Cathepsin L Antibody (204101) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cathepsin L is a lysosomal cysteine protease expressed in most eukaryotic cells. Cathepsin L is known to hydrolyze a number of proteins, including the proform of urokinase-type plasminogen activator, which is activated by Cathepsin L cleavage (1). Cathepsin L has also been shown to proteolytically inactivate alpha 1-antitrypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract (2). These observations, combined with the demonstration of increased Cathepsin L activity in the epithelial lining fluid of the lungs of emphysema patients, have led to the suggestion that the enzyme may be involved in the progression of this disease. Cathepsin L has also been identified as a major excreted protein of transformed fibroblasts, indicating the enzyme could be involved in malignant tumor growth (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IHC, IHC-P, Western Blot.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using MAB9521	Applications	Species
Y Li, JW Jones, H M C Choi, C Sarkar, MA Kane, EY Koh, MM Lipinski, J Wu cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury Cell Death Dis, 2019-07-11;10(7):531. 7/11/2019 [PMID: 31296844]
C Sarkar, JW Jones, N Hegdekar, JA Thayer, A Kumar, AI Faden, MA Kane, MM Lipinski PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma Autophagy, 2019-06-25;0(0):1-20. 2019-06-25 [PMID: 31238788] (IHC, Mouse)	IHC	Mouse
CCT complex restricts neuropathogenic protein aggregation via autophagy Nat Commun, 2016-12-08;7(0):13821. 2016-12-08 [PMID: 27929117] (Western Blot, Human)	Western Blot	Human
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy Sci Adv, 2016-09-02;2(9):e1601167. 2016-09-02 [PMID: 27617292] (Western Blot, Mouse)	Western Blot	Mouse
Pensa S, Neoh K, Resemann H, Kreuzaler P, Abell K, Clarke N, Reinheckel T, Kahn C, Watson C The PI3K regulatory subunits p55alpha and p50alpha regulate cell death in vivo. Cell Death Differ, 2014-06-06;21(9):1442-50. 2014-06-06 [PMID: 24902901] (IHC-P, Western Blot, Mouse)	IHC-P, Western Blot	Mouse
Jonathan J. Campbell, Laur-Alexandru Botos, Timothy J. Sargeant, Natalia Davidenko, Ruth E. Cameron, Christine J. Watson A 3-D in vitro co-culture model of mammary gland involution Integr Biol (Camb) 2014-04-12 [PMID: 24722402]
O'Brien J, Martinson H, Durand-Rougely C Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution. Development, 2011-11-30;139(2):269-75. 2011-11-30 [PMID: 22129827] (Western Blot, Mouse)	Western Blot	Mouse
Kreuzaler PA, Staniszewska AD, Li W, Omidvar N, Kedjouar B, Turkson J, Poli V, Flavell RA, Clarkson RW, Watson CJ Stat3 controls lysosomal-mediated cell death in vivo. Nat. Cell Biol., 2011-02-20;13(3):303-9. 2011-02-20 [PMID: 21336304] (Western Blot, Mouse)	Western Blot	Mouse
Lopez-Castejon G, Theaker J, Pelegrin P P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases. J. Immunol., 2010-07-16;185(4):2611-9. 2010-07-16 [PMID: 20639492] (Western Blot, Human, Mouse)	Western Blot	Human, Mouse
Zeeuwen PL, van Vlijmen-Willems IM, Cheng T The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea. FASEB J., 2010-05-21;24(10):3744-55. 2010-05-21 [PMID: 20495178] (IHC-P, Mouse)	IHC-P	Mouse
Parker BS, Ciocca DR, Bidwell BN, Gago FE, Fanelli MA, George J, Slavin JL, Moller A, Steel R, Pouliot N, Eckhardt BL, Henderson MA, Anderson RL Primary tumour expression of the cysteine cathepsin inhibitor Stefin A inhibits distant metastasis in breast cancer. J. Pathol., 2008-02-01;214(3):337-46. 2008-02-01 [PMID: 17985332] (IHC-P, Mouse)	IHC-P	Mouse
Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J. Biol. Chem., 2006-03-24;281(23):15893-9. 2006-03-24 [PMID: 16565075] (IHC, Human)	IHC	Human
Show All 12 Publications. Collapse Publications.

Array MAB9521

• Cathepsin L Antibodies
• Cathepsin L ELISA Kits
• Cathepsin L Lysates
• Cathepsin L Protein
• Cathepsin L ELISA
• Cathepsin L Proteins and Enzymes