eIF2 alpha/EIF2S1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

elF2 alpha (eukaryotic translation initiation factor 2 alpha subunit) is a subunit of the elF2 protein, an important regulator of translation initiation. Phosphorylation of elF2 alpha on Ser 52 increases the affinity of elF2 alpha for elF2B, a guanine nucleotide exchange factor needed for the recycling of elF2-GDP to elF2-GTP. Reduction of elF2-GTP levels leads to the suppression of the overall rate of protein synthesis. Heme-regulated inhibitor (HRI), ER-resident protein kinase PERK, dsRNA activated protein kinase PKR, and the homologue of the S. cerevisiae protein kinase GCN2 are all elF2 alpha kinases.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 3 of 3.

Publications using AF3997	Applications	Species
Benjamin L. Zaepfel, Jeffrey D. Rothstein Polyadenylated RNA and RNA-Binding Proteins Exhibit Unique Response to Hyperosmotic Stress Frontiers in Cell and Developmental Biology 12/14/2021 [PMID: 34970554]
L Henss, T Scholz, A Grünweller, BS Schnierle Silvestrol Inhibits Chikungunya Virus Replication Viruses, 2018-10-30;10(11):. 2018-10-30 [PMID: 30380742] (Western Blot, Human)	Western Blot	Human
PM Tiwari, D Vanover, KE Lindsay, SS Bawage, JL Kirschman, S Bhosle, AW Lifland, C Zurla, PJ Santangelo Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection Nat Commun, 2018-10-01;9(1):3999. 2018-10-01 [PMID: 30275522] (Western Blot, Mouse)	Western Blot	Mouse

Array AF3997

• eIF2 alpha/EIF2S1 Antibodies
• eIF2 alpha/EIF2S1 Lysate
• eIF2 alpha/EIF2S1 Proteins