KLF5 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human KLF5, also known as basic transcription element binding protein 2 (BTEB2), is a widely expressed 51 kDa (457 aa) member of the kruppel C2H2-type zinc finger protein family. KLF5 contains three C2H2-type zinc fingers at the carboxyl-terminus that preferentially bind to cis-DNA elements that are GC rich. It is a transcription activator that promotes cell proliferation and oncogenesis. Over the region used as immunogen, human, mouse and canine KLF5 share 95% aa sequence identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 7 applications: ChIP, ICC, IHC, IHC-P, Immunoprecipitation, Western Blot, mmunoprecipitation.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using AF3758	Applications	Species
Alavi, M;Mejia-Bautista, A;Tang, M;Bandovic, J;Rosenberg, AZ;Bialkowska, AB; Krüppel-like Factor 5 Plays an Important Role in the Pathogenesis of Chronic Pancreatitis Cancers 2023-11-15 [PMID: 38001687] (IHC, Mouse)	IHC	Mouse
P Zhao, J Sun, X Huang, X Zhang, X Liu, R Liu, G Du, W Gan, C Yang, Y Tang, C Chen, D Jiang Targeting the KLF5-EphA2 axis can restrain cancer stemness and overcome chemoresistance in basal-like breast cancer International journal of biological sciences, 2023-03-21;19(6):1861-1874. 2023-03-21 [PMID: 37063424] (Western Blot, ChIP, Human)	Western Blot, ChIP	Human
Q Wu, Z Liu, Z Gao, Y Luo, F Li, C Yang, T Wang, X Meng, H Chen, J Li, Y Kong, C Dong, S Sun, C Chen KLF5 inhibition potentiates anti-PD1 efficacy by enhancing CD8+ T-cell-dependent antitumor immunity Theranostics, 2023-02-21;13(4):1381-1400. 2/21/2023 [PMID: 36923542]
Keisuke Fukuchi, Kayoko Nanai, Hiroshi Yuita, Chikako Maru, Jun Tsukada, Masato Ishigami et al. Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals Journal of Oncology 11/4/2022 [PMID: 36385956]
Y Kong, W Ren, H Fang, NA Shah, Y Shi, D You, C Zhou, D Jiang, C Yang, H Liang, W Liu, L Wang, W Gan, X Wan, F Li, Z Li, C Chen, N Xie Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer International journal of biological sciences, 2022-02-28;18(5):2104-2115. 2022-02-28 [PMID: 35342356] (Western Blot, Human)	Western Blot	Human
S Huang, P Kuri, Y Aubert, M Brewster, N Li, O Farrelly, G Rice, H Bae, S Prouty, T Dentchev, W Luo, BC Capell, P Rompolas Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization Cell Stem Cell, 2021-06-07;0(0):. 2021-06-07 [PMID: 34102139] (IHC, Mouse)	IHC	Mouse
J Li, B Zhang, M Liu, X Fu, X Ci, J A, C Fu, G Dong, R Wu, Z Zhang, L Fu, JT Dong KLF5 Is Crucial for Androgen-AR Signaling to Transactivate Genes and Promote Cell Proliferation in Prostate Cancer Cells Cancers (Basel), 2020-03-21;12(3):. 2020-03-21 [PMID: 32245249] (ChIP, Human)	ChIP	Human
NJ Hogrebe, P Augsornwor, KG Maxwell, L Velazco-Cr, JR Millman Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells Nat. Biotechnol., 2020-02-24;0(0):. 2020-02-24 [PMID: 32094658] (ICC, Human)	ICC	Human
Y Ge, Y Miao, S Gur-Cohen, N Gomez, H Yang, M Nikolova, L Polak, Y Hu, A Verma, O Elemento, JG Krueger, E Fuchs The aging skin microenvironment dictates stem cell behavior Proc. Natl. Acad. Sci. U.S.A., 2020-02-24;0(0):. 2020-02-24 [PMID: 32094197] (IHC, Mouse)	IHC	Mouse
Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells Nat. Immunol., 2020-02-17;21(3):274-286. 2020-02-17 [PMID: 32066947] (ICC, Human)	ICC	Human
CK Kim, M Saxena, K Maharjan, JJ Song, KR Shroyer, AB Bialkowska, RA Shivdasani, VW Yang Kr�ppel-like factor 5 regulates stemness, lineage specification, and regeneration of intestinal epithelial stem cells Cell Mol Gastroenterol Hepatol, 2019-11-25;0(0):. 11/25/2019 [PMID: 31778829]
Y Wu, J Qin, F Li, C Yang, Z Li, Z Zhou, H Zhang, Y Li, X Wang, R Liu, Q Tao, W Chen, C Chen USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5 J. Biol. Chem., 2019-10-17;0(0):. 2019-10-17 [PMID: 31624151] (Immunoprecipitation, Human)	Immunoprecipitation	Human
R Tao, B Zhang, Y Li, JL King, R Tian, S Xia, CR Schiavon, JT Dong HDAC-mediated deacetylation of KLF5 associates with its proteasomal degradation Biochem. Biophys. Res. Commun., 2018-04-24;0(0):. 2018-04-24 [PMID: 29679567] (Immunoprecipitation, mmunoprecipitation, Human)	Immunoprecipitation, mmunoprecipitation	Human
Y Ge, NC Gomez, RC Adam, M Nikolova, H Yang, A Verma, CP Lu, L Polak, S Yuan, O Elemento, E Fuchs Stem Cell Lineage Infidelity Drives Wound Repair and Cancer Cell, 2017-04-20;0(0):. 2017-04-20 [PMID: 28434617] (IHC, Mouse)	IHC	Mouse
W Zhang, S Hong, KP Maniar, S Cheng, C Jie, AW Rademaker, AM Krensky, C Clayberger KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8 Oncogene, 2016-04-04;0(0):. 2016-04-04 [PMID: 27041562] (Western Blot, Human)	Western Blot	Human
Shin J, Carr A, Corner G, Togel L, Davaos-Salas M, Tran H, Chueh A, Al-Obaidi S, Chionh F, Ahmed N, Buchanan D, Young J, Malo M, Hodin R, Arango D, Sieber O, Augenlicht L, Dhillon A, Weber T, Mariadason J The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner. J Biol Chem, 2014-07-18;289(36):25306-16. 2014-07-18 [PMID: 25037223] (ChIP, Human)	ChIP	Human
Biton M, Levin A, Slyper M, Alkalay I, Horwitz E, Mor H, Kredo-Russo S, Avnit-Sagi T, Cojocaru G, Zreik F, Bentwich Z, Poy MN, Artis D, Walker MD, Hornstein E, Pikarsky E, Ben-Neriah Y Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk. Nat. Immunol., 2011-01-30;12(3):239-46. 2011-01-30 [PMID: 21278735] (IHC-P, Western Blot, Mouse)	IHC-P, Western Blot	Mouse
Show All 17 Publications. Collapse Publications.

Array AF3758

• KLF5 Antibodies
• KLF5 ELISA Kits
• KLF5 Lysate
• KLF5 Proteins