Prolactin R Antibody (U5)

Prolactin (PRL) is a hormone involved in a variety of important functions including ion transport and osmoregulation, stimulation of milk, protein synthesis as well as the regulation of numerous reproductive functions. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor, a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. The PRL receptor consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Rat, Bovine.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using NB300-561	Applications	Species
Wang B, Shi L, Men J et al. Controlled synchronization of prolactin/STAT5 and AKT1/mTOR in bovine mammary epithelial cells In Vitro Cell. Dev. Biol. Anim. 2020-02-20 [PMID: 32078727] (Human)		Human
Wang B, Men J, Wang C et al. Laminin-dependent integrin beta 1 signaling regulates milk protein synthesis via prolactin/STAT5 pathway in bovine mammary epithelial cells Biochem. Biophys. Res. Commun. 2020-01-24 [PMID: 31987497] (WB, Bovine)	WB	Bovine
Ochoa-Amaya JE, Queiroz-Hazarbassanov N, Namazu LB et al. Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs Neuroimmunomodulation 2018 Jun 06 [PMID: 29874677] (ICC/IF, Rat) Neuroimmunomodulation. [PMID: 29874677] (ICC/IF, Rat)	ICC/IF	Rat
Perrot-Applanat M, Gualillo O, Buteau H, Edery M, Kelly PA. Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation. J. Cell Sci., 110: 1123-1132. 1997-01-01 [PMID: 9175708]
Gagnerault MC, Touraine P, Savino W, Kelly PA, Dardenne M. Expression of prolactin receptors in murine lymphoid cells in normal and autoimmune situations. J Immunol. 1993 Jun 15;150(12):5673-81. 1993-01-01 [PMID: 8515082]
Dardenne M, de Moraes Mdo C, Kelly PA, Gagnerault MC. Prolactin receptor expression in human hematopoietic tissues analyzed by flow cytofluorometry. Endo., 134(5): 2108-2114. 1994-01-01 [PMID: 8156910]
Rui H, Lebrun JJ, Kirken RA, Kelly PA, Farrar WL. JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization. Endo., 135(4): 1299-1306. 1994-01-01 [PMID: 7925093]
Sorenson RL, Stout LE. Prolactin receptors and JAK2 in islets of Langerhans: an immunohistochemical analysis. Endo., 136(9): 4092-4098. 1995-01-01 [PMID: 7649117]
Royster M, Driscoll P, Kelly PA, Freemark M. The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation. Endo, 136(9): 3892-3900. 1995-01-01 [PMID: 7649097]
Katoh M, Raguet S, Zachwieja J, Djiane J, Kelly PA. Hepatic prolactin receptors in the rat: characterization using monoclonal antireceptor antibodies. Endo, 120: 739-749. 1987-01-01 [PMID: 3803302]
Okamura H, Zachwieja J, Raguet S, Kelly PA. Characterization and applications of monoclonal antibodies to the prolactin receptor. Endo., 124(5): 2499-2508. 1989-01-01 [PMID: 2707162]
Dardenne M, Kelly PA, Bach JF, Savino W. Identification and functional activity of prolactin receptors in thymic epithelial cells. Proc. Natl. Acad. Sci., USA, 88: 9700-9704. 1991-01-01 [PMID: 1946390]
Rozakis-Adcock M, Kelly PA. Mutational analysis of the ligand-binding domain of the prolactin receptor. J. Biol. Chem., 266(25): 16472-16477. 1991-01-01 [PMID: 1885580]
Show All 13 Publications. Collapse Publications.

Array NB300-561

• Prolactin R Antibodies
• Prolactin R Antibody Pair
• Prolactin R ELISA Kit
• Prolactin R Lysate
• Prolactin R Proteins and Enzymes