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Growth Hormone R Antibody (10C11)

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Immunohistochemistry: Growth Hormone R Antibody (10C11) [NBP3-26554] - Image of Growth Hormone R Antibody (10C11) diluted at 1:100 and staining in paraffin-embedded human liver tissue performed. After dewaxing and ...read more
Immunohistochemistry: Growth Hormone R Antibody (10C11) [NBP3-26554] - Image of Growth Hormone R Antibody (10C11) diluted at 1:100 and staining in paraffin-embedded human liver tissue performed. After dewaxing and ...read more
Immunocytochemistry/ Immunofluorescence: Growth Hormone R Antibody (10C11) [NBP3-26554] - Staining of HepG2 Cells with Growth Hormone R Antibody (10C11) at 1:50, counter-stained with DAPI. The cells were fixed in 4% ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, ICC/IF, IHC
Clone
10C11
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Growth Hormone R Antibody (10C11) Summary

Additional Information
Recombinant monoclonal antibody expressed in HEK293F cells
Immunogen
A synthesized peptide derived from Human Growth Hormone R [UniProt P10912]
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
GHR
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence 1:20-1:200
  • Immunohistochemistry 1:50-1:200

Packaging, Storage & Formulations

Storage
Store at -20 to -70C. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.4, 150mM NaCl and 50% glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for Growth Hormone R Antibody (10C11)

  • GH receptor
  • GHBP
  • GHR
  • growth hormone binding protein
  • Growth Hormone R
  • growth hormone receptor
  • serum binding protein
  • Somatotropin receptor

Background

Growth hormone receptor encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GHR