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CXCR7/RDC-1 Antibody (896032) [Unconjugated]

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HEK293 human embryonic kidney cell line transfected with (A) rat CXCR7/RDC-1 or (B) irrelevant transfectants and eGFP was stained with Mouse Anti-Rat CXCR7/RDC‑1 Monoclonal Antibody (Catalog # MAB8399) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B). Quadrant markers were set based on control antibody staining (Catalog # MAB003).
HEK293 human embryonic kidney cell line transfected with (A) rat CXCR7/RDC-1 or (B) irrelevant transfectants and eGFP was stained with Mouse Anti-Rat CXCR7/RDC‑1 Monoclonal Antibody (Catalog # MAB8399) followed by ...read more

Product Details

Summary
Reactivity RtSpecies Glossary
Applications Flow, CyTOF-ready
Clone
896032
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB8399U-100UG
Alexa Fluor 405
FAB8399V-100UG
Alexa Fluor 488
FAB8399G-100UG
Alexa Fluor 532
FAB8399X
Alexa Fluor 594
FAB8399T-100UG
Alexa Fluor 647
FAB8399R-100UG
Alexa Fluor 700
FAB8399N-100UG
Alexa Fluor 750
FAB8399S-100UG
Allophycocyanin/Cy7
FAB8399APCCY7
Biotin
FAB8399B
CoraFluor 1
FAB8399CL1
DyLight 350
FAB8399D
DyLight 405
FAB8399E
DyLight 488
FAB8399K
DyLight 550
FAB8399L
DyLight 594
FAB8399M
DyLight 650
FAB8399W
DyLight 680
FAB8399Y
DyLight 755
FAB8399Z
FITC
FAB8399F
HRP
FAB8399H
Janelia Fluor 525
FAB8399JF525
Janelia Fluor 549
FAB8399I
Janelia Fluor 585
FAB8399JF585
Janelia Fluor 635
FAB8399JF635
Janelia Fluor 646
FAB8399J
Janelia Fluor 669
FAB8399JF669
PE/Atto594
FAB8399PEATT594
PE/Cy5.5
FAB8399PECY55
PE/Cy7
FAB8399PECY7
PerCP
FAB8399C
mFluor Violet 450 SE
FAB8399MFV450
mFluor Violet 500 SE
FAB8399MFV500
mFluor Violet 610 SE
FAB8399MFV610
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB8399-SP
Carrier Free
FAB8399V-100UG
Carrier Free
FAB8399U-100UG
Carrier Free
FAB8399T-100UG
Carrier Free
FAB8399S-100UG
Carrier Free
FAB8399R-100UG
Carrier Free
FAB8399N-100UG
Carrier Free
FAB8399G-100UG
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CXCR7/RDC-1 Antibody (896032) [Unconjugated] Summary

Immunogen
NS0 mouse myeloma cell line transfected with rat CXCR7/RDC-1
Met1-Lys362
Accession # NP_445804
Specificity
Stains rat CXCR7/RDC-1 transfectants but not irrelevant transfectants in flow cytometry. 
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CXCR7
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCR7/RDC-1 Antibody (896032) [Unconjugated]

  • ACKR3
  • chemokine (C-X-C motif) receptor 7
  • Chemokine orphan receptor 1CMKOR1C-X-C chemokine receptor type 7
  • CMKOR1
  • CXCR7
  • CXC-R7
  • CXCR-7
  • G protein-coupled receptor
  • GPR159
  • GPR159G-protein coupled receptor 159
  • RDC-1
  • RDC1G-protein coupled receptor RDC1 homolog

Background

CXCR7 (CXC Chemokine Receptor 7), also known as GPRN1, RDC-1 and Chemokine Orphan Receptor 1, is a 60 kDa member of the G-protein coupled receptor 1 family. It is expressed on multiple cell types, including neurons, T cells, NK cells, neutrophils, B cells plus angiogenic endothelial cells. CXCR7 forms both homodimers and heterodimers with CXCR4. It selectively binds I-TAC and SDF-1, and appears to involve beta -Arrestin 2 during signaling. Notably, a CXCR7:CXCR4 heterodimer shows increased responsiveness to SDF-1, and I-TAC may actually block some SDF-1-mediated migration activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CXCR7
Uniprot