Ifi204 Antibody

Interferon-activable protein 204 belongs to the HIN-200 family, which contains one DAPIN domain and two HIN-200 domains. It is reported to inhibit transcription of ribosomal RNA and thus acts as a multifunctional regulator of cell proliferation and differentiation. It is reported to act as a transcriptional coactivator of Cbfa1 (Core binding factor alpha-1) and enhances osteoblast differentiation. It enables skeletal muscle and cardiac myocyte differentiation by sequestering Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation. It is also reported that Ifi204 is trancriptionally activated in response to M-CSF and thus involved in macrophage differentiation in myeloid progenitor cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: KO, WB.

Showing Publications 1 - 7 of 7.

Publications using NBP2-27153	Applications	Species
Lim GY, Cho SW, Ka NL et al. IFI16/Ifi202 released from breast cancer induces secretion of inflammatory cytokines from macrophages and promotes tumor growth Journal of cellular physiology 2023-04-16 [PMID: 37062941] (WB, KO)	WB, KO
Wang J, Qin X, Huang Y et al. Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells Journal of virology 2023-02-28 [PMID: 36749073]
Anh Cuong Hoang, László Sasi-Szabó, Tibor Pál, Tamás Szabó, Victoria Diedrich, Annika Herwig, Kathrin Landgraf, Antje Körner, Tamás Röszer Mitochondrial RNA stimulates beige adipocyte development in young mice Nature Metabolism 2022-11-28 [PMID: 36443525]
Ka NL, Lim GY, Kim SS et al. Type I IFN stimulates IFI16-mediated aromatase expression in adipocytes that promotes E2-dependent growth of ER-positive breast cancer Cellular and molecular life sciences : CMLS 2022-05-20 [PMID: 35593921] (WB, Mouse) Details: Fig. 3	WB	Mouse
Gray EE, Winship D, Snyder JM et al. The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA. Immunity. 2016-08-16 [PMID: 27496731] (WB, Mouse)	WB	Mouse
Hoang A, Yu H, Lin Y Et al. Immune privilege of adipocyte mitochondria protects from obesity Research Square 2021-11-04
Ka NL, Lim GY, Hwang S et al. IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer Cell reports 2021-12-21 [PMID: 34936865] (WB)	WB

Array NBP2-27153

• Ifi204 Antibodies