ABCB11 Products

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. (provided by RefSeq)

Bioinformatics

Entrez	8647 Human
Uniprot	O95342 Human
Product By Gene ID	8647
Alternate Names	ABC member 16, MDR/TAP subfamily ABC16 ATP-binding cassette sub-family B member 11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 bile salt export pump BSEP BSEPPFIC2 EC 3.6.3 EC 3.6.3.44 PFIC-2 PGY4 progressive familial intrahepatic cholestasis 2 sister p-glycoprotein SPGPBRIC2