IFI202b Antibody

Interferon-activable protein 202 (Ifi202b, p202) belongs to the HIN-200 family and contains two HIN-200 domains. It is reported to inhibit transcriptional activity of several transcription factors, including NF-kappaB p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. It has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. It is an interferon-inducible protein which is responsible for Lupus susceptibility and is induced by Interleukin-6.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NBP2-27066	Applications	Species
Panchanathan R, Liu H, Leung YK et al. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells. Mol. Cell. Endocrinol. 2015-08-12 [PMID: 26277401] (WB, Mouse) Details: IFI202b antibody (Imgenex: IMG-6670A) was used for WB on lysates of purified CD11b+ murine bone marrow-derived cells / BMCs (from C57BL/6 female mice) that were treated or not with 10 nM of Bisphenol A/ for 14 h in vitro (Fig. 3B). WB was also performed on lysates of murine macrophages cell line J774.A1 treated or not with 10 or 100 nM of BPA. WB was also performed under similar treatment conditions on lysates of BMCs which were isolated from non lupus-prone C57BL/6 or age-matched lupus-prone [(NZB × NZW)F1] female mice (Fig 5).	WB	Mouse
Panchanathan R, Liu H, Xin D, Choubey D. Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING. Innate Immun. [PMID: 24131791] (WB, Mouse, Human)	WB	Mouse, Human
Panchanathan R, Liu H, Liu H et al. Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis. J Immunol. 2012-01-01 [PMID: 22116829] (WB) Details: WB (mouse splenocytes or RAW 264.7 cells), Figs 1A, 2F, 3B, 3D, 6B, 6E, 7A. The specificity of the antibody was validated with recombinantly expressed mouse p202 protein by WB (see publication for details).	WB

Array NBP2-27066

• IFI202b Antibody
• IFI202b Protein