Reactivity | HuSpecies Glossary |
Applications | Flow |
Clonality | Polyclonal |
Host | Goat |
Conjugate | Alexa Fluor 750 |
Conjugate | Catalog # | Availability | Size | Price |
---|---|---|---|---|
Alexa Fluor 350 | FAB933U-100UG | |||
Alexa Fluor 405 | FAB933V-100UG | |||
Alexa Fluor 488 | FAB933G-100UG | |||
Alexa Fluor 594 | FAB933T-100UG | |||
Alexa Fluor 647 | FAB933R-100UG | |||
Alexa Fluor 700 | FAB933N-100UG | |||
Allophycocyanin | FAB933A-100 | |||
Biotin | BAF933 | |||
Phycoerythrin | FAB933P-100 | |||
Unconjugated | AF933 | |||
Immunogen | Mouse myeloma cell line NS0-derived recombinant human ACE-2 Gln18-Ser740 Accession # Q9BYF1 |
Specificity | Detects human ACE-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human ACE is observed. |
Source | N/A |
Isotype | IgG |
Clonality | Polyclonal |
Host | Goat |
Purity Statement | Antigen Affinity-purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Storage | Protect from light. Do not freeze.
|
Buffer | Supplied in a saline solution containing BSA and Sodium Azide. |
ACE-2, also called ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family that also includes somatic and germinal ACE (1). Human ACE-2 has about 40% amino acid identity to the N- and C-terminal domains of human somatic ACE. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 mRNA is found at high levels in testis, kidney, and heart and at moderate levels in colon, small intestine, and ovary. Classical ACE inhibitors such as captopril and lisinopril do not inhibit ACE-2 activity. Novel peptide inhibitors of ACE-2 do not inhibit ACE activity (2). Genetic data from Drosophila, mice and rats show that ACE-2 is an essential regulator of heart function in vivo (3).
ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 (4, 5). The Human anti-ACE2 antibody (catalog # AF933) was used to block the variant SARS-CoV-2 and ACE2 interaction to elucidate viral transmission and potential therapeutic strategies. (5)
Secondary Antibodies |
Isotype Controls |
COVID-19 and metabolic dysregulation: SARS-CoV-2 injures human exocrine and endocrine pancreas Jamshed Arslan, Pharm D, PhD Humans rely on the pancreas for digesting food and generating energy from it. SARS-CoV-2-mediated damage to the exocrine pancreas is evident from the pancreatitis, pancreatic enlargeme... Read full blog post. |
COVID-19 and the Cardiovascular System: Observed complications and potential mechanisms By Victoria OsinskiThe outbreak of COVID-19 resulting from the transmission of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in many cases of illness typically manifesting in mi... Read full blog post. |
Read full blog post. |
Read full blog post. |
Tiny Antibodies (VHHs) from Llama Neutralize Respiratory Coronaviruses By Jamshed Arslan, Pharm. D., PhD. VHH Single Domain Antibodies vs Conventional AntibodiesThe immune system protects living organisms against harmful substances. B cells ward off infections by producing antibodies t... Read full blog post. |
Blocking SARS-CoV-2 Cell Entry: A potential Strategy Against COVID-19 Pandemic By Jamshed Arslan, Pharm. D., PhD. Coronaviruses are a family of enveloped RNA viruses. Some family members circulate in human populations, but others like severe acute respiratory syndrome coronavirus (SARS-CoV) ar... Read full blog post. |
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