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BMPR-IA/ALK-3 Antibody [Phycoerythrin]

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PC-3 human prostate cancer cell line was stained with Goat Anti-Human BMPR-IA/ALK-3 PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB346P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.
PC-3 human prostate cancer cell line was stained with Goat Anti-Human BMPR-IA/ALK-3 PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB346P, filled histogram) or isotype control antibody (Catalog ...read more

Product Details

Summary
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    • Catalog Number
      FAB346P
    • Availability
      Product Discontinued

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BMPR-IA/ALK-3 Antibody [Phycoerythrin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human BMPR-IA/AKL-3
Gln24-Arg152
Accession # P36894
Specificity
Detects human BMPR-IA in direct ELISAs and Western blots. In direct ELISAs, approximately 15% cross-reactivity with recombinant mouse BMPR-IA is observed, and less than 5% cross-reactivity with recombinant human (rh) BMPR‑IB and rhBMP RII is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
BMPR1A
Purity Statement
Antigen Affinity-purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publications using
FAB346P in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BMPR-IA/ALK-3 Antibody [Phycoerythrin]

  • ACVRLK310q23del
  • ALK-3
  • ALK3EC 2.7.11.30
  • BMP type-1A receptor
  • BMPR1A
  • BMPR-1A
  • BMPRIA
  • BMPR-IA
  • bone morphogenetic protein receptor type-1A
  • bone morphogenetic protein receptor, type IA
  • CD292 antigen
  • CD292
  • EC 2.7.11
  • Serine/threonine-protein kinase receptor R5
  • SKR5
  • type II-like kinase 3

Background

Cellular responses to Bone Morphogenetic Proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP Receptor 1A (BMPR-1A), also known as Activin Receptor-Like Kinase 3 (ALK-3), is one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-beta family cytokines. In contrast to the TGF-beta receptor system in which the type I receptor does not bind TGF-beta  in the absence of the type II receptor, type I receptors involved in BMP signaling (including BMPR-IA, BMPR-IB/ALK-6, and ActR-I/ALK-2) can independently bind the various BMP family proteins in the absence of type II receptors. Recombinant soluble BMPR-IA binds BMP-4 with high-affinity in solution and is a potent BMP-4 antagonist in vitro. BMPR-IA is ubiquitously expressed during embryogenesis. In adult tissues, BMPR-IA mRNA is also widely distributed with the highest expression levels found in skeletal muscle. The extracellular domain of BMPR-IA shares little amino acid sequence identity with the other mammalian ALK type I receptor kinases, but the cysteine residues are conserved. Human and mouse BMPR-IA are highly conserved and share 98% sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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BMPR-IA/ALK-3
Antibody [Phycoerythr
FAB346P
BMPR-IA/ALK-3 Antibody [Phycoerythrin]
Species: Hu
Applications: Flow

Publications for BMPR-IA/ALK-3 Antibody (FAB346P)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.


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Bioinformatics

Gene Symbol BMPR1A
Uniprot