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HES6 Antibody

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Immunocytochemistry/ Immunofluorescence: HES6 Antibody [NBP3-17721] - Staining of human cell line SK-MEL-30 shows localization to nuclear bodies.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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HES6 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: PIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HES6
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
Application Notes
Immunocytochemistry/Immunofluorescence, PFA/Triton X-100 is recommended for fixation/permeabilization.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.2, 40% glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for HES6 Antibody

  • BHLHB41
  • bHLHb41Class B basic helix-loop-helix protein 41
  • bHLHc23
  • C-HAIRY1
  • hairy and enhancer of split 6 (Drosophila)
  • Hairy and enhancer of split 6
  • HES-6
  • transcription cofactor HES-6

Background

HES6 is a transcription cofactor that itself does not bind to DNA but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription in its presence. HES6 appears to have novel functions in tumor and cancer cell lines, although these have not yet been elucidated fully.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for HES6 Antibody (NBP3-17721) (0)

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

FAQs for HES6 Antibody (NBP3-17721) (0)

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Secondary Antibodies

 

Isotype Controls

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Blogs on HES6.

Using the Hif-1 Alpha Antibody in Prostate Cancer Research
The Hypoxia-inducible Factor 1 (HIF1) protein is a heterodimeric transcription factor which plays an important role in mammalian oxygen homeostasis in conditions of hypoxia, or low oxygen concentration. HIF-1 alpha antibody reagents are widely used in...  Read full blog post.

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Bioinformatics

Gene Symbol HES6