EZH2/KMT6 Antibody

EZH2 (histone methyltransferase enhancer of zeste homolog 2) is a member of polycomb group proteins, and together with embryonic ectoderm development protein and suppressor of Zeste (SUZ12), EZH2 forms the polycomb repressor complex 2 which plays an important role in variety of biological processes such as differentiation, maintainance of cellular identity and proliferation, and stem-cell plasticity. EZH2 contains histone methyltransferase activity and mediates transcriptional repression of target genes at chromatin level by catalyzing trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 is overexpressed in cancers of diverse origins that includes hematologic malignancies, urothelial/esophageal carcinoma, glioma, renal cell carcinoma, NSCLC, and colorectal, breast and hepatic cancer. Moreover, high expression of EZH2 has been linked to aggressive tumor formation/poor prognosis and EZH2 contributes to the metastasis through the downregulation of E-cadherin by mediating histone H3 methylation. Accordingly, inhibition of EZH2 expression results in significantly decreased cell proliferation and increased G2-M arrest.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Human	07/25/2014	View Summary Application Western Blot Sample Tested HeLa cell lysates Species Human

Array NB110-83976

• EZH2/KMT6 Antibodies
• EZH2/KMT6 ELISA Kits
• EZH2/KMT6 Lysate
• EZH2/KMT6 Proteins