u-Plasminogen Activator/Urokinase Antibody

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP2-20819

• u-Plasminogen Activator/Urokinase Antibodies
• u-Plasminogen Activator/Urokinase Antibody Pair
• u-Plasminogen Activator/Urokinase ELISA Kit
• u-Plasminogen Activator/Urokinase Kit
• u-Plasminogen Activator/Urokinase Lysate
• u-Plasminogen Activator/Urokinase Proteins
• u-Plasminogen Activator/Urokinase Proteins and Enzymes
• u-Plasminogen Activator/Urokinase ELISAs