HMG-CoA Reductase/HMGCR Antibody (JF0981)

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: Simple Western, WB.

Showing Publications 1 - 7 of 7.

Publications using NBP2-66888	Applications	Species
Dolcen DN The Role of Nicotinamide N-Methyltransferase in Triple-Negative Breast Cancer Gene Expression and in vivo Metastatic Potential Thesis 2022-01-01 (WB, Human)	WB	Human
Matthew Grove, Hyukmin Kim, Shuhuan Pang, Jose Paz Amaya, Guoqing Hu, Jiliang Zhou, Michel Lemay, Young-Jin Son, Klaus-Armin Nave, Timothy E Behrens TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves eLife 2024-03-08 [PMID: 38456457]
Thapa K, Kadiri JJ, Saukkonen K et al. Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver eLife 2023-07-25 [PMID: 37490042]
Y Wang, J Wang, X Li, X Xiong, J Wang, Z Zhou, X Zhu, Y Gu, D Dominissin, L He, Y Tian, C Yi, Z Fan N1-methyladenosine�methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism Nature Communications, 2021-11-02;12(1):6314. 2021-11-02 [PMID: 34728628]
Dalton GD, Oh SH, Tang L et al. Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice iScience 2021-09-24 [PMID: 34568800] (WB, Mouse)	WB	Mouse
Kohlhaas J, Jager M. A, et al. Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Exp Cell Res 2021-01-07 [PMID: 33422461] (Simple Western, Human)	Simple Western	Human
Bharadwaj S, Devi S, Sarma P et al. Prophylactic role of Premna herbacea, a dietary leafy vegetable in managing hepatic steatosis via regulating AMPK/SREBP1/ACC/HMGCR signaling pathway Food Bioscience

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	Simple Western	Human	07/03/2018	View Summary Application Simple Western Sample Tested SVG-A whole cell lysate Species Human Lot HJ1226

Array NBP2-66888

• HMG-CoA Reductase/HMGCR Antibodies
• HMG-CoA Reductase/HMGCR Lysate
• HMG-CoA Reductase/HMGCR Protein
• HMG-CoA Reductase/HMGCR Proteins and Enzyme