IDH2 Antibody (5F11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 7 of 7.

Publications using H00003418-M01	Applications	Species
Jitka S, Klara G, Ale? D et al. Biochemical Background in Mitochondria Affects 2HG Production by IDH2 and ADHFE1 in Breast Carcinoma. Cancers (Basel). 2021-04-04 [PMID: 33916579]
Katarina S, Jitka S, Klara G et al. SIRT3 and GCN5L Regulation of NADP+- And NADPH-driven Reactions of Mitochondrial Isocitrate Dehydrogenase IDH2. Sci Rep. 2020-05-26 [PMID: 32457458]
Ferreira JCB, Campos JC, Qvit N et al. A selective inhibitor of mitofusin 1-beta IIPKC association improves heart failure outcome in rats. Nat Commun. 2019-04-09 [PMID: 30659190]
Gambichler T, Mamali K, Patsinakidis N et al. Decreased expression of ten-eleven translocation 2 protein is associated with progressive disease and death in patients with mucosis fungoides. Br J Dermatol. 2015-09-19 [PMID: 26384468]
Gambichler T, Terras S, Kreuter A, Skrygan M. Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus - further support for epigenetic mechanisms. Br J Dermatol. 2013-10-27 [PMID: 24164308]
Rettberg JR, Hamilton RT, Mao Z et al. The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Brain Res. [PMID: 21238431]
Halbert D, Domenyuk V, Spetzler D et al. Aptamers and uses thereof United States Patent Application US 9958448 B2 2018-01-01

Array H00003418-M01

• IDH2 Antibodies
• IDH2 ELISA Kits
• IDH2 Lysate
• IDH2 Protein