APEX2 Antibody

Apurinic/apyrimidinic (AP) sites occur frequently in DNA by spontaneous hydrolysis, DNA damaging agents or DNA glycosylases that remove specific abnormal bases. ClassII AP endonucleases act to repair this damage by cleaving the phosphodiester backbone. It is primarily located in the nucleus but is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 applications: Chemotaxis, WB.

Showing Publication 1 - 1 of 1.

Publication using NB100-56625	Applications	Species
Karkhanis V, Wang L, Tae S et al. Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase delta catalytic subunit gene, POLD1. J Biol Chem. 2012-08-24 [PMID: 22761421] (WB, Chemotaxis) Details: APEXL2(IMG-466). ChIP: NIH 3T3 cells (Figs 3,5). WB: 3T3-GFP lentiviral infected. knockdown using shRNA (Fig 7). Antibody specificity validated through ChIP assay and western blot knockdown.	WB, Chemotaxis

Array NB100-56625

• APEX2 Antibodies
• APEX2 Lysate
• APEX2 Protein