PER2 Antibody - BSA Free

PER2 (period circadian protein homolog 2 or circadian clock protein PERIOD 2) is a component of the circadian clock mechanism which is essential for generating circadian rhythms and PER2 acts as a negative element in the circadian transcriptional loop. PER2 modulates the clock function by interacting with other circadian regulatory proteins for transporting them to nucleus, and negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. PER2 forms a component of the circadian core oscillator, which also includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS proteinsetc. PER2 interacts with NFIL3, PER1, PER3, CRY1 and CRY2 proteins, and its interaction with CSNK1D or CSNK1E promotes nuclear localization of PER proteins. PER2 is a nuclear protein and its nucleo-cytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. CSNK1E and CSNK1D facilitate PER2 phosphorylation that follows its degradation. PER2 defects have been found to be responsible for familial advanced sleep-phase syndrome (FASPS).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 6 applications: IHC-P, IP, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, WB, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NB100-125	Applications	Species
Ding Z, Ge W, Xu X et al. PER2/P65-driven glycogen synthase 1 transcription in macrophages modulates gut inflammation and pathogenesis�of rectal prolapse J Biol Chem 2023-09-01 [PMID: 37660913]
Shearn, CT;Anderson, AL;Devereaux, MW;El Kasmi, KC;Orlicky, DJ;Sokol, RJ; Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition PloS one 2023-08-30 [PMID: 37647292] (Western Blot)	Western Blot
Fu J, Fan Z, He L et al. Circadian clock disruption in autoimmune thyroiditis European Thyroid Journal 2023-10-01 [PMID: 37548297] (Immunohistochemistry, Immunocytochemistry/ Immunofluorescence)	Immunohistochemistry, Immunocytochemistry/ Immunofluorescence
Oyama y, Shuff SR, Burns N et al. Intense light elicited alveolar type 2 specific circadian PER2 protects from bacterial lung injury via BPIFB1 American journal of physiology. Lung cellular and molecular physiology 2022-03-10 [PMID: 35272486] (WB, Mouse)	WB	Mouse
Sheng-Long Ding, Tai-Wei Zhang, Qi-Chen Zhang, Wang Ding, Ze-Fang Li, Guan-Jie Han, Jin-Song Bai, Xi-Lei Li, Jian Dong, Hui-Ren Wang, Li-Bo Jiang Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm Experimental & Molecular Medicine 2021-12-21 [PMID: 34934193]
de Zavalia N, Schoettner K, Goldsmith JA Et al. Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner Communications biology 2021-10-26 [PMID: 34702951]
Li S, Zhai J, Chu W et al. Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome Transl Res 2020-02-12 [PMID: 32119846] (WB, Rat) Details: Sprague-Dawley Rats	WB	Rat
Zhang XY, Wang L, Yan WJ et al. Period 2-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction Hum. Gene Ther. 2019-12-10 [PMID: 31822134] (IHC-P, Mouse)	IHC-P	Mouse
Oyama Y, Bartman CM, Bonney S et al. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium Cell Rep 2019-08-08 [PMID: 31390562] (IP, Human)	IP	Human
Dong E, Guidotti A, Zhang H et al. Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring Neuropharmacology 2018-09-15 [PMID: 30016666] (WB, Mouse)	WB	Mouse
Lee Y, Jang AR, Francey LJ et al. KPNB1 mediates PER/CRY nuclear translocation and circadian clock function. Elife 2015-01-01 [PMID: 26319354] (WB)	WB
Show All 11 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	2 reviewed by: Katharina Sahiri	WB	Human	02/21/2019	View Summary Application Western Blot Sample Tested U-2 OS cells Species Human Lot E Comments Comments unspecific bands with no obvious band of correct size
Enlarge	5 reviewed by: Verified Customer	WB	Human	11/12/2017	View Summary Application Western Blot Sample Tested Human cancer cell line Species Human Lot D-1 Comments Comments Sample: Whole cell lysates of cancer cell lines (10ug) Blocking: 5% nonfat dry milk reconstituted in TBS-T for 1 hour at room temperature Primary Antibody diluted (1:500) in 5% nonfat dry milk reconstituted in TBS-T overnight at 4deg C Secondary Antibody: Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilution in TBS-T
Enlarge	4 reviewed by: Verified Customer	WB	Human	12/10/2014	View Summary Application Western Blot Sample Tested Whole cell lysates of various cancer cell lines Species Human Lot C-1

Array NB100-125

• PER2 Antibodies
• PER2 ELISA Kits
• PER2 Proteins