Caspase-12 Antibody - BSA Free

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Chicken.

We have publications tested in 3 applications: B/N, ICC/IF, WB.

Showing Publications 1 - 6 of 6.

Publications using NBP1-76801	Applications	Species
Chen J, Zhou Y, Zhu E et al. Mycoplasma ovipneumoniae induces caspase-8-dependent extrinsic apoptosis and p53- and ROS-dependent intrinsic apoptosis in murine alveolar macrophages Virulence 2021-12-31 [PMID: 34678131] (B/N)	B/N
Wang H, Dou S, Zhu J et al. Ghrelin protects dopaminergic neurons against MPTP neurotoxicity through promoting autophagy and inhibiting endoplasmic reticulum mediated apoptosis Brain Res 2020-07-26 [PMID: 32710901] (WB, ICC/IF)	WB, ICC/IF
Yao J, Ma Y, Lin X et al. The Attenuating Effect of the Intraovarian Bone Morphogenetic Protein 4 on Age-Related Endoplasmic Reticulum Stress in Chicken Follicular Cells Oxid Med Cell Longev 2020-06-08 [PMID: 32587659] (WB, Chicken)	WB	Chicken
Jang Y, Kwon I, Song W et al. Modulation of mitochondrial phenotypes by endurance exercise contributes to neuroprotection against a MPTP-induced animal model of PD Life Sci. 2018-08-22 [PMID: 30144449] (WB, Mouse)	WB	Mouse
Nakagawa T, Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J Cell Biol. 2000-08-21 [PMID: 10953012]
Du K, Zheng X, Lv J et al. Cordycepin exacerbates cadmium-induced neurotoxicity via promoting endoplasmic reticulum stress-associated apoptosis Journal of Functional Foods 2022-02-01 (WB, Mouse)	WB	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: YONGCHUL JANG	WB	Mouse	05/03/2017	View Summary Application Western Blot Sample Tested Mouse brain Species Mouse
Enlarge	4 reviewed by: YONGCHUL JANG	WB	Mouse	03/16/2017	View Summary Application Western Blot Sample Tested Mouse brain Species Mouse Lot 2327-1104

Array NBP1-76801

• Caspase-12 Antibodies
• Caspase-12 ELISA Kit
• Caspase-12 Proteins