Western Blot: Transglutaminase 3/TGM3 Antibody [NBP1-86950] - Analysis in human cell line EFO-21.
Immunohistochemistry-Paraffin: Transglutaminase 3/TGM3 Antibody [NBP1-86950] - Staining of human esophagus shows high expression.
Immunohistochemistry-Paraffin: Transglutaminase 3/TGM3 Antibody [NBP1-86950] - Staining of human lymph node shows no positivity in germinal center cells and non-germinal center cells as expected.
Immunohistochemistry-Paraffin: Transglutaminase 3/TGM3 Antibody [NBP1-86950] - Staining of human skin shows weak cytoplasmic positivity in squamous epithelial cells.
Transglutaminase 3/TGM3 Antibody [NBP1-86950]-Staining of human skeletal muscle shows negative cytoplasmic positivity in myocytes as expected.
This antibody was developed against Recombinant Protein corresponding to amino acids: GSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQEPSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYEKYLKSDNMI
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TGM3
Purity
Immunogen affinity purified
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for Transglutaminase 3/TGM3 Antibody
EC 2.3.2.13
MGC126250
protein-glutamine gamma-glutamyltransferase E
TG(E)
TG3
TGase E
TGase-3
TgaseE
TGEMGC126249
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
Transglutaminase 3
Transglutaminase E
transglutaminase-3
Background
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium dependent. Transglutaminase 3 consists of two polypeptide chains activated from a single precursor protein by proteolysis. Transglutaminase 3 is involved the later stages of cell envelope formation in the epidermis and hair follicle.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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