TACI/TNFRSF13B/CVID Antibody

Simultaneously four different laboratories identified a a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 (1), THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase (2), BAFF (for B cell activating factor belonging to the TNF family) (3) and BlyS (B lymphocyte stimulator) (4). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The receptor for BlyS/BAFF appears to be expressed predominantly on B cells and activated T cells (5). Recently two orphan receptors TACI (6) and BCMA (,8) have been shown to be receptors for BlyS/BAFF (6-9). TACI is expressed on B cells and signals through CAML, activating the transcription factors NF-AT, NF-kB, and AP-1. TACI is a type III transmembrane protein, as defined by the lack of a cleaved signal sequence and its N-terminal extracellular exposure. The cDNA codes for 293 amino acids with predicted molecular weight of approx. 32 kDa.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, IHC-P.

Showing Publications 1 - 7 of 7.

Publications using NB100-56516	Applications	Species
Ohmatsu H, Sugaya M, Miyagaki T et al. BAFF levels are increased in lesional skin and sera in patients with cutaneous T-cell lymphoma. Br J Dermatol. 2012-08-01 [PMID: 22512719] (IHC-P, Human) Details: TACl (IMG-249). 1. IHC(paraffin): Human cutaneous T-cell lymphoma skin lesions, Fig 2.	IHC-P	Human
Marcel V, Petit I, Murray-Zmijewski F et al. Diverse p63 and p73 isoforms regulate Delta133p53 expression through modulation of the internal TP53 promoter activity. Cell Death Differ. 2012-05-01 [PMID: 22075982] (Human)		Human
Zaher M, Tang R, Bombarda I et al. Hyperforin induces apoptosis of chronic lymphocytic leukemia cells through upregulation of the BH3-only protein Noxa. Int J Oncol. 2012-01-01 [PMID: 21947285]
Zaher Murhaf, Mirshahi Massoud, Nuraliev Yusuf et al. The BH3-only protein Noxa is stimulated during apoptosis of chronic lymphocytic leukemia cells triggered by M2YN, a new plant-derived extract. Int J Oncol. 2011-10-01 [PMID: 21750864]
Pelekanou Vassiliki, Notas George, Theodoropoulou Katerina et al. Detection of the TNFSF members BAFF, APRIL, TWEAK and their receptors in normal kidney and renal cell carcinomas. Anal Cell Pathol (Amst). 2011-01-01 [PMID: 21483105] (IF/IHC, Human)	IF/IHC	Human
Alexaki VI, Notas G, Pelekanou V et al. Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol. 2009-11-01 [PMID: 19828625] (IHC-P, Human) Details: TACI (IMG-249) IHC (paraffin): Human epithelial, breast, and renal peritumoral fat, Fig fat 1 & 2.	IHC-P	Human
Pelekanou Vassiliki, Kampa Marilena, Kafousi Maria et al. Expression of TNF-superfamily members BAFF and APRIL in breast cancer: immunohistochemical study in 52 invasive ductal breast carcinomas. BMC Cancer. 2008-01-01 [PMID: 18366696] (IF/IHC, Human)	IF/IHC	Human

Array NB100-56516

• TACI/TNFRSF13B/CVID Antibodies
• TACI/TNFRSF13B/CVID ELISA Kit
• TACI/TNFRSF13B/CVID Lysate
• TACI/TNFRSF13B/CVID Proteins
• TACI/TNFRSF13B/CVID ELISAs
• TACI/TNFRSF13B/CVID Proteins and Enzymes