| Zhang, K;Eldin, P;Ciesla, JH;Briant, L;Lentini, JM;Ramos, J;Cobb, J;Munger, J;Fu, D; Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease eLife 2024-05-30 [PMID: 38814682] (Western Blot, Human) |
Western Blot |
Human |
| Coria, LM;Rodriguez, JM;Demaria, A;Bruno, LA;Medrano, MR;Castro, CP;Castro, EF;Del Priore, SA;Hernando Insua, AC;Kaufmann, IG;Saposnik, LM;Stone, WB;Prado, L;Notaro, US;Amweg, AN;Diaz, PU;Avaro, M;Ortega, H;Ceballos, A;Krum, V;Zurvarra, FM;Sidabra, JE;Drehe, I;Baqué, JA;Li Causi, M;De Nichilo, AV;Payes, CJ;Southard, T;Vega, JC;Auguste, AJ;Álvarez, DE;Flo, JM;Pasquevich, KA;Cassataro, J; A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection Nature communications 2024-02-02 [PMID: 38307851] (ELISA Capture, Human) |
ELISA Capture |
Human |
| Puray-Chavez, M;LaPak, KM;Jasuja, R;Pan, J;Xu, J;Eschbach, JE;Mohammed, S;Lawson, DQ;Wang, Q;Brody, SL;Major, MB;Goldfarb, D;Kutluay, SB; A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models bioRxiv : the preprint server for biology 2024-01-08 [PMID: 38260460] (Western Blot, Human) |
Western Blot |
Human |
| Hou, J;Wei, Y;Zou, J;Jaffery, R;Sun, L;Liang, S;Zheng, N;Guerrero, AM;Egan, NA;Bohat, R;Chen, S;Zheng, C;Mao, X;Yi, SS;Chen, K;McGrail, DJ;Sahni, N;Shi, PY;Chen, Y;Xie, X;Peng, W; Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection Nature communications 2024-01-02 [PMID: 38168026] (Western Blot, Human) |
Western Blot |
Human |
| Khan, I;Li, S;Tao, L;Wang, C;Ye, B;Li, H;Liu, X;Ahmad, I;Su, W;Zhong, G;Wen, Z;Wang, J;Hua, RH;Ma, A;Liang, J;Wan, XP;Bu, ZG;Zheng, YH; Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1 Nature communications 2024-01-02 [PMID: 38167417] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| Loi, LK;Yang, CC;Lin, YC;Su, YF;Juan, YC;Chen, YH;Chang, HC; Decoy peptides effectively inhibit the binding of SARS-CoV-2 to ACE2 on oral epithelial cells Heliyon 2023-12-01 [PMID: 38107325] (ICC, Human) |
ICC |
Human |
| Hashimi, M;Sebrell, TA;Hedges, JF;Snyder, D;Lyon, KN;Byrum, SD;Mackintosh, SG;Crowley, D;Cherne, MD;Skwarchuk, D;Robison, A;Sidar, B;Kunze, A;Loveday, EK;Taylor, MP;Chang, CB;Wilking, JN;Walk, ST;Schountz, T;Jutila, MA;Bimczok, D; Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection Nature communications 2023-10-28 [PMID: 37898615] (IHC, Mouse) |
IHC |
Mouse |
| Burke, B;Rocha, SM;Zhan, S;Eckley, M;Reasoner, C;Addetia, A;Lewis, J;Fagre, A;Charley, PA;Richt, JA;Weiss, SR;Tjalkens, RB;Veesler, D;Aboellail, T;Schountz, T; Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2 PLoS pathogens 2023-10-01 [PMID: 37856551] (Immunohistochemistry, Bat) |
Immunohistochemistry |
Bat |
| Mhlekude, B;Postmus, D;Stenzel, S;Weiner, J;Jansen, J;Zapatero-Belinchón, FJ;Olmer, R;Richter, A;Heinze, J;Heinemann, N;Mühlemann, B;Schroeder, S;Jones, TC;Müller, MA;Drosten, C;Pich, A;Thiel, V;Martin, U;Niemeyer, D;Gerold, G;Beule, D;Goffinet, C; Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection PLoS pathogens 2023-09-25 [PMID: 37747932] (Western Blot, Human) |
Western Blot |
Human |
| Sauve F, Nampoothiri S, Clarke SA et al. Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death EBioMedicine 2023-09-13 [PMID: 37713808] |
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| Sauve F, Nampoothiri S, Clarke SA et al. Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death EBioMedicine 9/13/2023 [PMID: 37713808] |
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| Yongmei Liu, Danying Chen, Yuanyuan Wang, Xinglin Li, Yaruo Qiu, Mei Zheng et al. Characterization of CCoV-HuPn-2018 spike protein-mediated viral entry J Virol 9/28/2023 [PMID: 37676001] |
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| Warren M. Meyers, Ryan J. Hong, Wun Chey Sin, Christine S. Kim, Kurt Haas A cell-based assay for rapid assessment of ACE2 catalytic function Scientific Reports 8/29/2023 [PMID: 37644110] |
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| Uppal S, Postnikova O, Villasmil R et al. Low-Density Lipoprotein Receptor (LDLR) Is Involved in Internalization of Lentiviral Particles Pseudotyped with SARS-CoV-2 Spike Protein in Ocular Cells International journal of molecular sciences 7/24/2023 [PMID: 37511618] |
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| Zhang, K;Eldin, P;Ciesla, JH;Briant, L;Lentini, JM;Ramos, J;Cobb, J;Munger, J;Fu, D; Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease bioRxiv : the preprint server for biology 2023-07-20 [PMID: 37502865] (Western Blot, Human) |
Western Blot |
Human |
| Robertson, SJ;Bedard, O;McNally, KL;Shaia, C;Clancy, CS;Lewis, M;Broeckel, RM;Chiramel, AI;Shannon, JG;Sturdevant, GL;Rosenke, R;Anzick, SL;Forte, E;Preuss, C;Baker, CN;Harder, JM;Brunton, C;Munger, S;Bruno, DP;Lack, JB;Leung, JM;Shamsaddini, A;Gardina, P;Sturdevant, DE;Sun, J;Martens, C;Holland, SM;Rosenthal, NA;Best, SM; Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19 Nature communications 2023-07-25 [PMID: 37491352] (IHC, Mouse) |
IHC |
Mouse |
| Wei, C;Datta, PK;Siegerist, F;Li, J;Yashwanth, S;Koh, KH;Kriho, NW;Ismail, A;Luo, S;Fischer, T;Amber, KT;Cimbaluk, D;Landay, A;Endlich, N;Rappaport, J;Michigan Medicine COVID−19 Investigators, ;Hayek, SS;Reiser, J; SuPAR mediates viral response proteinuria by rapidly changing podocyte function Nature communications 7/21/2023 [PMID: 37479685] |
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| Minami, S;Matsumoto, N;Omori, H;Nakamura, Y;Tamiya, S;Nouda, R;Nurdin, JA;Yamasaki, M;Kotaki, T;Kanai, Y;Okamoto, T;Tachibana, T;Ushijima, H;Kobayashi, T;Sato, S; Effective SARS-CoV-2 replication of monolayers of intestinal epithelial cells differentiated from human induced pluripotent stem cells Scientific reports 2023-07-18 [PMID: 37463955] (ICC, Human) |
ICC |
Human |
| Xu, D;Jiang, W;Wu, L;Gaudet, RG;Park, ES;Su, M;Cheppali, SK;Cheemarla, NR;Kumar, P;Uchil, PD;Grover, JR;Foxman, EF;Brown, CM;Stansfeld, PJ;Bewersdorf, J;Mothes, W;Karatekin, E;Wilen, CB;MacMicking, JD; PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection Nature 2023-07-12 [PMID: 37438530] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| Jim Baggen, Maarten Jacquemyn, Leentje Persoons, Els Vanstreels, Valerie E. Pye, Antoni G. Wrobel et al. TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry Cell 8/3/2023 [PMID: 37421949] |
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| McMahon CL, Castro J, Silvas J et al. Fetal brain vulnerability to SARS-CoV-2 infection Brain, behavior, and immunity 6/16/2023 [PMID: 37329995] |
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| Joaquin Lopez-Orozco, Nawell Fayad, Juveriya Qamar Qamar Khan, Alberto Felix-Lopez, Mohamed Elaish, Megha Rohamare et al. The RNA Interference Effector Protein Argonaute 2 Functions as a Restriction Factor Against SARS-CoV-2 Journal of Molecular Biology 8/15/2023 [PMID: 37271493] |
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| Barreto, EA;Cruz, AS;Veras, FP;Martins, R;Bernardelli, RS;Paiva, IM;Lima, TM;Singh, Y;Guimar�es, RC;Damasceno, S;Pereira, N;Alves, JM;Gon�alves, TT;Forato, J;Muraro, SP;Souza, GF;Batah, SS;Proenca-Modena, JL;Mori, MA;Cunha, FQ;Louzada-Junior, P;Cunha, TM;Nakaya, HI;Fabro, A;de Oliveira, RDR;Arruda, E;R�a, R;R�a Neto, �;Fernandes da Silva, MM;Leiria, LO; COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis Proceedings of the National Academy of Sciences of the United States of America 2023-05-23 [PMID: 37186819] (Neutralization, Human) |
Neutralization |
Human |
| Shunya Tsuji, Shohei Minami, Rina Hashimoto, Yusuke Konishi, Tatsuya Suzuki, Tamae Kondo et al. SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response Nature Aging 1/25/2022 [PMID: 37117754] |
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| Da-Yuan Chen, Jacquelyn Turcinovic, Shuchen Feng, Devin J. Kenney, Chue Vin Chin, Manish C. Choudhary et al. Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus iScience 5/19/2023 [PMID: 37095858] |
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| Stephanie Devignot, Tim Wai Sha, Thomas R Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi et al. Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA viruses Life Science Alliance 7/1/2023 [PMID: 37072184] |
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| Pinja Kettunen, Angelina Lesnikova, Noora Räsänen, Ravi Ojha, Leena Palmunen, Markku Laakso et al. SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase Journal of Virology 4/27/2023 [PMID: 37039676] |
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| Shu Y. Luo, Eman W. Moussa, Joaquin Lopez-Orozco, Alberto Felix-Lopez, Ray Ishida, Nawell Fayad et al. Identification of Human Host Substrates of the SARS-CoV-2 Mpro and PLpro Using Subtiligase N-Terminomics ACS Infectious Diseases 4/14/2023 [PMID: 37011043] |
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| Khan, JQ;Rohamare, M;Rajamanickam, K;Bhanumathy, KK;Lew, J;Kumar, A;Falzarano, D;Vizeacoumar, FJ;Wilson, JA; Generation of a SARS-CoV-2 Reverse Genetics System and Novel Human Lung Cell Lines That Exhibit High Virus-Induced Cytopathology Viruses 2023-05-30 [PMID: 37376581] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| McMahon CL, Castro J, Silvas J et al. Fetal brain vulnerability to SARS-CoV-2 infection Brain, behavior, and immunity 2023-06-16 [PMID: 37329995] |
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| Liu, K;Tang, M;Xu, W;Meng, X;Jin, H;Han, M;Pu, J;Li, Y;Jiao, F;Sun, R;Shen, R;Lui, KO;Lu, L;Zhou, B; An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo Proceedings of the National Academy of Sciences of the United States of America 2023-06-20 [PMID: 37307455] (Immunohistochemistry, Transgenic Mouse) |
Immunohistochemistry |
Transgenic Mouse |
| Kummarapurugu, AB;Hawkridge, AM;Ma, J;Osei, S;Martin, RK;Zheng, S;Voynow, JA; Neutrophil Elastase decreases SARS-CoV-2 Spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomian from the epithelial surface The Journal of biological chemistry 2023-05-13 [PMID: 37187291] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| Alvin Phan, Hugo Avila, J. Andrew MacKay Biomimetic SARS-CoV-2 Spike Protein Nanoparticles Biomacromolecules 5/8/2023 [PMID: 37001147] |
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| M Ulinici, A Sulji?, M Poggianell, R Milan Bono, K Resman Rus, A Paraschiv, AM Bonetti, M Todiras, A Corlateanu, S Groppa, E Ceban, M Petrovec, A Marcello Characterisation of the Antibody Response in Sinopharm (BBIBP-CorV) Recipients and COVID-19 Convalescent Sera from the Republic of Moldova Vaccines, 2023-03-13;11(3):. 2023-03-13 [PMID: 36992221] (FLOW, Human) |
FLOW |
Human |
| Shamim Mohammad, Yuxia Wang, John Cordero, Christopher Watson, Robert Molestina, Sujatha Rashid et al. Development and validation of a rapid and easy-to-perform point-of-care lateral flow immunoassay (LFIA) for the detection of SARS-CoV-2 spike protein Frontiers in Immunology 2/23/2023 [PMID: 36911726] |
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| Conor McQuaid, Alexander Solorzano, Ian Dickerson, Rashid Deane Uptake of severe acute respiratory syndrome coronavirus 2 spike protein mediated by angiotensin converting enzyme 2 and ganglioside in human cerebrovascular cells Frontiers in Neuroscience 2/16/2023 [PMID: 36875642] |
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| Yingzi Xiao, Ying Yan, Le Chang, Huimin Ji, Huizhen Sun, Shi Song et al. CDK4/6 inhibitor palbociclib promotes SARS-CoV-2 cell entry by down-regulating SKP2 dependent ACE2 degradation Antiviral Research 4/1/2023 [PMID: 36806814] |
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| AT Tang, DW Buchholz, KM Szigety, B Imbiakha, S Gao, M Frankfurte, M Wang, J Yang, P Hewins, P Mericko-Is, NA Leu, S Sterling, IA Monreal, J Sahler, A August, X Zhu, KA Jurado, M Xu, EE Morrisey, SE Millar, HC Aguilar, ML Kahn Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection PloS Biology, 2023-02-06;21(2):e3001989. 2023-02-06 [PMID: 36745682] (IHC, Western Blot, Mouse) |
IHC, Western Blot |
Mouse |
| Hidetaka Matsuda, Takuto Nosaka, Katsushi Hiramatsu, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji et al. Histology and cytokine levels in hepatic injury accompanying a case of non-severe COVID-19 Clinical Journal of Gastroenterology 4/1/2023 [PMID: 36690911] |
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| N Tailor, BM Warner, BD Griffin, K Tierney, E Moffat, K Frost, R Vendramell, A Leung, M Willman, SP Thomas, Y Pei, SA Booth, C Embury-Hya, SK Wootton, D Kobasa Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene Viruses, 2022-12-28;15(1):. 2022-12-28 [PMID: 36680125] (Western Blot, Human) |
Western Blot |
Human |
| Y Kato, K Nishiyama, J Man Lee, Y Ibuki, Y Imai, T Noda, N Kamiya, T Kusakabe, Y Kanda, M Nishida TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation International Journal of Molecular Sciences, 2022-12-21;24(1):. 2022-12-21 [PMID: 36613540] (Western Blot, Mouse) |
Western Blot |
Mouse |
| Elena Garreta, Daniel Moya-Rull, Megan L. Stanifer, Vanessa Monteil, Patricia Prado, Andrés Marco et al. Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells STAR Protocols 12/16/2022 [PMID: 36595951] |
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| A Miluzio, A Cuomo, C Cordiglier, L Donnici, E Pesce, M Bombaci, M Conti, A Fasciani, L Terraccian, L Manganaro, M Toccafondi, A Scagliola, S Oliveto, S Ricciardi, R Grifantini, R De Frances, S Abrignani, N Manfrini, S Biffo Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2 EBioMedicine, 2022-12-28;87(0):104390. 2022-12-28 [PMID: 36584595] (Co-Immunoprecipitation, Flow Cytometry, IHC, Western Blot, Human) |
Co-Immunoprecipitation, Flow Cytometry, IHC, Western Blot |
Human |
| X Guo, J Cao, JP Cai, J Wu, J Huang, P Asthana, SKK Wong, ZW Ye, S Gurung, Y Zhang, S Wang, Z Wang, X Ge, HY Kwan, A Lyu, KM Chan, N Wong, J Huang, Z Zhou, ZX Bian, S Yuan, HLX Wong Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2 Nature Communications, 2022-12-23;13(1):7907. 2022-12-23 [PMID: 36564389] (ICC, Human) |
ICC |
Human |
| Juan Shi, Gang Wang, Jian Zheng, Abhishek K. Verma, Xiaoqing Guan, Moffat M. Malisheni et al. Effective vaccination strategy using SARS-CoV-2 spike cocktail against Omicron and other variants of concern npj Vaccines 12/19/2022 [PMID: 36535987] |
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| Balasubramanian N, James TD, Selvakumar GP et al. Repeated ethanol exposure and withdrawal alters angiotensin-converting enzyme 2 expression in discrete brain regions: Implications for SARS-CoV-2 neuroinvasion Alcoholism: Clinical and Experimental Research 2023-02-01 [PMID: 36529893] |
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| Balasubramanian N, James TD, Selvakumar GP et al. Repeated ethanol exposure and withdrawal alters angiotensin-converting enzyme 2 expression in discrete brain regions: Implications for SARS-CoV-2 neuroinvasion Alcoholism: Clinical and Experimental Research 2/1/2023 [PMID: 36529893] |
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| DR Adney, J Lovaglio, JE Schulz, CK Yinda, VA Avanzato, E Haddock, JR Port, MG Holbrook, PW Hanley, G Saturday, D Scott, C Shaia, AM Nelson, JR Spengler, C Tansey, CM Cossaboom, NM Wendling, C Martens, J Easley, SW Yap, SN Seifert, VJ Munster Severe acute respiratory disease in American mink experimentally infected with SARS-CoV-2 JCI Insight, 2022-11-22;7(22):. 2022-11-22 [PMID: 36509288] (IHC, Mink) |
IHC |
Mink |
| SB Biering, FT Gomes de S, LV Tjang, F Pahmeier, C Zhu, R Ruan, SF Blanc, TS Patel, CM Worthingto, DR Glasner, B Castillo-R, V Servellita, NTN Lo, MP Wong, CM Warnes, DR Sandoval, TM Clausen, YA Santos, DM Fox, V Ortega, AM Näär, RS Baric, SA Stanley, HC Aguilar, JD Esko, CY Chiu, JE Pak, PR Beatty, E Harris SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-beta signaling Nature Communications, 2022-12-09;13(1):7630. 2022-12-09 [PMID: 36494335] (Western Blot, Human) |
Western Blot |
Human |
| H Guo, A Li, TY Dong, J Su, YL Yao, Y Zhu, ZL Shi, M Letko ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells MBio, 2022-11-21;0(0):e0256622. 2022-11-21 [PMID: 36409074] (Neutralization, Bat, Human) |
Neutralization |
Bat, Human |
| Anna Onnis, Emanuele Andreano, Chiara Cassioli, Francesca Finetti, Chiara Della Bella, Oskar Staufer et al. SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly Journal of Experimental Medicine 2/6/2023 [PMID: 36378226] |
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| Christin Mache, Jessica Schulze, Gudrun Holland, Daniel Bourquain, Jean-Marc Gensch, Djin-Ye Oh et al. SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell model Communications Biology 10/27/2022 [PMID: 36302956] |
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| JV Harte, SL Wakerlin, AJ Lindsay, JV McCarthy, C Coleman-Va Metalloprotease-Dependent S2'-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2 Viruses, 2022-09-21;14(10):. 2022-09-21 [PMID: 36298651] |
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| Beckman D, Bonillas A, Diniz GB et al. SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19 Cell reports 11/1/2022 [PMID: 36288725] |
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| Jalloh S, Olejnik J, Berrigan J et al. CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses PLOS Pathogens 2022-10-24 [PMID: 36279285] |
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| Jalloh S, Olejnik J, Berrigan J et al. CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses PLOS Pathogens 10/24/2022 [PMID: 36279285] |
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| Haoyu Sun, Yong Du, Rinki Kumar, Nicholas Buchkovich, Pingnian He Increased circulating microparticles contribute to severe infection and adverse outcomes of COVID-19 in patients with diabetes American Journal of Physiology-Heart and Circulatory Physiology 12/1/2022 [PMID: 36269646] |
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| J Song, RD Chow, M Pena-Herna, L Zhang, SA Loeb, EY So, OD Liang, P Ren, S Chen, CB Wilen, S Lee LRRC15 inhibits SARS-CoV-2 cellular entry in trans PloS Biology, 2022-10-13;20(10):e3001805. 2022-10-13 [PMID: 36228039] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| K Shilagardi, ED Spear, R Abraham, DE Griffin, S Michaelis The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation MBio, 2022-10-05;0(0):e0254322. 2022-10-05 [PMID: 36197088] (Western Blot, Human) |
Western Blot |
Human |
| TD Saccon, F Mousovich-, RG Ludwig, VC Carregari, AB Dos Anjos, ASC Dos Passos, MC Martini, PP Barbosa, GF de Souza, SP Muraro, J Forato, MR Amorim, RE Marques, FP Veras, E Barreto, TT Gonçalves, IM Paiva, NPB Fazolini, CMK Onodera, RB Martins Ju, PHC de Araújo, SS Batah, RMM Viana, DM de Melo, AT Fabro, E Arruda, F Queiroz Cu, TM Cunha, MAM Pretti, BJ Smith, H Marques-So, TL Knittel, GP Ruiz, GS Profeta, TCM Fontes-Cal, M Boroni, MAR Vinolo, AS Farias, PMM Moraes-Vie, JMA Bizzacchi, T Teesalu, FDM Chaim, E Cazzo, EA Chaim, JL Proença-Mó, D Martins-de, MK Osako, LO Leiria, MA Mori SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner Nature Communications, 2022-09-29;13(1):5722. 2022-09-29 [PMID: 36175400] (ICC, African Green Monkey) |
ICC |
African Green Monkey |
| N Brasu, I Elia, V Russo, G Montacchie, SA Stabile, C De Intinis, F Fesi, K Gizzi, M Macagno, M Montone, B Mussolin, A Grifoni, S Faravelli, S Marchese, F Forneris, R De Frances, A Sette, V Barnaba, A Sottile, A Sapino, L Pace Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination Nature Immunology, 2022-09-22;0(0):. 2022-09-22 [PMID: 36138186] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| Emiel Vanhulle, Thomas D’huys, Becky Provinciael, Joren Stroobants, Anita Camps, Sam Noppen et al. Carbohydrate-binding protein from stinging nettle as fusion inhibitor for SARS-CoV-2 variants of concern Frontiers in Cellular and Infection Microbiology 8/30/2022 [PMID: 36111239] |
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| M Montano, AR Victor, DK Griffin, T Duong, N Bolduc, A Farmer, V Garg, AK Hadjantona, A Coates, FL Barnes, CG Zouves, WC Greene, M Viotti SARS-CoV-2 can infect human embryos Scientific Reports, 2022-09-14;12(1):15451. 2022-09-14 [PMID: 36104397] (Control, ICC, Human) |
Control, ICC |
Human |
| Y Yao, K Subedi, T Liu, N Khalasawi, CD Pretto-Ker, JW Wotring, J Wang, C Yin, A Jiang, C Fu, P Dimitrion, J Li, J Veenstra, Q Yi, K McKinnon, JE McKinnon, JZ Sexton, L Zhou, QS Mi Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes Cell Discovery, 2022-09-09;8(1):89. 2022-09-09 [PMID: 36085197] (Western Blot, Human) |
Western Blot |
Human |
| J Hou, Y Wei, J Zou, R Jaffery, S Liang, C Zheng, K Chen, PY Shi, Y Chen, X Xie, W Peng Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infection Research square, 2022-08-15;0(0):. 2022-08-15 [PMID: 36032971] (Western Blot, Human) |
Western Blot |
Human |
| Diego Cantoni, Matthew J Murray, Mphatso D Kalemera, Samuel J Dicken, Lenka Stejskal, Georgina Brown et al. Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike EMBO reports 10/6/2022 [PMID: 35999696] |
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| J.J. Patten, Patrick T. Keiser, Deisy Morselli-Gysi, Giulia Menichetti, Hiroyuki Mori, Callie J. Donahue et al. Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization iScience 9/16/2022 [PMID: 35992305] |
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| Julia Kazmierski, Kirstin Friedmann, Dylan Postmus, Jackson Emanuel, Cornelius Fischer, Jenny Jansen et al. Nonproductive exposure of PBMCs to SARS‐CoV ‐2 induces cell‐intrinsic innate immune responses Molecular Systems Biology 8/1/2022 [PMID: 35975552] |
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| B Meng, R Datir, J Choi, CITIID-NIH, JR Bradley, KGC Smith, JH Lee, RK Gupta SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity Cell Reports, 2022-08-03;40(7):111220. 2022-08-03 [PMID: 35963244] (Neutralization, Human) |
Neutralization |
Human |
| P Su, D Zhai, AHC Wong, F Liu Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice Molecular Brain, 2022-08-09;15(1):71. 2022-08-09 [PMID: 35945596] (Co-Immunoprecipitation, IHC, Western Blot, Human, Mouse) |
Co-Immunoprecipitation, IHC, Western Blot |
Human, Mouse |
| Y Zhu, KY Chew, M Wu, AC Karawita, G McCallum, LE Steele, A Yamamoto, LI Labzin, T Yarlagadda, AA Khromykh, X Wang, JDJ Sng, CJ Stocks, Y Xia, TR Kollmann, D Martino, M Joensuu, FA Meunier, G Balistreri, H Bielefeldt, AC Bowen, A Kicic, PD Sly, KM Spann, KR Short Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells PloS Biology, 2022-08-01;20(8):e3001728. 2022-08-01 [PMID: 35913989] (ICC, Western Blot, Human) |
ICC, Western Blot |
Human |
| CW Chang, KM Parsi, M Somasundar, E Vanderleed, P Liu, J Cruz, A Cousineau, RW Finberg, EA Kurt-Jones A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron Variants Viruses, 2022-06-23;14(7):. 2022-06-23 [PMID: 35891350] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| Chanawee Hirunpattarasilp, Greg James, Jaturon Kwanthongdee, Felipe Freitas, Jiandong Huo, Huma Sethi et al. SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction Brain 2/13/2023 [PMID: 35867861] |
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| Jaspreet Osan, Sattya N. Talukdar, Friederike Feldmann, Beth Ann DeMontigny, Kailey Jerome, Kristina L. Bailey et al. Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary Disease Microbiology Spectrum 8/31/2022 [PMID: 35862971] |
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| Sophie-Marie Aicher, Felix Streicher, Maxime Chazal, Delphine Planas, Dongsheng Luo, Julian Buchrieser et al. Species-Specific Molecular Barriers to SARS-CoV-2 Replication in Bat Cells Journal of Virology 7/27/2022 [PMID: 35862713] |
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| H Stölting, L Baillon, R Frise, K Bonner, RJ Hewitt, PL Molyneaux, ML Gore, Breathing, WS Barclay, S Saglani, CM Lloyd Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1 Mucosal Immunology, 2022-07-15;0(0):. 2022-07-15 [PMID: 35840680] (IHC, Human) |
IHC |
Human |
| Henry Daniell, Smruti K. Nair, Yao Shi, Ping Wang, Kathleen T. Montone, Pamela A. Shaw et al. Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatment Molecular Therapy - Methods & Clinical Development 9/8/2022 [PMID: 35818571] |
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| Marie O. Pohl, Laura Martin-Sancho, Ranjala Ratnayake, Kris M. White, Laura Riva, Qi-Yin Chen et al. Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity ACS Infectious Diseases 7/8/2022 [PMID: 35766385] |
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| George Ssenyange, Maya Kerfoot, Min Zhao, Shelli Farhadian, Sidi Chen, Lei Peng et al. Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2 Cell Reports Methods 7/18/2022 [PMID: 35757815] |
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| Andrea Favalli, Ennio Giulio Favalli, Andrea Gobbini, Elena Zagato, Mauro Bombaci, Gabriella Maioli et al. Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations Frontiers in Immunology 6/10/2022 [PMID: 35757699] |
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| Shilei Ding, Irfan Ullah, Shang Yu Gong, Jonathan R. Grover, Mohammadjavad Mohammadi, Yaozong Chen et al. VE607 stabilizes SARS-CoV-2 Spike in the “RBD-up” conformation and inhibits viral entry iScience 7/15/2022 [PMID: 35677392] |
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| Zhang Y, Archie SR, Ghanwatkar Y et al. Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping Fluids and Barriers of the CNS 6/7/2022 [PMID: 35672716] |
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| Zhang Y, Archie SR, Ghanwatkar Y et al. Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping Fluids and Barriers of the CNS 2022-06-07 [PMID: 35672716] |
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| Eriksen A, Moller R, Markovoz B et al. Protocols for SARS-CoV-2 infection in primary ocular cells and eye organoids STAR Protocols 4/1/2022 [PMID: 35664254] |
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| Mélia Magnen, Ran You, Arjun A. Rao, Ryan T. Davis, Lauren Rodriguez, Camille R. Simoneau et al. Immediate myeloid depot for SARS-CoV-2 in the human lung Research Square 4/26/2023 [PMID: 35611333] |
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| Emiel Vanhulle, Joren Stroobants, Becky Provinciael, Anita Camps, Sam Noppen, Piet Maes et al. SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening Antiviral Research 7/1/2022 [PMID: 35595082] |
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| Mélia Magnen, Ran You, Arjun A. Rao, Ryan T. Davis, Lauren Rodriguez, Camille R. Simoneau et al. Immediate myeloid depot for SARS-CoV-2 in the human lung bioRxiv 1/11/2023 [PMID: 35592107] |
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| Sze Keong Tey, Hoiyan Lam, Samuel Wan Ki Wong, Hanjun Zhao, Kelvin Kai‐Wang To, Judy Wai Ping Yam ACE2‐enriched extracellular vesicles enhance infectivity of live SARS‐CoV‐2 virus Journal of Extracellular Vesicles 5/18/2022 [PMID: 35582880] |
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| Garreta E, Prado P, Stanifer ML et al. A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells Cell Metabolism 2022-06-07 [PMID: 35561674] |
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| Garreta E, Prado P, Stanifer ML et al. A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells Cell Metabolism 2022-06-07 [PMID: 35561674] |
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| Garreta E, Prado P, Stanifer ML et al. A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells Cell Metabolism 2022-06-07 [PMID: 35561674] |
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| Jonathan L. Torres, Gabriel Ozorowski, Emanuele Andreano, Hejun Liu, Jeffrey Copps, Giulia Piccini et al. Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody Proceedings of the National Academy of Sciences 5/17/2022 [PMID: 35549549] |
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| Georg Jocher, Vincent Grass, Sarah K Tschirner, Lydia Riepler, Stephan Breimann, Tuğberk Kaya et al. ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion EMBO reports 6/7/2022 [PMID: 35527514] |
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| Zaid Taha, Rozanne Arulanandam, Glib Maznyi, Elena Godbout, Madalina E. Carter-Timofte, Naziia Kurmasheva et al. Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen Molecular Therapy 9/1/2022 [PMID: 35526097] |
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| Titilola D. Kalejaiye, Rohan Bhattacharya, Morgan A. Burt, Tatianna Travieso, Arinze E. Okafor, Xingrui Mou et al. SARS-CoV-2 Employ BSG/CD147 and ACE2 Receptors to Directly Infect Human Induced Pluripotent Stem Cell-Derived Kidney Podocytes Frontiers in Cell and Developmental Biology 4/20/2022 [PMID: 35517495] |
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| Lucas R. Struble, Audrey L. Smith, William E. Lutz, Gabrielle Grubbs, Satish Sagar, Kenneth W. Bayles et al. Insect cell expression and purification of recombinant SARS‐COV‐2 spike proteins that demonstrate ACE2 binding Protein Science 5/1/2022 [PMID: 35481636] |
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| Oscar Francesconi, Lorena Donnici, Marco Fragai, Elisa Pesce, Mauro Bombaci, Alessandra Fasciani et al. Synthetic carbohydrate-binding agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2 iScience 5/20/2022 [PMID: 35434540] |
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| M Ramal-Sanc, C Castellini, C Cimini, A Taraschi, L Valbonetti, A Barbonetti, N Bernabò, B Barboni ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa International Journal of Molecular Sciences, 2022-03-28;23(7):. 2022-03-28 [PMID: 35409054] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| P Spitalieri, F Centofanti, M Murdocca, MG Scioli, A Latini, S Di Cesare, G Citro, A Rossi, A Orlandi, S Miersch, SS Sidhu, PP Pandolfi, A Botta, F Sangiuolo, G Novelli Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids Cells, 2022-04-05;11(7):. 2022-04-05 [PMID: 35406799] (IHC, Human) |
IHC |
Human |
| C Junqueira, Â Crespo, S Ranjbar, LB de Lacerda, M Lewandrows, J Ingber, B Parry, S Ravid, S Clark, MR Schrimpf, F Ho, C Beakes, J Margolin, N Russell, K Kays, J Boucau, U Das Adhika, SM Vora, V Leger, L Gehrke, L Henderson, E Janssen, D Kwon, C Sander, J Abraham, MB Goldberg, H Wu, G Mehta, S Bell, AE Goldfeld, MR Filbin, J Lieberman FcgammaR-mediated SARS-CoV-2 infection of monocytes activates inflammation Nature, 2022-04-06;0(0):. 2022-04-06 [PMID: 35385861] (Flow Cytometry, Neutralization, Human) |
Flow Cytometry, Neutralization |
Human |
| Sallieu Jalloh, Judith Olejnik, Jacob Berrigan, Annuurun Nisa, Ellen L Suder, Hisashi Akiyama et al. CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses bioRxiv 8/2/2023 [PMID: 35378756] |
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| Domizia Baldassi, Shubhankar Ambike, Martin Feuerherd, Cho-Chin Cheng, David J. Peeler, Daniel P. Feldmann et al. Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes Journal of Controlled Release 5/1/2022 [PMID: 35364120] |
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| Valerio Laghi, Veronica Rezelj, Laurent Boucontet, Maxence Frétaud, Bruno Da Costa, Pierre Boudinot et al. Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder Frontiers in Cellular and Infection Microbiology 3/11/2022 [PMID: 35360100] |
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| L Casciola-R, DR Thiemann, F Andrade, MI Trejo-Zamb, EK Leonard, JB Spangler, NE Skinner, J Bailey, S Yegnasubra, R Wang, AM Vaghasia, A Gupta, AL Cox, SC Ray, RM Linville, Z Guo, PC Searson, CE Machamer, S Desiderio, LM Sauer, O Laeyendeck, BT Garibaldi, L Gao, M Damarla, PM Hassoun, JE Hooper, CA Mecoli, L Christophe, L Gutierrez-, Q Yang, D Hines, WA Clarke, RE Rothman, A Pekosz, KZ Fenstermac, Z Wang, SL Zeger, A Rosen IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function JCI Insight, 2022-05-09;7(9):. 2022-05-09 [PMID: 35349483] (IHC, Human) |
IHC |
Human |
| Nicola Wanner, Geoffroy Andrieux, Pau Badia-i-Mompel, Carolin Edler, Susanne Pfefferle, Maja T. Lindenmeyer et al. Molecular consequences of SARS-CoV-2 liver tropism Nature Metabolism 3/28/2022 [PMID: 35347318] |
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| Yun-Qi Zhou, Ke Wang, Xue-Yan Wang, Hong-Yong Cui, Yongxiang Zhao, Ping Zhu et al. SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner Emerging Microbes & Infections 12/31/2022 [PMID: 35343395] |
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| Y Menuchin-L, A Schreiber, A Lecanda, A Mecate-Zam, L Brunotte, OE Psathaki, S Ludwig, T Rauen, HR Schöler SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids Stem Cell Reports, 2022-03-24;0(0):. 2022-03-24 [PMID: 35334213] (Neutralization, Human) |
Neutralization |
Human |
| Maik Friedrich, Gabriele Pfeifer, Stefanie Binder, Achim Aigner, Philippe Vollmer Barbosa, Gustavo R. Makert et al. Selection and Validation of siRNAs Preventing Uptake and Replication of SARS-CoV-2 Frontiers in Bioengineering and Biotechnology 3/2/2022 [PMID: 35309990] |
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| Xu-Rui Shen, Rong Geng, Qian Li, Ying Chen, Shu-Fen Li, Qi Wang et al. ACE2-independent infection of T lymphocytes by SARS-CoV-2 Signal Transduction and Targeted Therapy 3/11/2022 [PMID: 35277473] |
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| Savannah M. Rocha, Anna C. Fagre, Amanda S. Latham, Jason E. Cummings, Tawfik A. Aboellail, Philip Reigan et al. A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection Frontiers in Immunology 2/16/2022 [PMID: 35250984] |
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| Verena van der Heide, Sonia Jangra, Phillip Cohen, Raveen Rathnasinghe, Sadaf Aslam, Teresa Aydillo et al. Limited extent and consequences of pancreatic SARS-CoV-2 infection Cell Reports 3/1/2022 [PMID: 35247306] |
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| X Wang, J Luo, Z Wen, L Shuai, C Wang, G Zhong, X He, H Cao, R Liu, J Ge, R Hua, Z Sun, X Wang, J Wang, Z Bu Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung PloS Pathogens, 2022-02-17;18(2):e1010343. 2022-02-17 [PMID: 35176124] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| Waleed Rahmani, Hyunjae Chung, Sarthak Sinha, Maxwell P. Bui-Marinos, Rohit Arora, Arzina Jaffer et al. Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids iScience 2/18/2022 [PMID: 35106453] |
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| Lieve E.H. van der Donk, Julia Eder, John L. van Hamme, Philip J. M. Brouwer, Mitch Brinkkemper, Ad C. van Nuenen et al. SARS‐CoV‐2 infection activates dendritic cells via cytosolic receptors rather than extracellular TLRs European Journal of Immunology 4/1/2022 [PMID: 35099061] |
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| Elizabeth S. Taglauer, Elisha M. Wachman, Lillian Juttukonda, Timothy Klouda, Jiwon Kim, Qiong Wang et al. Acute Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy Is Associated with Placental Angiotensin-Converting Enzyme 2 Shedding The American Journal of Pathology 4/1/2023 [PMID: 35090860] |
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| S Krasemann, U Haferkamp, S Pfefferle, MS Woo, F Heinrich, M Schweizer, A Appelt-Men, A Cubukova, J Barenberg, J Leu, K Hartmann, E Thies, JL Littau, D Sepulveda-, L Zhang, K Ton, Y Liang, J Matschke, F Ricklefs, T Sauvigny, J Sperhake, A Fitzek, A Gerhartl, A Brachner, N Geiger, EM König, J Bodem, S Franzenbur, A Franke, S Moese, FJ Müller, G Geisslinge, C Claussen, A Kannt, A Zaliani, P Gribbon, B Ondruschka, W Neuhaus, MA Friese, M Glatzel, O Pless The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 Stem Cell Reports, 2022-01-20;0(0):. 2022-01-20 [PMID: 35063125] (Neutralization, Human) |
Neutralization |
Human |
| L El-Shennaw, AD Hoffmann, NK Dashzeveg, KM McAndrews, PJ Mehl, D Cornish, Z Yu, VL Tokars, V Nicolaescu, A Tomatsidou, C Mao, CJ Felicelli, CF Tsai, C Ostiguin, Y Jia, L Li, K Furlong, J Wysocki, X Luo, CF Ruivo, D Batlle, TJ Hope, Y Shen, YK Chae, H Zhang, VS LeBleu, T Shi, S Swaminatha, Y Luo, D Missiakas, GC Randall, AR Demonbreun, MG Ison, R Kalluri, D Fang, H Liu Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Nature Communications, 2022-01-20;13(1):405. 2022-01-20 [PMID: 35058437] (Western Blot, Human) |
Western Blot |
Human |
| Yosuke Shikama, Mie Kurosawa, Masae Furukawa, Yasusei Kudo, Naozumi Ishimaru, Kenji Matsushita The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa Inflammation 6/1/2022 [PMID: 35044570] |
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| J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, R Roverts, D Daviran, LAS Fermin, B Willemsen, M Beukenboom, S Djudjaj, S von Stillf, LE van Eijk, M Mastik, M Bulthuis, WD Dunnen, H van Goor, JL Hillebrand, SH Triana, T Alexandrov, MC Timm, BT van den Be, M van den Br, Q Nlandu, J Heijnert, EMJ Bindels, RM Hoogenboez, F Mooren, C Kuppe, P Miesen, K Grünberg, T Ijzermans, EJ Steenberge, J Czogalla, MF Schreuder, N Sommerdijk, A Akiva, P Boor, VG Puelles, J Floege, TB Huber, COVID Moon, RP van Rij, IG Costa, RK Schneider, B Smeets, R Kramann SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids Cell Stem Cell, 2021-12-25;29(2):217-231.e8. 12/25/2021 [PMID: 35032430] |
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| Jean‐Philippe Desilles, Mialitiana Solo Nomenjanahary, Arturo Consoli, Véronique Ollivier, Dorothée Faille, Marie‐Charlotte Bourrienne et al. Impact of COVID‐19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID‐19 patients with acute ischemic stroke Journal of Thrombosis and Haemostasis 12/21/2022 [PMID: 35032088] |
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| J Grau-Expós, D Perea, M Suppi, N Massana, A Vergara, MJ Soler, B Trinite, J Blanco, J García-Pér, J Alcamí, A Serrano-Mo, J Rosado, V Falcó, M Genescà, MJ Buzon Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells PloS Pathogens, 2022-01-13;18(1):e1010171. 2022-01-13 [PMID: 35025963] (ICC, IHC, Human) |
ICC, IHC |
Human |
| Qi Cui, Gustavo Garcia, Mingzi Zhang, Cheng Wang, Hongzhi Li, Tao Zhou et al. Compound screen identifies the small molecule Q34 as an inhibitor of SARS-CoV-2 infection iScience 1/21/2022 [PMID: 34977495] |
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| Li T, Yang Y, Li Y et al. Platelets mediate inflammatory monocyte activation by SARS-CoV-2 Spike protein The Journal of clinical investigation 12/29/2021 [PMID: 34964720] |
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| J Shi, X Jin, Y Ding, X Liu, A Shen, Y Wu, M Peng, C Shen Receptor-Binding Domain Proteins of SARS-CoV-2 Variants Elicited Robust Antibody Responses Cross-Reacting with Wild-Type and Mutant Viruses in Mice Vaccines, 2021-11-24;9(12):. 2021-11-24 [PMID: 34960131] (ELISA Detection, Human) |
ELISA Detection |
Human |
| Manon Ruffin, Jeanne Bigot, Claire Calmel, Julia Mercier, Maëlle Givelet, Justine Oliva et al. Flagellin From Pseudomonas aeruginosa Modulates SARS-CoV-2 Infectivity in Cystic Fibrosis Airway Epithelial Cells by Increasing TMPRSS2 Expression Frontiers in Immunology 12/7/2021 [PMID: 34950129] |
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| Julia Ettich, Julia Werner, Hendrik T. Weitz, Eva Mueller, Roland Schwarzer, Philipp A. Lang et al. A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans -Signaling and Cellular Infection with SARS-CoV-2 Journal of Virology 2/23/2022 [PMID: 34935434] |
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| SB Biering, FTG de Sousa, LV Tjang, F Pahmeier, R Ruan, SF Blanc, TS Patel, CM Worthingto, DR Glasner, B Castillo-R, V Servellita, NTN Lo, MP Wong, CM Warnes, DR Sandoval, TM Clausen, YA Santos, V Ortega, HC Aguilar, JD Esko, CY Chui, JE Pak, PR Beatty, E Harris SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-beta signaling bioRxiv : the preprint server for biology, 2021-12-13;0(0):. 2021-12-13 [PMID: 34931188] (Western Blot, Human) |
Western Blot |
Human |
| Meng-Li Wu, Feng-Liang Liu, Jing Sun, Xin Li, Xiao-Yan He, Hong-Yi Zheng et al. SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury Signal Transduction and Targeted Therapy 12/17/2021 [PMID: 34921131] |
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| J Wang, G Yang, X Wang, Z Wen, L Shuai, J Luo, C Wang, Z Sun, R Liu, J Ge, X He, R Hua, X Wang, X Yang, W Chen, G Zhong, Z Bu SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells Cell Discovery, 2021-12-14;7(1):119. 2021-12-14 [PMID: 34903715] (Flow Cytometry, Neutralization, Human, Primate - C. aethiops) |
Flow Cytometry, Neutralization |
Human, Primate - C. aethiops |
| Juliana Gonçalves, A. Margarida Juliano, Nádia Charepe, Marta Alenquer, Diogo Athayde, Filipe Ferreira et al. Secretory IgA and T cells targeting SARS-CoV-2 spike protein are transferred to the breastmilk upon mRNA vaccination Cell Reports Medicine 12/2/2021 [PMID: 34873588] |
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| Oghenemega Okoloko, Elizabeth R. Vanderwall, Lucille M. Rich, Maria P. White, Stephen R. Reeves, Whitney E. Harrington et al. Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells Frontiers in Pharmacology 11/19/2021 [PMID: 34867390] |
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| Jaewon Song, Ryan D. Chow, Mario Pena-Hernandez, Li Zhang, Skylar A. Loeb, Eui-Young So et al. LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans bioRxiv 12/15/2022 [PMID: 34845449] |
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| David A. Ostrov, Andrew P. Bluhm, Danmeng Li, Juveriya Qamar Khan, Megha Rohamare, Karthic Rajamanickam et al. Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells Pathogens 11/20/2021 [PMID: 34832669] |
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| Alessandro Villa, Electra Brunialti, Jessica Dellavedova, Clara Meda, Monica Rebecchi, Matteo Conti et al. DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic Pharmacological Research 1/1/2022 [PMID: 34798263] |
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| Khan M, Yoo SJ, Clijsters M et al. Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb Cell 11/1/2021 [PMID: 34798069] |
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| L Helms, S Marchiano, IB Stanaway, TY Hsiang, BA Juliar, S Saini, YT Zhao, A Khanna, R Menon, F Alakwaa, C Mikacenic, ED Morrell, MM Wurfel, M Kretzler, JL Harder, CE Murry, J Himmelfarb, H Ruohola-Ba, PK Bhatraju, M Gale, BS Freedman Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations JCI Insight, 2021-12-22;0(0):. 2021-12-22 [PMID: 34767537] (IHC, Human) |
IHC |
Human |
| L Nguyen, KA McCord, DT Bui, KM Bouwman, EN Kitova, M Elaish, D Kumawat, GC Daskhan, I Tomris, L Han, P Chopra, TJ Yang, SD Willows, AL Mason, LK Mahal, TL Lowary, LJ West, SD Hsu, T Hobman, SM Tompkins, GJ Boons, RP de Vries, MS Macauley, JS Klassen Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2 Nature Chemical Biology, 2021-11-09;0(0):. 2021-11-09 [PMID: 34754101] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| Qian Wang, Manoj S. Nair, Saumya Anang, Shijian Zhang, Hanh Nguyen, Yaoxing Huang et al. Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern iScience 11/19/2021 [PMID: 34746689] |
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| X Duan, X Tang, MS Nair, T Zhang, Y Qiu, W Zhang, P Wang, Y Huang, J Xiang, H Wang, RE Schwartz, DD Ho, T Evans, S Chen An airway organoid-based screen identifies a role for the HIF1alpha-glycolysis axis in SARS-CoV-2 infection Cell Reports, 2021-10-15;37(6):109920. 2021-10-15 [PMID: 34731648] (IHC, Human) |
IHC |
Human |
| Lilian Schimmel, Keng Yih Chew, Claudia J Stocks, Teodor E Yordanov, Patricia Essebier, Arutha Kulasinghe et al. Endothelial cells are not productively infected by SARS‐CoV‐2 Clinical & Translational Immunology 10/24/2021 [PMID: 34721846] |
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| Timothy Klouda, Yuan Hao, Hyunbum Kim, Jiwon Kim, Judith Olejnik, Adam J. Hume et al. Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2 Angiogenesis 5/1/2022 [PMID: 34714440] |
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| Xueyang Guo, Alexandra Kazanova, Stephanie Thurmond, H. Uri Saragovi, Christopher E. Rudd Effective chimeric antigen receptor T cells against SARS-CoV-2 iScience 11/19/2021 [PMID: 34693218] |
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| Mustafa M. Siddiq, Angel T. Chan, Lisa Miorin, Arjun S. Yadaw, Kristin G. Beaumont, Thomas Kehrer et al. Functional Effects of Cardiomyocyte Injury in COVID-19 Journal of Virology 1/26/2022 [PMID: 34669512] |
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| MW Ku, P Authié, M Bourgine, F Anna, A Noirat, F Moncoq, B Vesin, F Nevo, J Lopez, P Souque, C Blanc, I Fert, S Chardenoux, L Lafosse, D Cussigh, D Hardy, K Nemirov, F Guinet, F Langa Vive, L Majlessi, P Charneau Brain Cross-Protection against SARS-CoV-2 Variants by a Lentiviral Vaccine in New Transgenic Mice Embo Molecular Medicine, 2021-10-25;0(0):e14459. 2021-10-25 [PMID: 34647691] (Western Blot, Transgenic Mouse) |
Western Blot |
Transgenic Mouse |
| Nadine Krüger, Cheila Rocha, Sandra Runft, Johannes Krüger, Iris Färber, Federico Armando et al. The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection International Journal of Molecular Sciences 9/30/2021 [PMID: 34638978] |
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| S Singh, G Garcia, R Shah, AA Kramerov, RE Wright, TM Spektor, AV Ljubimov, V Arumugaswa, A Kumar SARS-CoV-2 and its variants of concern infect human conjunctival epithelial cells and induce differential antiviral innate immune response The ocular surface, 2021-09-25;0(0):. 2021-09-25 [PMID: 34583089] (ICC, IHC, Human) |
ICC, IHC |
Human |
| Joep Beumer, Maarten H. Geurts, Mart M. Lamers, Jens Puschhof, Jingshu Zhang, Jelte van der Vaart et al. A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses Nature Communications 9/17/2021 [PMID: 34535662] |
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| Hsu-Yu Chen, Chun Huang, Lu Tian, Xiaoli Huang, Chennan Zhang, George N. Llewellyn et al. Cytoplasmic Tail Truncation of SARS-CoV-2 Spike Protein Enhances Titer of Pseudotyped Vectors but Masks the Effect of the D614G Mutation Journal of Virology 10/27/2021 [PMID: 34495700] |
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| Parej Nath, Nishant Ranjan Chauhan, Kautilya Kumar Jena, Ankita Datey, Nilima Dinesh Kumar, Subhash Mehto et al. Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses EMBO reports 11/4/2021 [PMID: 34467632] |
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| SP Shukla, KB Cho, V Rustagi, X Gao, X Fu, SX Zhang, B Guo, DG Udugamasoo "Molecular Masks" for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry International Journal of Molecular Sciences, 2021-08-20;22(16):. 2021-08-20 [PMID: 34445669] (Flow Cytometry, Western Blot, Human) |
Flow Cytometry, Western Blot |
Human |
| Yuning Chen, Ya-Nan Zhang, Renhong Yan, Guifeng Wang, Yuanyuan Zhang, Zhe-Rui Zhang et al. ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker Signal Transduction and Targeted Therapy 8/25/2021 [PMID: 34433803] |
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| Orianne Constant, Jonathan Barthelemy, Karine Bolloré, Edouard Tuaillon, Fabien Gosselet, Christine Chable-Bessia et al. SARS-CoV-2 Poorly Replicates in Cells of the Human Blood-Brain Barrier Without Associated Deleterious Effects Frontiers in Immunology 7/27/2021 [PMID: 34386007] |
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| EJ Sherman, BT Emmer ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes Scientific Reports, 2021-08-05;11(1):15900. 2021-08-05 [PMID: 34354120] (Western Blot, Flow Cytometry, Human) |
Western Blot, Flow Cytometry |
Human |
| M Alenquer, F Ferreira, D Lousa, M Valério, M Medina-Lop, ML Bergman, J Gonçalves, J Demengeot, RB Leite, J Lilue, Z Ning, C Penha-Gonç, H Soares, CM Soares, MJ Amorim Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies PloS Pathogens, 2021-08-05;17(8):e1009772. 2021-08-05 [PMID: 34352039] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| Thomas L. Williams, Maria T. Colzani, Robyn G. C. Macrae, Emma L. Robinson, Stuart Bloor, Edward J. D. Greenwood et al. Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection Communications Biology 7/29/2021 [PMID: 34326460] |
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| Fengming Liu, Kun Han, Robert Blair, Kornelia Kenst, Zhongnan Qin, Berin Upcin et al. SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro Frontiers in Cellular and Infection Microbiology 7/6/2021 [PMID: 34307198] |
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| CLC Almeida-da, H Matshik Da, K Liu, DM Ojcius Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells International Journal of Molecular Sciences, 2021-07-18;22(14):. 2021-07-18 [PMID: 34299289] (ICC, Western Blot, Human) |
ICC, Western Blot |
Human |
| Y Kondo, JL Larabee, L Gao, H Shi, B Shao, CM Hoover, JM McDaniel, YC Ho, R Silasi-Man, SA Archer-Har, P Azadi, RS Srinivasan, AR Rezaie, A Borczuk, JC Laurence, F Lupu, J Ahamed, RP McEver, JF Papin, Z Yu, L Xia L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus JCI Insight, 2021-07-22;6(14):. 2021-07-22 [PMID: 34291736] (IHC, Human) |
IHC |
Human |
| Chen Dy, Khan N, Close Bj Et Al. SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway Journal of virology 7/14/2021 [PMID: 34260266] |
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| L Wang, D Sievert, AE Clark, S Lee, H Federman, BD Gastfriend, EV Shusta, SP Palecek, AF Carlin, JG Gleeson A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology Nature Medicine, 2021-07-09;0(0):. 2021-07-09 [PMID: 34244682] (IHC, Human) |
IHC |
Human |
| M Puray-Chav, KM LaPak, TP Schrank, JL Elliott, DP Bhatt, MJ Agajanian, R Jasuja, DQ Lawson, K Davis, PW Rothlauf, Z Liu, H Jo, N Lee, K Tenneti, JE Eschbach, C Shema Mugi, EM Cousins, EW Cloer, HR Vuong, LA VanBlargan, AL Bailey, P Gilchuk, JE Crowe, MS Diamond, DN Hayes, SPJ Whelan, A Horani, SL Brody, D Goldfarb, MB Major, SB Kutluay Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell Cell Reports, 2021-06-23;0(0):109364. 2021-06-23 [PMID: 34214467] (Western Blot, Human) |
Western Blot |
Human |
| Lynda J. Partridge, Lucy Urwin, Martin J. H. Nicklin, David C. James, Luke R. Green, Peter N. Monk ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin Cells 6/7/2021 [PMID: 34200372] |
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| Takahiko Toyonaga, Kenza C. Araba, Meaghan M. Kennedy, Benjamin P. Keith, Elisabeth A. Wolber, Caroline Beasley et al. Increased colonic expression of ACE2 associates with poor prognosis in Crohn’s disease Scientific Reports 6/29/2021 [PMID: 34188154] |
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| Pratik Adhikary, Sashi Kandel, Umar‐Farouk Mamani, Bahaa Mustafa, Siyuan Hao, Jianming Qiu et al. Discovery of Small Anti‐ACE2 Peptides to Inhibit SARS‐CoV‐2 Infectivity Advanced Therapeutics 7/1/2021 [PMID: 34179347] |
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| Jingwen Yue, Weihua Jin, Hua Yang, John Faulkner, Xuehong Song, Hong Qiu et al. Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer Frontiers in Molecular Biosciences 6/11/2021 [PMID: 34179075] |
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| Chihiro Motozono, Mako Toyoda, Jiri Zahradnik, Akatsuki Saito, Hesham Nasser, Toong Seng Tan et al. SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity Cell Host & Microbe 7/1/2021 [PMID: 34171266] |
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| M Zhao, PY Su, DA Castro, TN Tripler, Y Hu, M Cook, AI Ko, SF Farhadian, B Israelow, CS Dela Cruz, Y Xiong, RE Sutton, Yale IMPAC Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2 PloS Pathogens, 2021-06-24;17(6):e1009683. 2021-06-24 [PMID: 34166473] (Western Blot, Human) |
Western Blot |
Human |
| X Wang, CH Chen, S Badeti, JH Cho, A Naghizadeh, Z Wang, D Liu Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell-cell fusion Cell & bioscience, 2021-06-23;11(1):114. 2021-06-23 [PMID: 34162440] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| Ivo Djidrovski, Maria Georgiou, Grant L. Hughes, Edward I. Patterson, Aitor Casas-Sanchez, Shaun H. Pennington et al. SARS-CoV-2 infects an upper airway model derived from induced pluripotent stem cells Stem Cells 6/21/2021 [PMID: 34152044] |
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| C Steenblock, S Richter, I Berger, M Barovic, J Schmid, U Schubert, N Jarzebska, A von Mässen, A Linkermann, A Schürmann, J Pablik, T Dienemann, K Evert, RN Rodionov, NY Semenova, VA Zinserling, RR Gainetdino, G Baretton, D Lindemann, M Solimena, B Ludwig, SR Bornstein Viral infiltration of pancreatic islets in patients with COVID-19 Nature Communications, 2021-06-10;12(1):3534. 6/10/2021 [PMID: 34112801] |
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| Arthur Colson, Christophe L. Depoix, Géraldine Dessilly, Pamela Baldin, Olivier Danhaive, Corinne Hubinont et al. Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2 The American Journal of Pathology 9/1/2021 [PMID: 34111431] |
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| Tang X, Uhl S, Zhang T et al. SARS-CoV-2 infection induces beta cell transdifferentiation Cell Metabolism 5/1/2021 [PMID: 34081913] |
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| Rianna Vandergaast, Timothy Carey, Samantha Reiter, Chase Lathrum, Patrycja Lech, Clement Gnanadurai et al. IMMUNO-COV v2.0: Development and Validation of a High-Throughput Clinical Assay for Measuring SARS-CoV-2-Neutralizing Antibody Titers mSphere 6/30/2021 [PMID: 34077262] |
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| C Xu, A Wang, K Geng, W Honnen, X Wang, N Bruiners, S Singh, F Ferrara, S D'Angelo, ARM Bradbury, ML Gennaro, D Liu, A Pinter, TL Chang Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry Mechanisms Viruses, 2021-05-21;13(6):. 5/21/2021 [PMID: 34064066] |
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| M Baratchian, JM McManus, MP Berk, F Nakamura, S Mukhopadhy, W Xu, S Erzurum, J Drazba, J Peterson, EA Klein, B Gaston, N Sharifi Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes Scientific Reports, 2021-05-27;11(1):11130. 2021-05-27 [PMID: 34045511] (IHC, Mouse) |
IHC |
Mouse |
| T Ebisudani, S Sugimoto, K Haga, A Mitsuishi, R Takai-Toda, M Fujii, K Toshimitsu, J Hamamoto, K Sugihara, T Hishida, H Asamura, K Fukunaga, H Yasuda, K Katayama, T Sato Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening Cell Reports, 2021-05-19;0(0):109218. 2021-05-19 [PMID: 34038715] (ICC, Human) |
ICC |
Human |
| AZ Eriksen, R Møller, B Makovoz, SA Uhl, BR tenOever, TA Blenkinsop SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium Cell Stem Cell, 2021-05-17;0(0):. 2021-05-17 [PMID: 34022129] (IHC, Human) |
IHC |
Human |
| Mingming Han, Deepesh Pandey ZMPSTE24 Regulates SARS-CoV-2 Spike Protein–enhanced Expression of Endothelial PAI-1 American Journal of Respiratory Cell and Molecular Biology 9/1/2021 [PMID: 34003736] |
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| Concepció Marin, Valeria Tubita, Cristóbal Langdon, Mireya Fuentes, María Jesús Rojas‐Lechuga, Antonio Valero et al. ACE2 downregulation in olfactory mucosa: Eosinophilic rhinosinusitis as COVID‐19 protective factor? Allergy 9/1/2021 [PMID: 33987850] |
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| Jillian M. DiMuzio, Baron C. Heimbach, Raymond J. Howanski, John P. Dowling, Nirja B. Patel, Noeleya Henriquez et al. Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike protein Vaccine: X 8/1/2021 [PMID: 33937741] |
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| Santseharay Ramirez, Carlota Fernandez-Antunez, Andrea Galli, Alexander Underwood, Long V. Pham, Line A. Ryberg et al. Overcoming Culture Restriction for SARS-CoV-2 in Human Cells Facilitates the Screening of Compounds Inhibiting Viral Replication Antimicrobial Agents and Chemotherapy 6/17/2021 [PMID: 33903110] |
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| Li Wang, Xiaoyu Fan, Gaston Bonenfant, Dan Cui, Jaber Hossain, Nannan Jiang et al. Susceptibility to SARS-CoV-2 of Cell Lines and Substrates Commonly Used to Diagnose and Isolate Influenza and Other Viruses Emerging Infectious Diseases 5/1/2021 [PMID: 33900165] |
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| Yingshi Ouyang, Tarique Bagalkot, Wendy Fitzgerald, Elena Sadovsky, Tianjiao Chu, Ana Martínez-Marchal et al. Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin mSphere 4/28/2021 [PMID: 33853873] |
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| CH Chen, S Badeti, JH Cho, A Naghizadeh, X Wang, D Liu Deletion of ER-retention Motif on SARS-CoV-2 Spike Protein Reduces Cell Hybrid During Cell-cell Fusion Research square, 2021-04-09;0(0):. 2021-04-09 [PMID: 33851149] (Flow Cytometry, ICC, Human) |
Flow Cytometry, ICC |
Human |
| Elijah L. Mena, Callie J. Donahue, Laura Pontano Vaites, Jie Li, Gergely Rona, Colin O’Leary et al. ORF10–Cullin-2–ZYG11B complex is not required for SARS-CoV-2 infection Proceedings of the National Academy of Sciences 4/27/2021 [PMID: 33827988] |
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| M Dittmar, JS Lee, K Whig, E Segrist, M Li, B Kamalia, L Castellana, K Ayyanathan, FL Cardenas-D, EE Morrisey, R Truitt, W Yang, K Jurado, K Samby, H Ramage, DC Schultz, S Cherry Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2 Cell Reports, 2021-03-23;35(1):108959. 2021-03-23 [PMID: 33811811] (Western Blot, Human) |
Western Blot |
Human |
| Richard J. Mills, Sean J. Humphrey, Patrick R.J. Fortuna, Mary Lor, Simon R. Foster, Gregory A. Quaife-Ryan et al. BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection Cell 4/1/2021 [PMID: 33811809] |
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| SJ Dicken, MJ Murray, LG Thorne, AK Reuschl, C Forrest, M Ganeshalin, L Muir, MD Kalemera, M Palor, LE McCoy, C Jolly, GJ Towers, MB Reeves, J Grove Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2 bioRxiv : the preprint server for biology, 2021-03-22;0(0):. 2021-03-22 [PMID: 33791702] (Flow Cytometry, Western Blot, Human) |
Flow Cytometry, Western Blot |
Human |
| Yue Zhang, Guanglin Niu, Tatiana Flisikowska, Angelika Schnieke, Krzysztof Flisikowski A tissue- and gender-specific regulation of the SARS-CoV-2 receptor ACE2 by p53 in pigs Biochemical and Biophysical Research Communications 5/1/2021 [PMID: 33756342] |
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| Y Zhang, R Guo, SH Kim, H Shah, S Zhang, JH Liang, Y Fang, M Gentili, CNO Leary, SJ Elledge, DT Hung, VK Mootha, BE Gewurz SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication Nature Communications, 2021-03-15;12(1):1676. 2021-03-15 [PMID: 33723254] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| Maritza Puray-Chavez, Kyle M. LaPak, Travis P. Schrank, Jennifer L. Elliott, Dhaval P. Bhatt, Megan J. Agajanian et al. Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell bioRxiv 4/26/2023 [PMID: 33688646] |
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| J Baggen, L Persoons, E Vanstreels, S Jansen, D Van Loover, B Boeckx, V Geudens, J De Man, D Jochmans, J Wauters, E Wauters, BM Vanaudenae, D Lambrechts, J Neyts, K Dallmeier, HJ Thibaut, M Jacquemyn, P Maes, D Daelemans Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2 Nature Genetics, 2021-03-08;0(0):. 2021-03-08 [PMID: 33686287] (Flow Cytometry, Simple Western, Human) |
Flow Cytometry, Simple Western |
Human |
| K Uemura, M Sasaki, T Sanaki, S Toba, Y Takahashi, Y Orba, WW Hall, K Maenaka, H Sawa, A Sato MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2 Scientific Reports, 2021-03-08;11(1):5376. 2021-03-08 [PMID: 33686154] (Flow Cytometry, ICC, Human, Primate) |
Flow Cytometry, ICC |
Human, Primate |
| EE Khoury, Y Knaney, A Fokra, S Kinaneh, Z Azzam, SN Heyman, Z Abassi Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease Journal of Cellular and Molecular Medicine, 2021-03-04;0(0):. 2021-03-04 [PMID: 33660945] (IHC, Rat) |
IHC |
Rat |
| Michael S. Piepenbrink, Jun-Gyu Park, Fatai S. Oladunni, Ashlesha Deshpande, Madhubanti Basu, Sanghita Sarkar et al. Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters Cell Reports Medicine 3/1/2021 [PMID: 33649747] |
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| S Sugimoto, E Kobayashi, M Fujii, Y Ohta, K Arai, M Matano, K Ishikawa, K Miyamoto, K Toshimitsu, S Takahashi, K Nanki, Y Hakamata, T Kanai, T Sato An organoid-based organ-repurposing approach to treat short bowel syndrome Nature, 2021-02-24;0(0):. 2021-02-24 [PMID: 33627870] (IHC, Rat) |
IHC |
Rat |
| Sijia Zhao, Ting Xie, Li Shen, Hong Liu, Liling Wang, Xixiang Ma et al. An Immunological Perspective: What Happened to Pregnant Women After Recovering From COVID-19? Frontiers in Immunology 2/3/2021 [PMID: 33613576] |
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| Hornich BF, Grobkopf AK, Schlagowski S et al. SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation Journal of Virology 5/12/2021 [PMID: 33608407] |
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| H Huerga Enc, W Grey, M Garcia-Alb, H Wood, R Ulferts, IV Aramburu, AG Kulasekara, G Mufti, V Papayannop, R Beale, D Bonnet Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients Stem Cell Reports, 2021-02-05;16(3):428-436. 2021-02-05 [PMID: 33581053] (Flow Cytometry, ICC, Human) |
Flow Cytometry, ICC |
Human |
| Suresh V, Parida D, Minz A, Senapati S Tissue distribution of ACE2 protein in Syrian golden hamster (Mesocricetus auratus) and its possible implications in SARS-CoV-2 related studies Front Pharmacol 2/11/2021 [PMID: 33568991] |
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| Kim M. Bouwman, Ilhan Tomris, Hannah L. Turner, Roosmarijn van der Woude, Tatiana M. Shamorkina, Gerlof P. Bosman et al. Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins PLOS Pathogens 2/8/2021 [PMID: 33556147] |
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| Fanny Onodi, Lucie Bonnet-Madin, Laurent Meertens, Léa Karpf, Justine Poirot, Shen-Ying Zhang et al. SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4 Journal of Experimental Medicine 4/5/2021 [PMID: 33533916] |
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| Wysocki J, Ye M, Hassler L et al. A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids Journal of the American Society of Nephrology : JASN 2/1/2021 [PMID: 33526471] |
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| Jose Manuel Condor Capcha, Guerline Lambert, Derek M. Dykxhoorn, Alessandro G. Salerno, Joshua M. Hare, Michael A. Whitt et al. Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol Frontiers in Cardiovascular Medicine 1/15/2021 [PMID: 33521067] |
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| R Tian, AJ Samelson, VV Rezelj, M Chen, GN Ramadoss, X Guo, AM Kain, QD Tran, SA Lim, I Lui, J Nunez, SJ Rockwood, N Liu, J Carlson-St, J Oki, T Maures, K Holden, JS Weissman, JA Wells, B Conklin, M Vignuzzi, M Kampmann BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2 bioRxiv : the preprint server for biology, 2021-09-20;0(0):. 2021-09-20 [PMID: 33501440] (Western Blot, Human) |
Western Blot |
Human |
| F Onodi, L Bonnet-Mad, L Meertens, L Karpf, J Poirot, SY Zhang, C Picard, A Puel, E Jouanguy, Q Zhang, J Le Goff, JM Molina, C Delaugerre, JL Casanova, A Amara, V Soumelis SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4 bioRxiv : the preprint server for biology, 2021-01-08;0(0):. 2021-01-08 [PMID: 33442685] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
| X Yin, L Riva, Y Pu, L Martin-San, J Kanamune, Y Yamamoto, K Sakai, S Gotoh, L Miorin, PD De Jesus, CC Yang, KM Herbert, S Yoh, JF Hultquist, A García-Sas, SK Chanda MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells Cell Reports, 2021-01-12;34(2):108628. 2021-01-12 [PMID: 33440148] (ICC, Human) |
ICC |
Human |
| Song E, Zhang C, Israelow B et al. Neuroinvasion of SARS-CoV-2 in human and mouse brain Journal of Experimental Medicine 2021-03-01 [PMID: 33433624] |
|
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| Song E, Zhang C, Israelow B et al. Neuroinvasion of SARS-CoV-2 in human and mouse brain Journal of Experimental Medicine 3/1/2021 [PMID: 33433624] |
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| C Blume, CL Jackson, CM Spalluto, J Legebeke, L Nazlamova, F Conforti, JM Perotin, M Frank, J Butler, M Crispin, J Coles, J Thompson, RA Ridley, LSN Dean, M Loxham, S Reikine, A Azim, K Tariq, DA Johnston, PJ Skipp, R Djukanovic, D Baralle, CJ McCormick, DE Davies, JS Lucas, G Wheway, V Mennella A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection Nature Genetics, 2021-01-11;0(0):. 2021-01-11 [PMID: 33432184] (ICC, Human) |
ICC |
Human |
| H Chu, B Hu, X Huang, Y Chai, D Zhou, Y Wang, H Shuai, D Yang, Y Hou, X Zhang, TT Yuen, JP Cai, AJ Zhang, J Zhou, S Yuan, KK To, IH Chan, KY Sit, DC Foo, IY Wong, AT Ng, TT Cheung, SY Law, WK Au, MA Brindley, Z Chen, KH Kok, JF Chan, KY Yuen Host and viral determinants for efficient SARS-CoV-2 infection of the human lung Nature Communications, 2021-01-08;12(1):134. 2021-01-08 [PMID: 33420022] (Flow Cytometry, Hamster - Mesocricetus auratus (Golden Hamster)) |
Flow Cytometry |
Hamster - Mesocricetus auratus (Golden Hamster) |
| Kelly S. Schweitzer, Taylor Crue, Jordan M. Nall, Daniel Foster, Satria Sajuthi, Kelly A. Correll et al. Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells European Respiratory Journal 7/1/2021 [PMID: 33419885] |
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| AZ Mykytyn, TI Breugem, S Riesebosch, D Schipper, PB van den Do, RJ Rottier, MM Lamers, BL Haagmans SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site Elife, 2021-01-04;10(0):. 2021-01-04 [PMID: 33393462] (ICC, IHC, Human) |
ICC, IHC |
Human |
| Min-Wen Ku, Maryline Bourgine, Pierre Authié, Jodie Lopez, Kirill Nemirov, Fanny Moncoq et al. Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models Cell Host & Microbe 2/1/2021 [PMID: 33357418] |
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| Wang R, Simoneau CR, Kulsuptrakul J et al. Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses Cell 12/9/2020 [PMID: 33333024] |
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| Jian Zheng, Yuhang Wang, Kun Li, David K Meyerholz, Chantal Allamargot, Stanley Perlman Severe Acute Respiratory Syndrome Coronavirus 2–Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells The Journal of Infectious Diseases 3/3/2021 [PMID: 33277988] |
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| RM Samuel, H Majd, MN Richter, Z Ghazizadeh, SM Zekavat, A Navickas, JT Ramirez, H Asgharian, CR Simoneau, LR Bonser, KD Koh, M Garcia-Kni, M Tassetto, S Sunshine, S Farahvashi, A Kalantari, W Liu, R Andino, H Zhao, P Natarajan, DJ Erle, M Ott, H Goodarzi, F Fattahi Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell, 2020-11-17;27(6):876-889.e12. 2020-11-17 [PMID: 33232663] (ICC, Human) |
ICC |
Human |
| Kusmartseva I, Wu W, Syed F et al. Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19 Cell Metabolism 12/1/2020 [PMID: 33207244] |
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| Kusmartseva I, Wu W, Syed F et al. Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19 Cell Metabolism 2020-12-01 [PMID: 33207244] |
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IHC |
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Details:
Immunohistochemical analysis of lungs and brain tissue of K18 transgenic mice infected with SARS-CoV2 or C57BL/6J mice that had been injected with hACE2-expressing adenovirus. |
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Flow Cytometry |
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| T Azad, R Singaravel, MJF Crupi, T Jamieson, J Dave, EEF Brown, R Rezaei, Z Taha, S Boulton, NT Martin, A Surendran, J Poutou, M Ghahremani, K Nouri, JT Whelan, J Duong, S Tucker, JS Diallo, JC Bell, CS Ilkow Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization Membranes (Basel), 2020-08-30;10(9):. 2020-08-30 [PMID: 32872641] (Western Blot, Human) |
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| Elizabeth Taglauer, Yoel Benarroch, Kevin Rop, Elizabeth Barnett, Vishakha Sabharwal, Christina Yarrington et al. Consistent localization of SARS-CoV-2 spike glycoprotein and ACE2 over TMPRSS2 predominance in placental villi of 15 COVID-19 positive maternal-fetal dyads Placenta 10/1/2020 [PMID: 32862058] |
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Flow Cytometry |
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| IT Lee, T Nakayama, CT Wu, Y Goltsev, S Jiang, PA Gall, CK Liao, LC Shih, CM Schurch, DR McIlwain, P Chu, NA Borchard, D Zarabanda, SS Dholakia, A Yang, D Kim, T Kanie, CD Lin, MH Tsai, KM Phillips, R Kim, JB Overdevest, MA Tyler, CH Yan, CF Lin, YT Lin, DT Bau, GJ Tsay, ZM Patel, YA Tsou, CJ Tai, TH Yeh, PH Hwang, GP Nolan, JV Nayak, PK Jackson Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers medRxiv, 2020-05-12;0(0):. 2020-05-12 [PMID: 32511516] (IHC, Human) |
IHC |
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| Y Han, L Yang, X Duan, F Duan, BE Nilsson-Pa, TM Yaron, P Wang, X Tang, T Zhang, Z Zhao, Y Bram, D Redmond, S Houghton, D Nguyen, D Xu, X Wang, S Uhl, Y Huang, JL Johnson, J Xiang, H Wang, FC Pan, LC Cantley, BR tenOever, DD Ho, T Evans, RE Schwartz, HJ Chen, S Chen Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids bioRxiv, 2020-05-05;0(0):. 2020-05-05 [PMID: 32511403] (ICC, Human) |
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IHC, Western Blot |
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| J Zhou, C Li, X Liu, MC Chiu, X Zhao, D Wang, Y Wei, A Lee, AJ Zhang, H Chu, JP Cai, CC Yip, IH Chan, KK Wong, OT Tsang, KH Chan, JF Chan, KK To, H Chen, KY Yuen Infection of bat and human intestinal organoids by SARS-CoV-2 Nat. Med., 2020-05-13;0(0):. 2020-05-13 [PMID: 32405028] (ICC, Bat, Human) |
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| M Yang, X Ma, X Xuan, H Deng, Q Chen, L Yuan Liraglutide Attenuates Non-Alcoholic Fatty Liver Disease in Mice by Regulating the Local Renin-Angiotensin System Front Pharmacol, 2020-04-08;11(0):432. 2020-04-08 [PMID: 32322207] (Western Blot, Human, Mouse) |
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| Antonina Naskalska, Agnieszka Dabrowska, Artur Szczepanski, Aleksandra Milewska, Krzysztof Piotr Jasik, Krzysztof Pyrc Membrane Protein of Human Coronavirus NL63 Is Responsible for Interaction with the Adhesion Receptor Journal of Virology 10/1/2019 [PMID: 31315999] |
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IHC-P |
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| Hiroyuki Miyoshi, Kelli L VanDussen, Nicole P Malvin, Stacy H Ryu, Yi Wang, Naomi M Sonnek et al. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium The EMBO Journal 1/4/2017 [PMID: 27797821] |
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| Fengxia Xiao, Joseph Zimpelman, Dylan Burger, Christopher Kennedy, Richard L Hébert, Kevin D Burns Protein Kinase C-? Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells. Frontiers in Pharmacology, 2016-06-01;0(0):1663-9812. 2016-06-01 [PMID: 27313531] (Western Blot, Mouse) |
Western Blot |
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| Aleksandra Milewska HTCC: Broad Range Inhibitor of Coronavirus Entry PLoS ONE, 2016-06-01;11(6):e0156552. 2016-06-01 [PMID: 27249425] (IHC, Primate - Macaca mulatta (Rhesus Macaque)) |
IHC |
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| Yu Y, Chien S, Chen I, Lai C, Tsay Y, Chang S, Chang M Surface vimentin is critical for the cell entry of SARS-CoV. J Biomed Sci, 2016-01-22;23(1):14. 2016-01-22 [PMID: 26801988] (Neutralization, Primate - Chlorocebus pygerythrus (Vervet Monkey)) |
Neutralization |
Primate - Chlorocebus pygerythrus (Vervet Monkey) |
| Kim Brint Pedersen, Harshita Chodavarapu, Constance Porretta, Leonie K. Robinson, Eric Lazartigues Dynamics of ADAM17-Mediated Shedding of ACE2 Applied to Pancreatic Islets of Male db/db Mice Endocrinology 12/1/2015 [PMID: 26441236] |
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IHC |
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Flow Cytometry |
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| Ge , Xing-Yi, Li , Jia-Lu, Yang , Xing-Lou, Chmura , Aleksei, Zhu , Guangjia, Epstein , Jonathan, Mazet , Jonna K, Hu , Ben, Zhang , Wei, Peng , Cheng, Zhang , Yu-Ji, Luo , Chu-Ming, Tan , Bing, Wang , Ning, Zhu , Yan, Crameri , Gary, Zhang , Shu-Yi, Wang , Lin-Fa, Daszak , Peter, Shi , Zheng-Li Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature, 2013-10-30;503(7477):535-8. 2013-10-30 [PMID: 24172901] (IHC, Bat, Civet, Human) |
IHC |
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| Dirk Jochmans, Pieter Leyssen, Johan Neyts A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE Journal of Virological Methods 8/1/2012 [PMID: 22575574] |
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| Bertram S, Heurich A, Lavender H, Gierer S, Danisch S, Perin P, Lucas JM, Nelson PS, Pohlmann S, Soilleux EJ Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts. PLoS ONE, 2012-04-30;7(4):e35876. 2012-04-30 [PMID: 22558251] (IHC-P, Human) |
IHC-P |
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Western Blot |
Primate - Chlorocebus pygerythrus (Vervet Monkey) |
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| Epelman S, Tang WH, Chen SY, Van Lente F, Francis GS, Sen S Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system. J. Am. Coll. Cardiol., 2008-08-26;52(9):750-4. 2008-08-26 [PMID: 18718423] (Neutralization, Human) |
Neutralization |
Human |
| Lu Y, Liu DX, Tam JP Lipid rafts are involved in SARS-CoV entry into Vero E6 cells. Biochem. Biophys. Res. Commun., 2008-02-13;369(2):344-9. 2008-02-13 [PMID: 18279660] (Flow Cytometry, Primate - Chlorocebus pygerythrus (Vervet Monkey)) |
Flow Cytometry |
Primate - Chlorocebus pygerythrus (Vervet Monkey) |
| Ren W, Qu X, Li W, Han Z, Yu M, Zhou P, Zhang SY, Wang LF, Deng H, Shi Z Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin. J. Virol., 2007-12-12;82(4):1899-907. 2007-12-12 [PMID: 18077725] (ICC, Western Blot, Human) |
ICC, Western Blot |
Human |
| Inoue Y, Tanaka N, Tanaka Y, Inoue S, Morita K, Zhuang M, Hattori T, Sugamura K Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted. J. Virol., 2007-05-23;81(16):8722-9. 2007-05-23 [PMID: 17522231] (Western Blot, Primate - Macaca mulatta (Rhesus Macaque)) |
Western Blot |
Primate - Macaca mulatta (Rhesus Macaque) |
| Rockx B, Sheahan T, Donaldson E, Harkema J, Sims A, Heise M, Pickles R, Cameron M, Kelvin D, Baric R Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. J. Virol., 2007-05-16;81(14):7410-23. 2007-05-16 [PMID: 17507479] (Neutralization, Primate - Chlorocebus pygerythrus (Vervet Monkey)) |
Neutralization |
Primate - Chlorocebus pygerythrus (Vervet Monkey) |
| de Lang A, Osterhaus AD, Haagmans BL Interferon-gamma and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells. Virology, 2006-07-24;353(2):474-81. 2006-07-24 [PMID: 16860835] (ICC, Primate - Chlorocebus pygerythrus (Vervet Monkey)) |
ICC |
Primate - Chlorocebus pygerythrus (Vervet Monkey) |
| Tseng CT, Tseng J, Perrone L, Worthy M, Popov V, Peters CJ Apical entry and release of severe acute respiratory syndrome-associated coronavirus in polarized Calu-3 lung epithelial cells. J. Virol., 2005-08-01;79(15):9470-9. 2005-08-01 [PMID: 16014910] (ICC, Neutralization, Human) |
ICC, Neutralization |
Human |
| Hofmann H, Geier M, Marzi A, Krumbiegel M, Peipp M, Fey GH, Gramberg T, Pohlmann S Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. Biochem. Biophys. Res. Commun., 2004-07-09;319(4):1216-21. 2004-07-09 [PMID: 15194496] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
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Show All 293 Publications.
Collapse Publications.
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![Immunohistochemistry ACE/CD143 Antibody [Unconjugated]](https://images.novusbio.com/images2/ACE_AF1513_Immunohistochemistry_6703.jpg)
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![Simple Western: ACE-2 Antibody [Unconjugated] [AF933] - Design for a membrane-localized ACE2 expression system. (A) Our ACE2 construct is driven by a CMV promoter followed by the first 25 residues of ACE2 containing the leader sequence that direct ACE2 to the plasma membrane. This is followed by a 3xHA tag linked to the remainder of ACE2 (20-805) and a C-terminal sfGFP. Both 3xHA and sfGFP fusions are separated from ACE2 by flexible 3xGGGGS linkers. (B) The ACE2 fusion protein is designed to be embedded in the plasma membrane where it can perform extracellular carboxypeptidase-mediated metabolism and its levels can be detected by cell staining with antibodies to HA. (C) Lysates from untransfected or 3xHA-ACE2-sfGFP-transfected HEK293 cells were analyzed by automated Jess capillary immunoassay using antibodies to HA, GFP, and two ACE2 antibodies. (D) Confocal fluorescence microscopy of HEK cells transfected with 3xHA-ACE2-sfGFP and stained with HA and the nuclear stain DAPI. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/37644110), licensed under a CC-BY license. Not internally tested by R&D Systems.](http://images.novusbio.com/fullsize/af933_human-ace-2-ectodomain-affinity-purified-polyclonal-ab-30820241044556.jpg "Simple Western: ACE-2 Antibody [Unconjugated] [AF933] - Design for a membrane-localized ACE2 expression system. (A) Our ACE2 construct is driven by a CMV promoter followed by the first 25 residues of ACE2 containing the leader sequence that direct ACE2 to the plasma membrane. This is followed by a 3xHA tag linked to the remainder of ACE2 (20-805) and a C-terminal sfGFP. Both 3xHA and sfGFP fusions are separated from ACE2 by flexible 3xGGGGS linkers. (B) The ACE2 fusion protein is designed to be embedded in the plasma membrane where it can perform extracellular carboxypeptidase-mediated metabolism and its levels can be detected by cell staining with antibodies to HA. (C) Lysates from untransfected or 3xHA-ACE2-sfGFP-transfected HEK293 cells were analyzed by automated Jess capillary immunoassay using antibodies to HA, GFP, and two ACE2 antibodies. (D) Confocal fluorescence microscopy of HEK cells transfected with 3xHA-ACE2-sfGFP and stained with HA and the nuclear stain DAPI. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/37644110), licensed under a CC-BY license. Not internally tested by R&D Systems.")
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