B-Raf Antibody

B-Raf, also know as c-Rmil, is a Serine/Threonine protein kinase member of the Raf family which includes Raf-1 and A-Raf. B-Raf is involved in the transduction of mitogenic signals from the cell membrane to the nucleus (1). Composed of three conserved region (CR1, CR2, CR3) B-Raf is expressed primarily in the brain and in the nervous system (2). It has been observed that MAPK is activated by B-Raf in response to nerve growth factor (3). More than 60% of malignant melanomas were found to contain a specific mutation, B-Raf (V599E) the product of which possesses constitutive kinase activity (4). Mutations in B-Raf have also been identified in lung cancer and non-Hodgkin lymphoma.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publication 1 - 1 of 1.

Publication using NBP1-89942	Applications	Species
Beltran-Sastre V, Benisty H, Burnier J et al. Tuneable endogenous mammalian target complementation via multiplexed plasmid-based recombineering. Sci Rep 2015-11-27 [PMID: 26612112] (WB, Human)	WB	Human

Array NBP1-89942

• B-Raf Antibodies
• B-Raf ELISA Kit
• B-Raf Lysate
• B-Raf Proteins