Flow Cytometry: VE-Cadherin Antibody (BV13) [NBP1-43348] - Analysis using the Biotin conjugate of NBP1-43348. Staining of bEnd.3 cell line with 0.5 micrograms of Rat IgG1 k Isotype Control Biotin (blue histogram) or ...read more
Flow Cytometry: VE-Cadherin Antibody (BV13) [NBP1-43348] - Staining of bEnd.3 cell line with 0.5 ug of Rat IgG1 K Isotype Control Purified (open histogram) or 0.5 ug of AntiMouse CD144 (VE-Cadherin) Purified (filled ...read more
Alternate Names for VE-Cadherin Antibody (BV13) - BSA Free
7B4 antigen
7B4
cadherin 5, type 2 (vascular endothelium)
cadherin 5, type 2, VE-cadherin (vascular epithelium)
Cadherin-5
CD144 antigen
CD144
CDH5
endothelial-specific cadherin
FLJ17376
Vascular endothelial cadherin
VECadherin
VE-Cadherin
Background
The BV13 monoclonal antibody reacts with mouse VE-Cadherin (CD144). VE-Cadherin is a 120 kDa member of the type II Cadherin family, characterized by the presence of 5 extracellular cadherin domains (ECD), and anchored to the actin cytoskeleton through their cytoplasmic tail. VE-Cadherin mediates homophilic adhesion between neighbouring endothelial cells and is localized within specialized structures at cell-cell contacts, called adherens junctions. VE-Cadherin is expressed constitutively throughout the entire vasculature, and is required for numerous endothelial cell functions including migration, survival, contact-dependent growth inhibition and endothelial cell assembly into tubular structures. Furthermore, it is thought that VE-Cadherin+CD45- cells from the yolk sac or aorta-gonad-mesonephros (AGM) have the potential to give rise to hematopoietic cells.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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