (flavin containing) domain 2
  • AOF2
  • AOF2lysine-specific histone demethylase 1
  • BHC110
  • BHC110FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
  • Flavin-containing amine oxidase domain-containing protein 2
  • KIAA0601KDM1
  • LSD1
  • LSD1BRAF35-HDAC complex protein BHC110
  • lysine (K)-specific demethylase 1
  • Lysine (K)specific Demethylase 1A
  • Lysine (K)-specific Demethylase 1A
  • lysine-specific histone demethylase 1A

Background

LSD1 a recently identified, first known lysine-specific histone demethylase, is an 886 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys-4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that it plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (might use alternative electron acceptors). Along with nuclear FHL2 it serves as a novel biomarker predictive for prostate cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol KDM1A