PER1 Antibody

Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein-mediated, autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Amphibian.

We have publications tested in 3 applications: IB, KO, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP2-24589	Applications	Species
Singh G Role of Glucose-induced Transcription Factor Signalling and Mitochondrial Epigenetics in Stress Tolerant Wood Frog, Rana sylvatica Thesis 2022-12-16 (WB, Amphibian) Details: Wood Frog	WB	Amphibian
Colleen M. Bartman, Lisa Nesbitt, Kenge K. Lee, Latifa Khalfaoui, Yun‐Hua Fang, Christina M. Pabelick, Y. S. Prakash BMAL1 sex‐specific effects in the neonatal mouse airway exposed to moderate hyperoxia Physiological Reports 2024-06-28 [PMID: 38942729]
Toledo M, Batista-Gonzalez A, Merheb E et al. Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY2 Cell Metab. 2018-08-07 [PMID: 29937374] (IB, Mouse)	IB	Mouse
Hamilton K. Basic Helix Loop Helix Enhancer 40 in Neuronal Excitability and Synaptic Plasticity Dissertation 2016-01-01 (KO, WB, Mouse)	KO, WB	Mouse

Images	Ratings	Applications	Species	Date	Details
	1 reviewed by: Verified Customer	IHC-Fr	Other	09/11/2023	View Summary Application Immunohistochemistry-Frozen Sample Tested brain section Species Other Lot 03253611A-2 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.***
Enlarge	2 reviewed by: Katharina Sahiri	WB	Human	02/21/2019	View Summary Application Western Blot Sample Tested U-2 OS cells Species Human Lot 03253611A Comments Comments unspecific bands with no obvious band of correct size

Array NBP2-24589

• PER1 Antibodies
• PER1 Proteins