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HES6 Antibody (OTI1D6) [Janelia Fluor® 635]

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-72008JF635
    • Availability
      Product Discontinued

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HES6 Antibody (OTI1D6) [Janelia Fluor® 635] Summary

Immunogen
Full length human recombinant protein of human HES6 (NP_061115) produced in E.coli.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
HES6
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for HES6 Antibody (OTI1D6) [Janelia Fluor® 635]

  • BHLHB41
  • bHLHb41Class B basic helix-loop-helix protein 41
  • bHLHc23
  • C-HAIRY1
  • hairy and enhancer of split 6 (Drosophila)
  • Hairy and enhancer of split 6
  • HES-6
  • transcription cofactor HES-6

Background

HES6 is a transcription cofactor that itself does not bind to DNA but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription in its presence. HES6 appears to have novel functions in tumor and cancer cell lines, although these have not yet been elucidated fully.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Additional HES6 Products

Array NBP2-72008JF635

Research Areas for HES6 Antibody (NBP2-72008JF635)

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Blogs on HES6.

Using the Hif-1 Alpha Antibody in Prostate Cancer Research
The Hypoxia-inducible Factor 1 (HIF1) protein is a heterodimeric transcription factor which plays an important role in mammalian oxygen homeostasis in conditions of hypoxia, or low oxygen concentration. HIF-1 alpha antibody reagents are widely used in...  Read full blog post.

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Bioinformatics

Gene Symbol HES6