CCR2 Products

Description

CCR2, or C C chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins (MCP1, MCP3, MCP4) which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of calcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV1 infection. CCR2 has two isoforms and has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen and thymus.

Bioinformatics

Entrez	1231 Human 12772 Mouse 60463 Rat 729230 Human
Uniprot	NP_001116513 Human NP_001116868 Human P41597 Human P51683 Mouse
Product By Gene ID	729230
Alternate Names	C-C chemokine receptor type 2 C-C CKR-2 CC-CKR-2CKR2B CCR-2 CCR2A CCR2B CD192 antigen CD192 chemokine (C-C motif) receptor 2 CKR2 CKR2A CMKBR2MGC111760 FLJ78302 MCP-1 receptor MCP-1-RMGC103828 MGC168006 Monocyte chemoattractant protein 1 receptor monocyte chemotactic protein 1 receptor

Research Areas for CCR2

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
GPCR
Immunology
Innate Immunity
Signal Transduction

Related CCR2 Blog Posts

Check out the latest blog posts on CCR2.

MCP1: One Chemoattractant that's Hard to Resist Monocyte Chemoattractant Protein (MCP1) is a potent monocyte attractant, is a member of the CC chemokine subfamily. MCP1 exerts its effects through binding to G-protein-coupled receptors on the surface of leukocytes targeted for activation and migrati...    Read more.

CCR2: Affecting Autoimmunity via MCP1 interactions CCR2, also known as CD192 (cluster of differentiation 192), is a chemokine receptor and is expressed by monocytes, activated T cells, B cells and natural killer cells. This protein is encoded by CCR2 gene in humans. CCR2 gene encodes two protein isofo...    Read more.

CCR2 or CD192 CCR2 is a receptor for several monocyte chemoattractant proteins (MCP1, MCP3, MCP4) that specifically govern monocyte chemotaxis. CCR2 transduces its downstream signals through increasing intracellular calcium ion levels. For example, MCP1 regulate...    Read more.

Rest in Peace: Is the Receptor Interacting Protein (RIP) Kinase-3 (RIPK3) a Protector or Offender? By Jamshed Arslan, Pharm. D., PhD. Receptor interacting protein kinases (RIPKs) in necroptosisDeath is perhaps inevitable. Cell death can be programed and immunologically silent (apoptosis), unprogrammed and inflamm...    Read more.

Read more CCR2 related blogs.