DEC1 Antibody - BSA Free

The basic helix-loop-helix (bHLH) transcription factor DEC1 (differentially expressed in chondrocytes protein 1) is wildly expressed in most normal tissues in a proportion of cells, whereas in tumors, its expression gets upregulated (potentially by hypoxia) in several malignancies such as breast, stomach, colon, lung, liver cancer and pancreatic ductal adenocarcinoma. The gene expression of DEC1 is regulated by various extracellular stimuli in a cell type-specific manner. Localized in the nucleus, it can homodimerize or heterodimerize with TCF3/E47, and interacts with ubiquitin-conjugating enzyme UBE2I/UBC9. DEC1 has emerged as one of the major circadian molecules alongwith its involvement in homeostasis of metabolism and energy. DEC1 has been shown to play a key role in various biological phenomena such as circadian rhythms, neurogenesis, neuroregulation, chondrogenesis, cellular growth, carcinogenesis, immune response balance as well as cellular senescence.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 10 applications: ChIP, Chemotaxis, Chip Cytometry, Flow Cytometry, IF/IHC, IHC, IHC-P, Simple Western, WB, Western Blot.

Showing Publications 1 - 10 of 43. Show All 43 Publications. Collapse Publications.

Publications using NB100-1800	Applications	Species
Chen Z, Javed N, Moore M et al. Integrative dissection of gene regulatory elements at base resolution Cell genomics 2023-06-14 [PMID: 37388913] (ChIP, Human)	ChIP	Human
Lv J, Wei Y, Yin JH et al. The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment Nature medicine 2023-06-01 [PMID: 37280275]
Pathmanapan, S;Poon, R;De Renshaw, TB;Nadesan, P;Nakagawa, M;Seesankar, GA;Ho Loe, AK;Zhang, HH;Guinovart, JJ;Duran, J;Newgard, CB;Wunder, JS;Alman, BA; Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation Cell reports 2023-06-01 [PMID: 37267108] (IHC, Human, Mouse)	IHC	Human, Mouse
Centeno PP, Pavet V, Marais R The journey from melanocytes to melanoma Nature reviews. Cancer 2023-06-01 [PMID: 37095242]
Nechanitzky R, Nechanitzky D, Ramachandran P et al. Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis Cell death and differentiation 2022-12-17 [PMID: 36528755] (ChIP, Mouse)	ChIP	Mouse
Hu X, Zou M, Ni L et al. Dec1 Deficiency Ameliorates Pulmonary Fibrosis Through the PI3K/AKT/GSK-3beta/beta-Catenin Integrated Signaling Pathway Frontiers in pharmacology 2022-03-09 [PMID: 35355710] (WB, Mouse, Human)	WB	Mouse, Human
Al-chalabi SA Long Noncoding RNA AK001796 as a Mediator of Epithelial-to-Mesenchymal Transition in Metastatic Breast Cancer Thesis 1905-07-13
Shearn, CT;Anderson, AL;Devereaux, MW;El Kasmi, KC;Orlicky, DJ;Sokol, RJ; Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition PloS one 2023-08-30 [PMID: 37647292] (Western Blot)	Western Blot
Montalvo AP, Gruskin ZL, Leduc A et al. An adult clock component links circadian rhythms to pancreatic ?-cell maturation bioRxiv 2023-08-17 [PMID: 37609178] (Flow Cytometry)	Flow Cytometry
Karakaya S, Gunnesson L, Elias E et al. Cytoplasmic HIF-2? as tissue biomarker to identify metastatic sympathetic paraganglioma Scientific reports 2023-07-18 [PMID: 37463949] (IHC-P, Human)	IHC-P	Human
Sui Y, Jiang H, Kellogg CM et al. Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7 Frontiers in oncology 2023-02-20 [PMID: 36890812] (WB)	WB
Nakamura S, Tanimoto K, Bhawal U Ribosomal Stress Couples with the Hypoxia Response in Dec1-Dependent Orthodontic Tooth Movement International Journal of Molecular Sciences 2022-12-29 [PMID: 36614058]
Sato F, Bhawal UK, Osaki S et al. Differential immunohistochemical expression of DEC1, CK 1 epsilon, and CD44 in oral atypical squamous epithelium and carcinoma in situ Molecular medicine reports 2022-05-01 [PMID: 35266015] (IF/IHC, Human)	IF/IHC	Human
Zhong Y, Walker SK, Pritykin Y et al. Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families Nature immunology 2022-01-01 [PMID: 34937932] (Mouse)		Mouse
Rauschmeier R, Reinhardt A, Gustafsson C et al. Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis The Journal of experimental medicine 2022-02-07 [PMID: 34919144]
Feng DD, Zheng B, Yu J et al. 17?-Estradiol Inhibits Proliferation and Oxidative Stress in Vascular Smooth Muscle Cells by Upregulating BHLHE40 Expression Frontiers in Cardiovascular Medicine 2021-11-30 [PMID: 34917665]
Uyeda Mj, Freeborn Ra, Cieniewicz B Et Al. BHLHE40 Regulates IL-10 and IFN-gamma Production in T Cells but Does Not Interfere With Human Type 1 Regulatory T Cell Differentiation Frontiers in immunology 2021-07-07 [PMID: 34305917] (WB, Simple Western)	WB, Simple Western
Sato F, Bhawal U, Sugiyama N et al. Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis. Clocks&Sleep 2020-01-03 [PMID: 33089188] (WB, IF/IHC, Human)	WB, IF/IHC	Human
Hu, G, Dong, X Et al. Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions. Nucleic Acids Res 2020-09-25 [PMID: 32885250] (IF/IHC, Mouse)	IF/IHC	Mouse
Partridge EC, Chhetri SB, Prokop JW et al. Occupancy maps of 208 chromatin-associated proteins in one human cell type Nature 2020-07-30 [PMID: 32728244]
Vignesh Sundararajan, Ming Tan, Tuan Zea Tan, Qing You Pang, Jieru Ye, Vin Yee Chung, Ruby Yun-Ju Huang SNAI1-Driven Sequential EMT Changes Attributed by Selective Chromatin Enrichment of RAD21 and GRHL2 Cancers 2020-05-02 [PMID: 32370157]
Pasula S, Tessneer KL, Fu Y, et al. Risk Variants with Opposing Functional Effects Result in Hypomorphic Expression of TNIP1 and Other Genes within a 3D Chromatin Network Arthritis & rheumatology (Hoboken, N.J.) 2019-12-05 [PMID: 31804013] (Chemotaxis, WB, Human)	Chemotaxis, WB	Human
Le HT, Sato F, Kohsaka A et al. Dec1 Deficiency Suppresses Cardiac Perivascular Fibrosis Induced by Transverse Aortic Constriction Int J Mol Sci 2019-10-08 [PMID: 31597354] (IF/IHC, Mouse)	IF/IHC	Mouse
Li C, Zhu B, Son YM et al. The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality Immunity [PMID: 31533057]
Rauschmeier R, Gustafsson C Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity. EMBO J 2019-01-10 [PMID: 31414712] (Chemotaxis, Mouse)	Chemotaxis	Mouse
Jarjour NN, Schwarzkopf EA, Bradstreet TR, Shchukina I et al. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity Nat. Immunol. 2019-06-01 [PMID: 31061528] (Chip Cytometry, Mouse)	Chip Cytometry	Mouse
Sato F, Otsuka T, Kohsaka A et al. Smad3 suppresses epithelial cell migration and proliferation via the clock gene Dec1, which negatively regulates the expression of clock genes Dec2 and Per1. Am. J. Pathol. 2019-01-18 [PMID: 30664860] (WB, Mouse)	WB	Mouse
Huynh JP, Lin CC, Kimmey JM et al. Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection J. Exp. Med. 2018-05-17 [PMID: 29773644] (WB, Mouse)	WB	Mouse
Hamilton KA, Wang Y, Raefsky SM et al. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus PLoS ONE 2018-05-01 [PMID: 29715265] (Chemotaxis, Mouse)	Chemotaxis	Mouse
Nakamura H, Bono H, Hiyama K, Kawamoto T. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions. PLoS ONE. 2018-02-21 [PMID: 29466367] (WB, Human)	WB	Human
Liu Q, Imaizumi T, Murakami K et al. DEC1 negatively regulates the expression of CXCL10 and CCL5 induced by poly IC in normal human mesangial cells Biomed. Res. 2017-08-10 [PMID: 28794402] (WB, Human)	WB	Human
Murakami K, Wu Y, Imaizumi T et al. DEC1 promotes hypoxia-induced epithelial-mesenchymal transition (EMT) in human hepatocellular carcinoma cells Biomed. Res. 2017-08-10 [PMID: 28794399] (WB, Human)	WB	Human
Sato F, Kohsaka A, Takahashi K et al. Smad3 and Bmal1 regulate p21 and S100A4 expression in myocardial stromal fibroblasts via TNF-alpha Histochem. Cell Biol. 2017-07-18 [PMID: 28721450] (WB, Mouse)	WB	Mouse
Sato Hidenobu, Wu Yunyan, Kato Yukio et al. DEC2 expression antagonizes cisplatin induced apoptosis in human esophageal squamous cell carcinoma. Molecular Medicine Reports 2017-05-11 [PMID: 28498447] (WB, Human)	WB	Human
Sato F, Muragaki Y, Kawamoto T et al. Rhythmic expression of DEC2 protein in vitro and in vivo. Biomed Rep 2016-06-01 [PMID: 27284410] (WB)	WB
Lin CC, Bradstreet TR, Schwarzkopf EA et al. IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 2016-02-08 [PMID: 26834156] (WB, Mouse)	WB	Mouse
Kim J, D'Annibale S, Magliozzi R et al. USP17- and SCFbTrCP-Regulated Degradation of DEC1 Controls the DNA Damage Response. Mol Cell Biol. 2014-09-08 [PMID: 25202122]
Ma W, Shi X, Lu S et al. Hypoxia-induced overexpression of DEC1 is regulated by HIF-1alpha in hepatocellular carcinoma. Oncol Rep. 2013-12-01 [PMID: 24100543]
Pawlikowski JS, McBryan T, van Tuyn J et al. Wnt signaling potentiates nevogenesis. Proc Natl Acad Sci U S A. 2013-10-01 [PMID: 24043806] (WB, Human)	WB	Human
Liu Y, Wang L, Lin XY et al. The transcription factor DEC1 (BHLHE40/STRA13/SHARP-2) is negatively associated with TNM stage in non-small-cell lung cancer and inhibits the proliferation through cyclin D1 in A549 and BE1 cells. Tumour Biol 2013-02-20 [PMID: 23423709]
Lin Q, Cong X, Yun Z. Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha Mol Cancer Res 2011-06-01 [PMID: 21571835] (WB, Human)	WB	Human
Liu Y, Sato F, Kawamoto T et al. Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells. Genes Cells;15(4):315-25. 2010-04-01 [PMID: 20236182] (WB, Human)	WB	Human
Lin Q, Cong X, Yun Z. Differential Hypoxic Regulation of Hypoxia-Inducible Factors 1{alpha} and 2{alpha}. J Cereb Blood Flow Metab;24(2):245-58. 2004-02-01 [PMID: 14747751]
Show All 43 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: UJJAL BHAWAL	IHC-P	Rat	06/28/2018	View Summary Application Immunohistochemistry-Paraffin Sample Tested Porphyromonas gingivalis-challenged rat maxilla Species Rat Lot C-2
Enlarge	5 reviewed by: Verified Customer	ChIP	Human	07/07/2016	View Summary Application Chromatin Immunoprecipitation Sample Tested Renal cell line Species Human

Array NB100-1800

• DEC1 Antibodies
• DEC1 Lysate
• DEC1 Proteins