B-Raf Products

Description

B-Raf, also know as c-Rmil, is a Serine/Threonine protein kinase member of the Raf family which includes Raf-1 and A-Raf. B-Raf is involved in the transduction of mitogenic signals from the cell membrane to the nucleus (1). Composed of three conserved region (CR1, CR2, CR3) B-Raf is expressed primarily in the brain and in the nervous system (2). It has been observed that MAPK is activated by B-Raf in response to nerve growth factor (3). More than 60% of malignant melanomas were found to contain a specific mutation, B-Raf (V599E) the product of which possesses constitutive kinase activity (4). Mutations in B-Raf have also been identified in lung cancer and non-Hodgkin lymphoma.

Bioinformatics

Entrez	109880 Mouse 114486 Rat 453 Human 673 Human
Uniprot	NM_004333 Human NP_004324 Human P15056 Human
Product By Gene ID	673
Alternate Names	94 kDa B-raf protein B-Raf proto-oncogene serine/threonine-protein kinase (p94) B-RAF1 BRAF1MGC126806 EC 2.7.11.1 MGC138284 murine sarcoma viral (v-raf) oncogene homolog B1 NS7 p94 Proto-oncogene B-Raf RAFB1 serine/threonine-protein kinase B-raf v-raf murine sarcoma viral oncogene homolog B1FLJ95109

Research Areas for B-Raf

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Phospho-Specific

Related B-Raf Blog Posts

Check out the latest blog posts on B-Raf.

You can't be without me - SNF5 The protein encoded by SNF5 is a component of the chromatin-remodeling protein complex responsible for relieving repressive chromatin structures by allowing the transcriptional machinery to access targets more effectively. SNF5 has been found to be a ...    Read more.

Autophagy and RAS signaling: Clinical implications By Christina Towers, PhD The cellular recycling process known as autophagy is currently being targeted in over 60 clinical trials focused on treating different types of cancer1. To date, the only autophagy-targeted ...    Read more.

MAPK3/ERK1 - A signal transduction pathway with roles in development and disease Mitogen-activated protein kinases (MAPKs) are important signaling proteins needed to transmit and relay extracellular stimuli and to illicit intracellular responses (1). The MAPK family of proteins are serine/threonine kinases that are able to phos...    Read more.

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