ABCB11 Antibody

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. (provided by RefSeq)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 6 of 6.

Publications using NBP1-89319	Applications	Species
Shearn CT, Anderson AL, Devereaux MW et Al. Overexpression of TNF? in TNF?ARE+/- mice increases hepatic periportal inflammation and alters bile acid signaling in mice Hepatol Commun 2024-12-01 [PMID: 39585296]
Sticova E, Jirsa M, Pawlowska J. New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications. Canadian Journal of Gastroenterology and Hepatology 2018-07-26 [PMID: 30145122] (IF/IHC, Human)	IF/IHC	Human
Blackmore L, Knisely AS, Hartley JL et al. Polymorphisms in ABCB11 and ATP8B1 Associated with Development of Severe Intrahepatic Cholestasis in Hodgkin's Lymphoma. Journal of Clinical and Experimental Hepatology. 2012-01-01 [PMID: 25755490] (IF/IHC, Human)	IF/IHC	Human
Sambrotta M, Strautnieks S, Papouli E et al. Mutations in TJP2 cause progressive cholestatic liver disease. Nat Genet 2014-04-01 [PMID: 24614073]
L H, E S, V Z et al. Progressive familial intrahepatic cholestasis in adulthood: 0 years' follow-up Klin. Biochem. Metab. 2020-01-01 (IF/IHC, Human)	IF/IHC	Human
Sticova E, Jirsa M et al. New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications. Can J Gastroenterol Hepatol 2018-08-28 [PMID: 30148122] (IF/IHC, Human)	IF/IHC	Human

Array NBP1-89319

• ABCB11 Antibodies
• ABCB11 Protein