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BMI-1 Antibody [DyLight 594]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ch, Fe, Pm, Rb, ZeSpecies Glossary
Applications WB, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 594

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB110-40823AF350
Alexa Fluor 405
NB110-40823AF405
Alexa Fluor 488
NB110-40823AF488
Alexa Fluor 532
NB110-40823AF532
Alexa Fluor 594
NB110-40823AF594
Alexa Fluor 647
NB110-40823AF647
Alexa Fluor 700
NB110-40823AF700
Alexa Fluor 750
NB110-40823AF750
Allophycocyanin
NB110-40823APC
Biotin
NB110-40823B
DyLight 350
NB110-40823UV
DyLight 405
NB110-40823V
DyLight 488
NB110-40823G
DyLight 550
NB110-40823R
DyLight 650
NB110-40823C
DyLight 680
NB110-40823FR
DyLight 755
NB110-40823IR
FITC
NB110-40823F
HRP
NB110-40823H
Janelia Fluor 549
NB110-40823JF549
Janelia Fluor 646
NB110-40823JF646
PE
NB110-40823PE
PerCP
NB110-40823PCP
Unconjugated
NB110-40823
mFluor Violet 450 SE
NB110-40823MFV450
mFluor Violet 500 SE
NB110-40823MFV500
mFluor Violet 610 SE
NB110-40823MFV610
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BMI-1 Antibody [DyLight 594] Summary

Immunogen
A synthetic peptide made to an internal region (within residues 1-100) of human Bmi1. [Swiss-Prot# P35226]
Localization
Nuclear
Predicted Species
Rat (92%), Chicken (92%), Primate (92%), Bovine (92%), Rabbit (92%), Feline (92%), Zebrafish (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
BMI1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: primate, feline, chicken, bovine, rabbit, rat and Zebrafish protein (all 92%).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for BMI-1 Antibody [DyLight 594]

  • B lymphoma Mo-MLV insertion region 1 homolog (mouse)
  • B lymphoma Mo-MLV insertion region 1 homolog
  • BMI1 polycomb ring finger oncogene
  • BMI1
  • BMI-1
  • FLVI2/BMI1
  • MGC12685
  • murine leukemia viral (bmi-1) oncogene homolog
  • PCGF4
  • polycomb complex protein BMI-1
  • polycomb group protein Bmi1
  • polycomb group ring finger 4
  • RING finger protein 51
  • RNF51
  • RNF51Polycomb group RING finger protein 4

Background

Bmi1 polycomb ring finger oncogene regulates the cell cycle inhibitor genes p16 and p19, with implications in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. Bmi 1 has been shown to induce telomerase activity and immortalize human mammary epithelial cells, and extend the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi-1 is also required for efficient self-renewing cell division in adult hematopoietic and neural stem cells.

Aberrant expression of Bmi-1 has been found in several types of cancer in the bladder, skin, blood, prostate, breast, ovaries, andcolon. Its overexpression is especially pronounced in mantle cell lymphomas. Thereforem Bmi1 antibodies will be useful tools for many cancer development studies.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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(3 Publications)
Species: Hu
Applications: BA
BMI-1 Antibody
[DyLight 594]
NB110-40823DL594
BMI-1 Antibody [DyLight 594]
Species: Hu, Mu, Rt, Bv, Ch, Fe, Pm, Rb, Ze
Applications: WB, ICC/IF, IHC

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Product General Protocols

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Video Protocols

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ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol BMI1