CCL2/MCP1 Antibody - BSA Free

MCP-1 (monocyte chemoattracctant protein-1, also called C-C motif chemokine 2 or CCL2) is a secreted protein belonging to the intercrine beta (chemokine CC) family and specifically acts as a chemotactic factor to attract monocytes, CD4+ T cells, NK cells, and CCR2 expressing cells, but not neutrophils. Both hematopoietic and non-hematopoietic cells that include monocytes/macrophages, dendritic cells, astrocytes, endothelial cells and fibroblasts express MCP-1, and monocytes/macrophages are the major source of MCP-1 in peripheral blood. In addition to expression at acute inflammation sites, MCP-1 is upregulated in chronic inflammation, including autoimmune disease, atherosclerosis, cancer, and chronic infection. MCP-1 has been implicated in both pro-inflammatory and anti-inflammatory responses, and is a potential intervention point for the treatment of various inflammatory/autoimmune diseases (multiple sclerosis, atherosclerosis, insulin-resistant diabetes, rheumatoid arthritis and lupus nephritis), cancers (breast and prostate cancer) and HIV-1/AIDS.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 9 applications: B/N, ELISA, ICC/IF, IF/IHC, IHC-Fr, IHC-P, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, WB.

Showing Publications 1 - 10 of 23. Show All 23 Publications. Collapse Publications.

Publications using NBP1-07035	Applications	Species
T. Ollewagen, R.M. Benecke, C. Smith High species homology potentiates quantitative inflammation profiling in zebrafish using immunofluorescence Heliyon 2023-12-13 [PMID: 38187273]
Deng S, Zhou F, Wang F et al. C5a enhances V?1 T cells recruitment via the CCL2-CCR2 axis in IgA nephropathy International immunopharmacology 2023-10-18 [PMID: 37862725] (Human) Details: HMC Stimulation		Human
Wilkinson A, Hulme S, Kennedy J et al. The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration iScience 2023-09-01 [PMID: 37810232]
Lee C, Cho S, Jeong D Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring KLF4 Expression Preprint 2023-07-11 [PMID: 37569807] (WB)	WB
Torres-Arévalo, Á;Nahuelpán, Y;Muñoz, K;Jara, C;Cappelli, C;Taracha-Wiśniewska, A;Quezada-Monrás, C;Martín, RS; A2BAR Antagonism Decreases the Glomerular Expression and Secretion of Chemoattractants for Monocytes and the Pro-Fibrotic M2 Macrophages Polarization during Diabetic Nephropathy International journal of molecular sciences 2023-06-29 [PMID: 37446007] (ELISA)	ELISA
Andre AB, Rees KP, O'Connor S et al. Single cell analysis reveals satellite cell heterogeneity for proinflammatory chemokine expression Frontiers in cell and developmental biology 2023-03-27 [PMID: 37051469] (IHC-P, Mouse) Details: 1:500 IHC-P dilution	IHC-P	Mouse
Zhu X, Schrader JM, Irizarry BA et al. Impact of A beta 40 and A beta 42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia Biomedicines 2022-11-19 [PMID: 36428550] (IHC-Fr, Rat) Details: Fifteen-month-old rTgF344-AD rat brain sections, dilution used 1:200	IHC-Fr	Rat
Merckx C, Zsch�ntzsch J, Meyer S et al. Exploring the Therapeutic Potential of Ectoine in Duchenne Muscular Dystrophy: Comparison with Taurine, a Supplement with Known Beneficial Effects in the mdx Mouse International Journal of Molecular Sciences 2022-08-24 [PMID: 36076964] (Immunocytochemistry/ Immunofluorescence)	Immunocytochemistry/ Immunofluorescence
Shi, X;Gong, X;Xiong, H;Zhang, J; Cellular distribution of C-C motif chemokine ligand 2 like immunoreactivities in frontal cortex and corpus callosum of normal and lipopolysaccharide treated animal BMC Neuroscience [PMID: 35354428] (ICC/IF)	ICC/IF
Ollewagen T, Powrie YSL, Myburgh KH, Smith C Unresolved intramuscular inflammation, not diminished skeletal muscle regenerative capacity, is at the root of rheumatoid cachexia: insights from a rat CIA model Physiological reports 2021-11-01 [PMID: 34806343] (WB, Rat)	WB	Rat
Zhu X, Xie W, Zhang J et al. Sympathectomy decreases pain behaviors and nerve regeneration by downregulating monocyte chemokine CCL2 in dorsal root ganglia in the rat tibial nerve crush model Pain 2022-01-01 [PMID: 33941753] (Immunohistochemistry)	Immunohistochemistry
Yitong Zhao, Masaki Goto, Nosratola D Vaziri, Mahyar Khazaeli, Han Liu, Nazli Farahanchi, Elham Khanifar, Ted Farzaneh, Patrick A Haslett, Hamid Moradi, Mangala M Soundarapandian RNA Interference Targeting Liver Angiopoietin-Like Protein 3 Protects from Nephrotic Syndrome in a Rat Model Via Amelioration of Pathologic Hypertriglyceridemia. The Journal of pharmacology and experimental therapeutics 2021-04-27 [PMID: 33443084]
Zheng Y, Lu P, Deng Y et al. Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy Cell reports 2020-12-22 [PMID: 33357427] (ICC/IF, Human)	ICC/IF	Human
Wu J, Dou Y, Ladiges W Adverse neurological effects of short-term sleep deprivation in aging mice are prevented by SS31 peptide Clocks Sleep 2020-10-22 [PMID: 33089207]
Zhao L, Fan M, Zhao L et al. Fibroblast growth factor 1 ameliorates adipose tissue inflammation and systemic insulin resistance via enhancing adipocyte mTORC2/Rictor signal J. Cell. Mol. Med. 2020-09-26 [PMID: 32979037] (IHC-P, WB, Mouse)	IHC-P, WB	Mouse
Chen I-Chen, Lin Yu-Tsai, Huang Jhy-Shrian et al. Decreased Ambient Oxygen Tension Alters the Expression of Endothelin-1, iNOS and cGMP in Rat Alveolar Macrophages. International Journal of Medical Sciences 2019-02-28 [PMID: 30911278] (WB, Rat)	WB	Rat
Alghamdi TA, Batchu SN, Hadden MJ, et al. Histone H3 Serine 10 Phosphorylation Facilitates Endothelial Activation in Diabetic Kidney Disease Diabetes 2018-12-01 [PMID: 30213824] (WB, Mouse)	WB	Mouse
Yang X, Wei J, He Y et al. SIRT1 inhibition promotes atherosclerosis through impaired autophagy Oncotarget 2017-08-01 [PMID: 28881659] (ICC/IF, Human)	ICC/IF	Human
Verzola D, Milanesi S, Bertolotto M et al. Myostatin mediates abdominal aortic atherosclerosis progression by inducing vascular smooth muscle cell dysfunction and monocyte recruitment. Scientific Reports 2017-01-01 [PMID: 28406165] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Deng W, Mao L, Yu G et al. LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma. Oncoimmunology 2016-10-07 [PMID: 27999760] (WB, Mouse)	WB	Mouse
Choi JA, Chung YR, Byun HR et al. The anti-ALS drug riluzole attenuates pericyte loss in the diabetic retinopathy of streptozotocin-treated mice. Toxicol Appl Pharmacol 2017-01-15 [PMID: 27939241] (Mouse)		Mouse
Lamont EA, O'Grady SM, Davis WC et al. Infection with Mycobacterium avium subsp. paratuberculosis Results in Rapid Interleukin-1 beta Release and Macrophage Transepithelial Migration Infect Immun 2012-09-01 [PMID: 22778093] (B/N, Human)	B/N	Human
Fet NG, Fiebeler A, Klinge U et al. Reduction of activated macrophages after ischaemia-reperfusion injury diminishes oxidative stress and ameliorates renal damage Nephrol Dial Transplant 2012-03-08 [PMID: 22402584] (IF/IHC, Rat)	IF/IHC	Rat
Show All 23 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	10/23/2017	View Summary Application Western Blot Sample Tested Mouse Head and neck squamous cell carcinoma (HNSCC) Species Mouse Lot NBP1-07035

Array NBP1-07035

• CCL2/MCP1 Antibodies
• CCL2/MCP1 ELISA Kits
• CCL2/MCP1 Lysate
• CCL2/MCP1 Proteins