Human CD44 ELISA Kit (Colorimetric)

CD44 (Pgp-1; Ly-24; ECMR III; F10-44-2; H-CAM; HUTCH-I; In(Lu)- related p80; Hermes antigen; hyaluronan receptor) is a polymorphic glycoprotein with apparent molecular weights ranging from 85 kDa to 250 kDa. This cell membrane associated molecule has a cytoplasmic tail (mediates the interaction with the cytoskeleton), a short hydrophobic transmembrane region and an NH2-terminal extracellular (binds to hyaluronate) domain. CD44 isoforms participate in a wide variety of cell-cell or cell-matrix interactions including lymphocyte homing, establishment of B and T cell immune responses, tumor metastases formation and inflammation. Three isoform categories of the CD44 molecule have been identified: - an 80-90 kDa isoform, the so-called standard form named CD44std, which is widely distributed on several hematopoietic and nonhemato- poietic cells including all subsets of leukocytes, monocytes, erythrocytes, many types of epithelium, mesenchymal elements like fibroblasts, smooth muscle cells and glial cells of the central nervous system, - a medium size category of 110-160 kDa, which is weakly expressed on epithelial cells and highly expressed in some carcinomas, and - a category that includes very large isoforms of 250 kDa covalently modified by the addition of chondroitin sulfate. These bigger isoforms of CD44 arise by alternative splicing of one or more "variant" exons (v2-v10) into the extracellular part of the 90kDa constant form molecule. Compared to the standard CD44, all larger isoforms are expressed in a much more restricted fashion, only in a few normal tissues or on the surface of certain tumor cells. Some splice variants of CD44 play important and distinct roles in tumor metastasis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

We have publications tested in 1 application: ELISA.

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Publication using NBP1-86819	Applications	Species
Kassem MM, Vivian Gahtan MD Thrombospondins Differentially Regulate Proteins Involved in Arterial Remodeling Short Title: TSP induced Protein Expression Physiol Res 2019-10-25 [PMID: 31647293] (ELISA)	ELISA

Array NBP1-86819

• CD44 Antibodies
• CD44 Antibody Pair
• CD44 ELISA Kits
• CD44 Lysates
• CD44 Protein
• CD44 ELISA
• CD44 Proteins and Enzymes