CCR7 Antibody (4B12) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCR7 (Chemokine Receptor 7; also CD197) is a 7 transmembrane (7TM) G protein-coupled chemokine receptor for the homeostatic chemokines CCL19/MIP-3 beta and CCL21/6Ckine. CCL19 and CCL21 are constitutively expressed by high endothelial venule epithelial cells or fibroblastic reticular cells in secondary lymphoid organs. CCR7 is upregulated on dendritic cells, naïve and memory T cells, Treg, NK cells, and B cells following inflammatory stimulation. Its expression enables the function of immune cell trafficking to and retention in regional lymph nodes for expansion of the adaptive immune response. Mouse CCR7 shares 87% amino acid sequence identity with human CCR7.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 6 applications: ELISA Development, Flow Cytometry, ICC, IHC, In Vivo, Neutralization.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using MAB3477	Applications	Species
Artusa, P;Nguyen Yamamoto, L;Barbier, C;Valbon, SF;Aghazadeh Habashi, Y;Djambazian, H;Ismailova, A;Lebel, MÈ;Salehi-Tabar, R;Sarmadi, F;Ragoussis, J;Goltzman, D;Melichar, HJ;White, JH; Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin D signaling Science advances 2024-09-27 [PMID: 39321290] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Yee Mon, KJ;Kim, S;Dai, Z;West, JD;Zhu, H;Jain, R;Grimson, A;Rudd, BD;Singh, A; Functionalized nanowires for miRNA-mediated therapeutic programming of naïve T cells Nature nanotechnology 2024-04-29 [PMID: 38684809] (Flow Cytometry, Transgenic Mouse)	Flow Cytometry	Transgenic Mouse
Wasman Smail, S;Ziyad Abdulqadir, S;Omar Khudhur, Z;Elia Ishaq, S;Faqiyazdin Ahmed, A;Ghayour, MB;Abdolmaleki, A; IL-33 promotes sciatic nerve regeneration in mice by modulating macrophage polarization International immunopharmacology 2023-07-31 [PMID: 37531832] (IHC, Mouse)	IHC	Mouse
J Liu, Y Cheng, X Zhang, Y Chen, H Zhu, K Chen, S Liu, Z Li, X Cao Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity Cell Reports, 2023-01-18;42(1):111991. 2023-01-18 [PMID: 36656709] (In Vivo, Mouse)	In Vivo	Mouse
Bingjun Zhang, Fei Han, Yufeng Wang, Yuhua Sun, Meng Zhang, Xiaopeng Yu et al. Cells‐Micropatterning Biomaterials for Immune Activation and Bone Regeneration Advanced Science 6/1/2022 [PMID: 35478383]
I Del Molino, A Meeson, K Cooke, MI Malki, B Barron-Mil, JA Kirby, S Ali Contribution of Heparan Sulphate Binding in CCL21-Mediated Migration of Breast Cancer Cells Cancers, 2021-07-10;13(14):. 2021-07-10 [PMID: 34298676] (ICC, Mouse)	ICC	Mouse
Juana Serrano-Lopez, Shailaja Hegde, Sachin Kumar, Josefina Serrano, Jing Fang, Ashley M Wellendorf et al. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics eLife 4/8/2021 [PMID: 33830019]
FY Mao, YP Lv, CJ Hao, YS Teng, YG Liu, P Cheng, SM Yang, W Chen, T Liu, QM Zou, R Xie, JY Xu, Y Zhuang Helicobacter pylori-induced Rev-erb&alpha fosters gastric bacteria colonization by impairing host innate and adaptive defense Cellular and Molecular Gastroenterology and Hepatology, 2021-03-03;0(0):. 2021-03-03 [PMID: 33676046] (Neutralization, Mouse)	Neutralization	Mouse
EJ Park, PK Myint, MG Appiah, P Worawattan, J Inprasit, O Prajuabjin, ZY Soe, A Gaowa, E Kawamoto, M Shimaoka Ligand-competent fractalkine receptor is expressed on exosomes Biochemistry and Biophysics Reports, 2021-02-02;26(0):100932. 2021-02-02 [PMID: 33553692] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Caroline Spenlé, Thomas Loustau, Devadarssen Murdamoothoo, William Erne, Stephanie Beghelli-de la Forest Divonne, Romain Veber et al. Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma Cancer Immunology Research 9/1/2020 [PMID: 32665262]
Saria Mcheik, Nils Van Eeckhout, Cédric De Poorter, Céline Galés, Marc Parmentier, Jean-Yves Springael Coexpression of CCR7 and CXCR4 During B Cell Development Controls CXCR4 Responsiveness and Bone Marrow Homing Frontiers in Immunology 12/18/2019 [PMID: 31921208]
Chen S, Ge L, Wang H et al. Eluted 25-hydroxyvitamin D3 from radially aligned nanofiber scaffolds enhances cathelicidin production while reducing inflammatory response in human immune system-engrafted mice Acta Biomater 8/3/2019 [PMID: 31386930]
G Pei, Y Yao, Q Yang, M Wang, Y Wang, J Wu, P Wang, Y Li, F Zhu, J Yang, Y Zhang, W Yang, X Deng, Z Zhao, H Zhu, S Ge, M Han, R Zeng, G Xu Lymphangiogenesis in kidney and lymph node mediates renal inflammation and fibrosis Sci Adv, 2019-06-26;5(6):eaaw5075. 2019-06-26 [PMID: 31249871] (In Vivo, Mouse)	In Vivo	Mouse
Pang M, Georgoudaki A, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander J, Nelson C, Jakobsson L, Betsholtz C, Sund M, Karlsson M, Fuxe J TGF-beta1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis. Oncogene, 2015-05-11;35(6):748-60. 2015-05-11 [PMID: 25961925] (Neutralization, Mouse)	Neutralization	Mouse
Dong G, Wang Y, Xiao W, Pacios Pujado S, Xu F, Tian C, Xiao E, Choi Y, Graves D FOXO1 regulates dendritic cell activity through ICAM-1 and CCR7. J Immunol, 2015-03-18;194(8):3745-55. 2015-03-18 [PMID: 25786691] (IHC, Mouse)	IHC	Mouse
Ibrahim M, Barnes J, Osorio E, Anstead G, Jimenez F, Osterholzer J, Travi B, Ahuja S, White A, Melby P Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection. Infect Immun, 2014-05-12;82(8):3098-112. 2014-05-12 [PMID: 24818662] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Irino , Tomoyuki, Takeuchi , Hiroya, Matsuda , Sachiko, Saikawa , Yoshiro, Kawakubo , Hirofumi, Wada , Norihito, Takahashi , Tsunehir, Nakamura , Rieko, Fukuda , Kazumasa, Omori , Tai, Kitagawa , Yuko CC-Chemokine receptor CCR7: a key molecule for lymph node metastasis in esophageal squamous cell carcinoma. BMC Cancer, 2014-04-26;14(0):291. 2014-04-26 [PMID: 24766770] (ELISA Development, Human)	ELISA Development	Human
Wan S, Zhou Z, Duan B, Morel L Direct B cell stimulation by dendritic cells in a mouse model of lupus. Arthritis Rheum., 2008-06-01;8(0):1741-50. 2008-06-01 [PMID: 18512810] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Show All 18 Publications. Collapse Publications.

Array MAB3477

• CCR7 Antibodies
• CCR7 ELISA Kits
• CCR7 Lysate
• CCR7 Proteins