Latent TGF-beta bp4 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LTBP-4 is a 170 kDa extracellular glycoprotein that belongs to the LTBP/fibrillin family. These proteins contain a conserved pattern of eight cysteine residues (8Cys) and EGF-like domains. Mouse LTBP-4 isoform 1 is synthesized as 1666 amino acid residues and contains 14 EGF-like motifs and three 8Cys, the 3^rd of which is responsible for disulfide-association with the latency-linked associated peptide (LAP) of latent TGF-beta 1. LTBP-4 is expressed in multiple tissues and is involved in the assembly, secretion and targeting of latent TGF-beta to sites where it can be activated. Two additional splice isoforms that differ from isoform 1 in residues 60‑150 or 67‑150, have been described. Human and mouse LTBP-4 share 90% amino acid sequence homology.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: ICC, IHC, Western Blot.

Showing Publications 1 - 7 of 7.

Publications using AF2885	Applications	Species
Beaufort, N;Ingendahl, L;Merdanovic, M;Schmidt, A;Podlesainski, D;Richter, T;Neumann, T;Kuszner, M;Vetter, IR;Stege, P;Burston, SG;Filipovic, A;Ruiz-Blanco, YB;Bravo-Rodriguez, K;Mieres-Perez, J;Beuck, C;Uebel, S;Zobawa, M;Schillinger, J;Malik, R;Todorov-Völgyi, K;Rey, J;Roberti, A;Hagemeier, B;Wefers, B;Müller, SA;Wurst, W;Sanchez-Garcia, E;Zimmermann, A;Hu, XY;Clausen, T;Huber, R;Lichtenthaler, SF;Schmuck, C;Giese, M;Kaiser, M;Ehrmann, M;Dichgans, M; Rational correction of pathogenic conformational defects in HTRA1 Nature communications 2024-07-16 [PMID: 39013852] (Western Blot, Mouse)	Western Blot	Mouse
CT Su, TM Jao, Z Urban, YJ Huang, DHW See, YC Tsai, WC Lin, JW Huang LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure Cell Death & Disease, 2021-10-13;12(10):943. 2021-10-13 [PMID: 34645813] (Western Blot, Mouse)	Western Blot	Mouse
A Schiavinat, DR Keene, T Imhof, R Doliana, T Sasaki, G Sengle Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts Sci Rep, 2017-07-17;7(1):5526. 2017-07-17 [PMID: 28717224] (ICC, Mouse)	ICC	Mouse
Y Fujikawa, H Yoshida, T Inoue, T Ohbayashi, K Noda, H von Melchn, T Iwasaka, I Shiojima, TO Akama, T Nakamura Latent TGF-? binding protein 2 and 4 have essential overlapping functions in microfibril development Sci Rep, 2017-03-02;7(0):43714. 2017-03-02 [PMID: 28252045] (ICC, Mouse)	ICC	Mouse
Bultmann-Mellin I, Conradi A, Maul A, Dinger K, Wempe F, Wohl A, Imhof T, Wunderlich F, Bunck A, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms. Dis Model Mech, 2015-02-20;8(4):403-15. 2015-02-20 [PMID: 25713297] (ICC, IHC, Western Blot, Mouse)	ICC, IHC, Western Blot	Mouse
Noda K, Dabovic B, Takagi K, Inoue T, Horiguchi M, Hirai M, Fujikawa Y, Akama T, Kusumoto K, Zilberberg L, Sakai L, Koli K, Naitoh M, von Melchner H, Suzuki S, Rifkin D, Nakamura T Latent TGF-beta binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5. Proc Natl Acad Sci U S A, 2013-02-04;110(8):2852-7. 2013-02-04 [PMID: 23382201] (IHC, Mouse)	IHC	Mouse
Hosui A, Kimura A, Yamaji D, Zhu BM, Na R, Hennighausen L Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation. J. Exp. Med., 2009-03-30;206(4):819-31. 2009-03-30 [PMID: 19332876] (ICC, Western Blot, Mouse)	ICC, Western Blot	Mouse

Array AF2885

• Latent TGF-beta bp4 Antibodies
• Latent TGF-beta bp4 Proteins and Enzyme