MYH Antibody (4D10)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using H00004595-M01	Applications	Species
Shangming Tang, Ema Stokasimov, Yuxiang Cui, David Pellman Breakage of cytoplasmic chromosomes by pathological DNA base excision repair Nature 2023-11-27 [PMID: 35477155]
Eshtad S, Mavajian Z, Rudd SG et al. hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Oncogenesis 2016-12-05 [PMID: 27918552]
Shinmura K, Kato H, Kawanishi Y et al. Reduced expression of the DNA glycosylase gene MUTYH is associated with an increased number of somatic mutations via a reduction in the DNA repair capacity in prostate adenocarcinoma. Mol Carcinog 2016-06-02 [PMID: 27253753]
Komine K, Shimodaira H, Takao M et al. Functional Complementation Assay for 47 MUTYH Variants in a MutY-Disrupted Escherichia coli strain. Hum Mutat. 2015-03-27 [PMID: 25820570]
Agustina L, Hahm SH, Han SH et al. Visualization of the physical and functional interaction between hMYH and hRad9 by Dronpa bimolecular fluorescence complementation. BMC Mol Biol. 2014-08-15 [PMID: 25127721]
Shinmura K, Goto M, Tao H et al. Impaired 8-Hydroxyguanine Repair Activity of MUTYH Variant p.Arg109Trp Found in a Japanese Patient with Early-Onset Colorectal Cancer. Oxid Med Cell Longev. 2014-03-23 [PMID: 24799981]
Hahm SH, Chung JH, Agustina L et al Human MutY homolog induces apoptosis in EPE-treated HEK293 cells Oncol Lett 2012-12-01 [PMID: 23226797]
Raetz AG, Xie Y, Kundu S et al. Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells. Carcinogenesis. 2012-09-20 [PMID: 22926731]
Shinmura K, Goto M, Suzuki M et al. Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer. The Journal of Pathology. 2011-11-01 [PMID: 21826668]
Suzuki T, Harashima H, Kamiya H. Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine. DNA Repair (Amst). 2010-02-28 [PMID: 20197241]
van der Post RS, Kets CM, Ligtenberg MJ et al. Immunohistochemistry is not an accurate first step towards the molecular diagnosis of MUTYH-associated polyposis. Virchows Arch. 2009-01-01 [PMID: 19031083]
Show All 11 Publications. Collapse Publications.

Array H00004595-M01

• MYH Antibodies
• MYH ELISA Kits
• MYH Lysates
• MYH Proteins