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Cathepsin V Antibody (182016) [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IP
Clone
182016
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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Cathepsin V Antibody (182016) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Cathepsin V
Accession # O60911
Specificity
Detects human Cathepsin V in direct ELISAs and Western blots. In Western blots, approximately 50% cross-reactivity with recombinant mouse (rm) Cathepsin H and recombinant human (rh) Cathepsin K is observed and no cross-reactivity with rhCathepsin B, C, L, O, S, Z, rmCathepsin B, C, F, or Z is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CTSL2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 8-25 ug/mL
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB1080 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cathepsin V Antibody (182016) [Unconjugated]

  • Cathepsin L2
  • Cathepsin U
  • Cathepsin V
  • CATL2
  • CTSL2
  • CTSUcathepsin L2, preproprotein
  • CTSVMGC125957
  • EC 3.4.22
  • EC 3.4.22.43

Background

Cathepsin V (also known as Cathepsin L2 and U) is a cysteine protease of the papain family (1). It is expressed as a proenzyme in lysosomes, which can be autocatalytically converted to the mature form at pH 4.0 (2). Cathepsin V shows high amino acid identity with Cathepsin L (77% for the proenzymes and 80% for the mature enzymes) (3). However, Cathepsin V is specifically expressed in the thymus, testis, and corneal epithelium whereas Cathepsin L is expressed throughout the body.

  1. Turk, V. et al. (2001) EMBO J. 20:4629.
  2. Bromme, D. et al. (1999) Biochemistry 38:2377.
  3. Somoza, J.R. et al. (2000) Biochemistry 39:12543.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Cathepsin V Antibody (MAB1080)(6)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ICC, IHC, IHC-P, Western Blot.


Filter By Application
ICC
(1)
IHC
(1)
IHC-P
(2)
Western Blot
(2)
All Applications
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Human
(3)
Mouse
(2)
All Species
Showing Publications 1 - 6 of 6.
Publications using MAB1080 Applications Species
Alaa Al-Hashimi, Vaishnavi Venugopalan, Maren Rehders, Naphannop Sereesongsaeng, Zeynep Hein, Sebastian Springer et al. Procathepsin V Is Secreted in a TSH Regulated Manner from Human Thyroid Epithelial Cells and Is Accessible to an Activity-Based Probe International Journal of Molecular Sciences 11/30/2020 [PMID: 33266306]
Bergboer JG, Tjabringa GS, Kamsteeg M, van Vlijmen-Willems IM, Rodijk-Olthuis D, Jansen PA, Thuret JY, Narita M, Ishida-Yamamoto A, Zeeuwen PL, Schalkwijk J Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups. Am. J. Pathol., 2011-04-01;178(4):1470-7. 2011-04-01 [PMID: 21435436] (IHC-P, Human) IHC-P Human
Tedelind S, Poliakova K, Valeta A Nuclear cysteine cathepsin variants in thyroid carcinoma cells. Biol. Chem., 2010-08-01;391(8):923-35. 2010-08-01 [PMID: 20536394] (ICC, Western Blot, Mouse) ICC, Western Blot Mouse
Spira D, Stypmann J, Tobin DJ, Petermann I, Mayer C, Hagemann S, Vasiljeva O, Gunther T, Schule R, Peters C, Reinheckel T Cell type-specific functions of the lysosomal protease cathepsin L in the heart. J. Biol. Chem., 2007-10-17;282(51):37045-52. 2007-10-17 [PMID: 17942402] (IHC-P, Mouse) IHC-P Mouse
Ma DH, Yao JY, Kuo MT, See LC, Lin KY, Chen SC, Chen JK, Chao AS, Wang SF, Lin KK Generation of endostatin by matrix metalloproteinase and cathepsin from human limbocorneal epithelial cells cultivated on amniotic membrane. Invest. Ophthalmol. Vis. Sci., 2007-02-01;48(2):644-51. 2007-02-01 [PMID: 17251461] (Western Blot, Human) Western Blot Human
Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J. Biol. Chem., 2006-03-24;281(23):15893-9. 2006-03-24 [PMID: 16565075] (IHC, Human) IHC Human

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Bioinformatics

Gene Symbol CTSL2
Uniprot