GRP78/HSPA5 Antibody

GRP78, a 78 kDa glucose-regulated protein, also known as BiP or immunoglobulin heavy chain binding protein, is a stress-response protein which is induced by agents or conditions that adversely affect endoplasmic reticulum (ER) function. This protein is essential for the proper glycosylation, folding and assembly of many membrane bound and secreted proteins. GRP78 is critical for maintenance of cell homeostasis and the prevention of apoptosis. GRP78 protein levels have been shown to be a reliable biomarker of hypoglycermia as well as serving a neuroprotective function in neurons exposed to glutamate and oxidative stress. GRP78 levels are reduced in the brains of Alzheimer's Disease patients and decreased expression of GRP78 is found associated with missense mutations in the human presenilin-1 (PS1) gene. The induction of the GRP78 protein has been associated with the development of drug-resistance to antitumor drugs.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-56411	Applications	Species
Li T, Yang Y, Li Y et al. Platelets mediate inflammatory monocyte activation by SARS-CoV-2 Spike protein The Journal of clinical investigation 2021-12-29 [PMID: 34964720] (WB, Human)	WB	Human
Egawa N, Yamamoto K, Inoue H et al. The endoplasmic reticulum stress sensor, ATF6a, protects against neurotoxin-induced dopaminergic neuronal death. J Biol Chem. 2011-03-11 [PMID: 21131360] (WB, ICC/IF, Mouse) Details: BiP/GRP78 (IMG-5228A). WB & IF/ICC: Mouse midbrain or striatum from ATF6 alpha WT +/+ or ATF6 alpha kO -/- mice, Fig 2B.	WB, ICC/IF	Mouse
Panaretakis Theocharis, Kepp Oliver, Brockmeier Ulf et al. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J. 2009-03-04 [PMID: 19165151] (Human)		Human
Sharma A, Masri J, Jo OD et al. Protein kinase C regulates internal initiation of translation of the GATA-4 mRNA following vasopressin-induced hypertrophy of cardiac myocytes. J Biol Chem. 2007-03-30 [PMID: 17284439] (WB) Details: BiP/GRP78 (IMG-5228A). WB: H9c2 ventricular cardiomyocytes treated with arginine vasopressin (AVP), Fig 8A.	WB

Array NB100-56411

• GRP78/HSPA5 Antibodies
• GRP78/HSPA5 ELISA Kits
• GRP78/HSPA5 Lysate
• GRP78/HSPA5 Proteins