KCNJ1 Antibody

FUNCTION: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.; Tissue specificity: In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.; Subcellular location: Membrane, Multi-pass membrane protein.; Involvement in disease: Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: ICC/IF, IF/IHC.

Showing Publications 1 - 4 of 4.

Publications using NBP1-82874	Applications	Species
Edwards A, Ralph DL, Mercado A, McDonough AA Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na+ and K American journal of physiology. Renal physiology 2023-10-12 [PMID: 37823196]
Kortenoeven MLA, Cheng L, Wu Q, Fenton RA An in vivo protein landscape of the mouse DCT during high dietary K+ or low dietary Na+ intake American journal of physiology. Renal physiology 2021-05-01 [PMID: 33779313] (ICC/IF, Mouse)	ICC/IF	Mouse
Zachar R, Al-Mashhadi A, Dimke H et al. Hydronephrosis is associated with elevated plasmin in urine in pediatric patients and rats and changes in NCC and g-ENaC abundance in rat kidney Am. J. Physiol. Renal Physiol. 2018-05-16 [PMID: 29767556] (IF/IHC, Rat)	IF/IHC	Rat
Vidal-Petiot E, Elvira-Matelot E, Mutig K et al. WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron. Proc Natl Acad Sci U S A 2013-08-27 [PMID: 23940364]

Array NBP1-82874

• KCNJ1 Antibodies
• KCNJ1 Lysate
• KCNJ1 Proteins