IGSF8/CD316 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IGSF8, also known as PGRL (PG Regulatory-Like Protein), KASP (KAI/CD82 Associated Protein) and EWI-2 (Glu-Trp-Ile motif 2), is a widely expressed transmembrane adhesion protein. It interacts with beta 1 Integrins and various tetraspanins including CD9, CD81 and CD82. IGSF8 contains four extracellular Ig-like domains. IGSF8 over-expression in transformed cells inhibits cell migration and suppresses cancer metastatic potential. Mouse and human IGSF8 share 90% amino acid sequence identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 6 applications: Flow Cytometry, ICC, IHC, IHC-Fr, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using AF3117	Applications	Species
Schmidt, SC;Massenberg, A;Homsi, Y;Sons, D;Lang, T; Microscopic clusters feature the composition of biochemical tetraspanin-assemblies and constitute building-blocks of tetraspanin enriched domains Scientific reports 2024-01-24 [PMID: 38267610] (ICC, Human)	ICC	Human
Wang J, Rattner A, Nathans J Bacterial meningitis in the early postnatal mouse studied at single-cell resolution eLife 6/15/2023 [PMID: 37318981]
MP LaPierre, K Lawler, S Godbersen, IS Farooqi, M Stoffel MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis Nature Communications, 2022-09-29;13(1):5733. 2022-09-29 [PMID: 36175420] (Western Blot, Mouse)	Western Blot	Mouse
N Reppert, T Lang A conserved sequence in the small intracellular loop of tetraspanins forms an M-shaped inter-helix turn Scientific Reports, 2022-03-16;12(1):4494. 2022-03-16 [PMID: 35296690] (Western Blot, Human)	Western Blot	Human
Lisa L Kirkemo, Susanna K Elledge, Jiuling Yang, James R Byrnes, Jeff E Glasgow, Robert Blelloch et al. Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells eLife 3/8/2022 [PMID: 35257663]
MD Johnson, MF Otuki, DA Cabrini, R Rudolph, DA Witherden, WL Havran Hspa8 and ICAM-1 as damage-induced mediators of &gamma&delta T cell activation Journal of leukocyte biology, 2021-04-13;0(0):. 2021-04-13 [PMID: 33847413] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Chenying Fu, Qing Zhang, Ani Wang, Songpeng Yang, Yangfu Jiang, Lin Bai et al. EWI‐2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis Molecular Oncology 2021-05-01 [PMID: 33605506]
N Apóstolo, SN Smukowski, J Vanderlind, G Condomitti, V Rybakin, J Ten Bos, L Trobiani, S Portegies, KM Vennekens, NV Gounko, D Comoletti, KD Wierda, JN Savas, J de Wit Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer Nat Commun, 2020-10-14;11(1):5171. 2020-10-14 [PMID: 33057002] (ICC, IHC, Mouse, Rat)	ICC, IHC	Mouse, Rat
Bye C, Jonsson M, Bjorklund A, Parish C, Thompson L Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors. Proc Natl Acad Sci U S A, 2015-03-09;112(15):E1946-55. 2015-03-09 [PMID: 25775569] (Flow Cytometry, IHC, Mouse, Rat)	Flow Cytometry, IHC	Mouse, Rat
Wang H, Sharma C, Knoblich K, Granter S, Hemler M EWI-2 negatively regulates TGF-beta signaling leading to altered melanoma growth and metastasis. Cell Res, 2015-02-06;25(3):370-85. 2015-02-06 [PMID: 25656846] (IHC, Mouse)	IHC	Mouse
Ray A, Treloar H IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses. Mol Cell Neurosci, 2012-06-09;50(3):238-49. 2012-06-09 [PMID: 22687584] (IHC-Fr, Immunoprecipitation, Western Blot, Mouse)	IHC-Fr, Immunoprecipitation, Western Blot	Mouse
Show All 11 Publications. Collapse Publications.

Array AF3117

• IGSF8/CD316 Antibodies
• IGSF8/CD316 Proteins
• IGSF8/CD316 Proteins and Enzyme