Caspase 5 Antibody - BSA Free

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18. Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1beta. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP1-77209	Applications	Species
Wang X, Ni J, You Y Et al. SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade The EMBO journal 2021-11-08 [PMID: 34747049]
Goos H, Fogarty CL, Sahu B et al. Gain-of-function CEBPE mutation causes non-canonical autoinflammatory inflammasomopathy J Allergy Clin Immunol. 2019-06-12 [PMID: 31201888] (WB, Human)	WB	Human
Bian F, Pelegrino FS, Henriksson JT et al. Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye. Ocul Surf 2016-04-01 [PMID: 26772899]
Bian F, Pelegrino FS, Pflugfelder SC et al. Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas. Invest Ophthalmol Vis Sci 2015-07-01 [PMID: 26225631] (IF/IHC)	IF/IHC

Array NBP1-77209

• Caspase 5 Antibodies
• Caspase 5 ELISA Kits
• Caspase 5 Lysate
• Caspase 5 Proteins