The protein encoded by SNF5 is a component of the chromatin-remodeling protein complex responsible for relieving repressive chromatin structures by allowing the transcriptional machinery to access targets more effectively. SNF5 has been found to be a tumor suppressor, and mutations within it are associated with some malignant tumors. Two transcript variants encoding different isoforms exist. Scurr’s group published interesting findings on effector proteins in senescence in Cell1. There, they immunoblotted with the SNF5 antibody to monitor B-Raf and IGFBP7 protein expression levels in several melanoma cell lines, and found that lentiviral-silencing of secreted IGFBP7 does not affect senescence in melanocytes and fibroblasts.
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Western Blot: SNF5 Antibody
Young’s HHMI group at MIT use of the SNF5 antibody in their RNAi studies helped them document the cell type-specific chromatin regulation of p19Arf as a key determinant of downstream oncogenic K-ras-mediated transformation and tissue responsiveness2. This variation explains the differential capacity of various cell types to execute tumor suppressor programs.
Novus Biologicals offers SNF5 reagents for your research needs including:
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