H4/n [ac Lys16] Antibody Summary
Immunogen |
A synthetic acetylated peptide around K16 of human H4/n (NP_003539.1).
Sequence: GAKRH |
Modification |
ac Lys16 |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
HIST2H4A |
Purity |
Affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- ELISA
- Western Blot 1:500 - 1:1000
|
Theoretical MW |
11 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
Storage |
Store at -20C. Avoid freeze-thaw cycles. |
Buffer |
PBS (pH 7.3), 50% glycerol |
Preservative |
0.01% Thimerosal |
Purity |
Affinity purified |
Alternate Names for H4/n [ac Lys16] Antibody
Background
Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber as they play a critical role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. H4/N is a103 amino acid long, 11 kDA protein encoded by the HIST2H4A gene found on chromosome 1. HIST2H4A is one of four histone genes in this specific cluster that are duplicated, representing the centromeric copy. HIST2H4A is involved in type II interferon signaling, development notch signaling pathway, transcription Sin3 and NuRD in transcription regulation, and telomere maintenance through interactions with genes HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, and HIST1H3F. It has been investigated for its role in lymphoma, carcinoma, leukemia, herpes simplex, thyroiditis, and lupus.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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