Human TGF-beta RII DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 3 of 3.

Publications using DY241	Applications	Species
X Hu, M Binter, K Hufendiek, J Tode, C Framme, H Fuchs MiR-302d inhibits TGFB-induced EMT and promotes MET in primary human RPE cells PLoS ONE, 2022-11-28;17(11):e0278158. 2022-11-28 [PMID: 36441751] (Human)		Human
NB Nataraj, A Noronha, JS Lee, S Ghosh, HR Mohan Raju, A Sekar, B Zuckerman, M Lindzen, E Tarcitano, S Srivastava, M Selitrenni, I Livneh, D Drago-Garc, O Rueda, C Caldas, S Lev, T Geiger, A Ciechanove, I Ulitsky, R Seger, E Ruppin, Y Yarden Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors Cell Reports, 2022-02-22;38(8):110418. 2022-02-22 [PMID: 35196484] (Human)		Human
dos Santos G, Rogel M, Baker M, Troken J, Urich D, Morales-Nebreda L, Sennello J, Kutuzov M, Sitikov A, Davis J, Lam A, Cheresh P, Kamp D, Shumaker D, Budinger G, Ridge K Vimentin regulates activation of the NLRP3 inflammasome. Nat Commun, 2015-03-12;6(0):6574. 2015-03-12 [PMID: 25762200] (Mouse)		Mouse

Array DY241

• TGF-beta RII Antibodies
• TGF-beta RII ELISA Kit
• TGF-beta RII Lysate
• TGF-beta RII Proteins and Enzymes
• TGF-beta RII ELISA