SDHB Antibody

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using NBP1-87069	Applications	Species
Kang K, Ko J, Lee H et al. Surgically Metabolic Resection of Pericardial Fat to Ameliorate Myocardial Mitochondrial Dysfunction in the Acute Myocardial Infarction Obese Rat Journal of Korean Medical Science 2022-02-08 [PMID: 35257523] (WB, Rat)	WB	Rat
Thomas G Papathomas, Lindsey Oudijk, Alexandre Persu et al. SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T). Modern Pathology 2015-02-27 [PMID: 25720320] (IF/IHC, Human)	IF/IHC	Human
Desmurs M, Foti M, Raemy E et al. C11orf83, a Mitochondrial Cardiolipin-Binding Protein Involved in bc1 Complex Assembly and Supercomplex Stabilization. Mol Cell Biol 2015-04-01 [PMID: 25605331] (WB, Human)	WB	Human
Bayley JP, Oldenburg RA, Nuk J et al. Paraganglioma and pheochromocytoma upon maternal transmission of SDHD mutations. BMC Med Genet 2014-10-10 [PMID: 25300370] (IF/IHC, Human)	IF/IHC	Human
Nannini M, Astolfi A, Urbini M et al. Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST). BMC Cancer 2014-09-20 [PMID: 25239601] (IF/IHC, Human)	IF/IHC	Human
Clarissa A Cassol, Daniel Winer, Wei Liu et al. Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomas. Modern Pathology 2014-01-01 [PMID: 24390213] (IF/IHC, Human)	IF/IHC	Human
Jamilloux Y, Favier J, Pertuit M et al. A MEN1 syndrome with a paraganglioma. Eur J Hum Genet 2014-02-01 [PMID: 23778871] (IF/IHC, Human)	IF/IHC	Human
Pantaleo MA, Astolfi A, Urbini M et al. Analysis of all subunits, SDHA, SDHB, SDHC, SDHD, of the succinate dehydrogenase complex in KIT/PDGFRA wild-type GIST. Eur J Hum Genet 2014-01-01 [PMID: 23612575] (IF/IHC)	IF/IHC
Rapizzi E, Ercolino T, Canu L et al. Mitochondrial function and content in pheochromocytoma/paraganglioma of succinate dehydrogenase mutation carriers. Endocr Relat Cancer 2012-05-01 [PMID: 22323561]
Xekouki P, Pacak K, Almeida M et al. Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH?. J Clin Endocrinol Metab 2012-03-01 [PMID: 22170724]
Marchiani S, Tamburrino L, Giuliano L et al. Sumo1-ylation of human spermatozoa and its relationship with semen quality. Int J Androl 2011-12-01 [PMID: 21039605]
Gaal J, Stratakis CA, Carney JA et al. SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors. Mod Pathol 2011-01-01 [PMID: 20890271]
Alataki D, Triantafyllidis A, Gaal J et al. A non-catecholamine-producing sympathetic paraganglioma of the spermatic cord: the importance of performing candidate gene mutation analysis. Virchows Arch 2010-11-01 [PMID: 20842377]
Burnichon N, Briere JJ, Libe R et al. SDHA is a tumor suppressor gene causing paraganglioma. Hum Mol Genet 2010-08-01 [PMID: 20484225]
Favier J, Briere JJ, Burnichon N et al. The Warburg effect is genetically determined in inherited pheochromocytomas. PLoS One 2009-09-01 [PMID: 19763184]
van Nederveen FH, Gaal J, Favier J et al. An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. Lancet Oncol 2009-08-01 [PMID: 19576851]
Show All 16 Publications. Collapse Publications.

Array NBP1-87069

• SDHB Antibodies
• SDHB Lysate
• SDHB Proteins