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Tumor

Hypoxia-Dependent CAR Stabilizing Construct in T cells Improves Solid Tumor Targeting and Efficacy

Banner image showing a chimeric antigen receptor (CAR) T cell.

By Victoria Osinski, PhD

Tags: 
Cancer
Chimeric Antigen Receptor
CAR-T
Hypoxia
immunology
Immunotherapy
Oxygen
T Cells
Tumor
Tumor Microenvironment
EGFR
ErbB2/Her2
ErbB3/Her3
ErbB4/Her4
HIF-1 alpha
Victoria Osinski

Tired T cells: Hypoxia Drives T cell Exhaustion in the Tumor Microenvironment

Banner image showing cancer cells in hypoxic conditions.

By Hunter Martinez

Tags: 
Adaptive Immunity
Hypoxia
immunology
metabolism
Mitochondria
Oxygen
ROS
T Cells
T cell exhaustion
T cell receptor
Tumor Microenvironment
BLIMP1/PRDM1
CD8
HIF-1 alpha
IFN-gamma
LAG-3
NFAT
NGFI-B alpha/Nur77/NR4A1
PD-1
PGC1 alpha
TIGIT
TNF-alpha
Hunter Martinez

Synthetic Biotic Medicine as Immunotherapy Against Cancer: Evidence From Arginine-Producing Engineered Bacteria

3D banner image showing example of pathogenic bacteria.

By Jamshed Arslan, Pharm D, PhD

Tags: 
Bacteria
Cancer
Cancer Research
Checkpoint Blockade
Checkpoint Inhibitors
immunology
Immuno-oncology
Immunotherapy
Innate Immunity
L-arginine
T Cells
Tumor
ARG-2
CD4
CD8
PD-1
PD-L1
Jamshed Arslan

Harnessing Natural Killer Cell Activity for Anti-Tumor Immunotherapy

Banner image showing the workflow for Natural Killer (NK) cells.

By Victoria Osinski, PhD

Tags: 
Natural Killer Cell
NK Cell
Cancer
immunology
Immuno-oncology
Immunotherapy
CD8
MHC Class I
NKG2A/CD159a/KLRC1
NKG2C/CD159c/KLRC2
NKG2D/CD314
NKG2E/KLRC3
KLRC4
NKG2H
DAP12
Killer Cell Immunoglobulin-like Receptor
CD7
CD19
Siglec-3/CD33
MUC1
ErbB2/Her2
MICA
MICB
ULBP
HDAC
HLA G
KIR2DL4/CD158d
Victoria Osinski

Using CometChip to Characterize Extracellular Regulators of DNA Repair: Does CD73 Levels in Cancer Cells Affect DNA Repair by Regulating Levels of Intracellular NAD+?

3D rendering of CometChip as a banner image.

By Natalia Gurule, PhD

 

Tags: 
Base Excision Repair
Cancer
CometAssay
CometChip
DNA Damage
DNA Repair
Metabolic Signaling
Tumor Microenvironment
TME
5’Nucleotidase/CD73
CD73
Nicotinamide Adenine Dinucleotide
NAD
PARP
Natalia Gurule

Deficiency of GluT1 leads to neurological problems while excess is involved in cancers

Immunohistochemical staining of formalin fixed paraffin embedded tissue of human placenta with rabbit polyclonal Glut1 antibody and staining developed using HRP-DAB with hematoxylin counterstaining.

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Glucose
GLUT1
galactose
epilepsy
GluT1-deficiency syndrome (GDS)
SLC2A1
Cancer
tubulin 4
glioblastoma
ChREBP
GluT2
Hepatocellular Carcinoma
Jamshed Arslan

Best Methods to Induce and Inhibit Autophagy Pharmacologically

VPS35 expression in endosomes and lysosomes of human U-2 OS cells, ICC

By Christina Towers, PhD

Tags: 
Autophagy
autophagosome
LC3
LC3B
Bafilomycin
Chloroquine
Lysosome
Western blot
Beclin 1
VPS34
ULK1
ATG4B
mTOR
autophagy induction
autophagy inhibition
Christina Towers
Cancer
rapamycin
Autophagic flux

mTOR Signaling and the Tumor Microenvironment

mTOR signaling pathway poster

By Yoskaly Lazo-Fernandez, PhD

Tags: 
TOR/mTOR
mTORC1
mTORC2
mTOR
TME
PI3K
HIF-1 alpha
S6K1
Akt
PKC
SGK3
FoxO1/3
CD4
CD8
HIF-1
VEGF
HIF-1 beta

Negative feedback regulation of EPAS1 gene in non-small cell lung cancer through DNA methyltransferases

HIF-1 alpha expression in human lung tissue, IHC

By Jamshed Arslan Pharm.D.

Tags: 
Cancer
Epigenetics
Hypoxia
HIF-1 alpha
HIF-2 alpha
HIF-1 beta
EPAS1
ChIP
DNMT1
DNMT3a
Dnmt3b
Non-Small Cell Lung Cancer

Bad news for stomach cancer: BAMBI protein inhibits gastric carcinoma via TGF-beta/epithelial-mesenchymal transition signaling

Collagen-I expression in rat colon tissue IHC

By Jamshed Arslan Pharm.D.

Tags: 
Epigenetics
Cancer
Tumor
Hypoxia
TGF-beta
HIF-1 alpha
Bambi
SOX4
VIM
MMP9
Ki67
IPO-38
N-cadherin
Collagen-1
Snai1
Acta2
Twist1
Fibronectin
EMT

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