TRF-1 Antibody (TRF-78) - BSA Free

TRF1 binds the double-stranded telomeric repeat sequence, TAGGG. TRF1 and TRF2 are key components of vertebrate telomeres and bind to double-stranded telomeric DNA as homodimers. Dimerization involves the TRF homology (TRFH) domain, which also mediates interactions with other telomeric proteins. Fairall et al. (2001) determined the crystal structures of the dimerization domains from human TRF1 and TRF2 at 2.9- and 2.2-angstrom resolution, respectively. Despite a modest sequence identity, the 2 TRFH domains have the same entirely alpha-helical architecture, resembling a twisted horseshoe. The dimerization interfaces feature unique interactions that prevent heterodimerization. Mutational analysis of TRF1 corroborated the structural data and underscored the importance of the TRFH domain in dimerization, DNA binding, and telomere localization.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-1701	Applications	Species
Betlej G, Zabek T, Lewinska A et al. RNA 5-methylcytosine status is associated with DNMT2/TRDMT1 nuclear localization in osteosarcoma cell lines Journal of Bone Oncology 2022-07-01 [PMID: 35942470] (ICC/IF, Human)	ICC/IF	Human
Deregowska A, Pepek M, Pruszczyk K et al. Differential Regulation of Telomeric Complex by BCR-ABL1 Kinase in Human Cellular Models of Chronic Myeloid Leukemia-From Single Cell Analysis to Next-Generation Sequencing Genes (Basel) 2020-09-29 [PMID: 33003326] (WB, Human)	WB	Human
Zhu, Q, Yasumoto, H, Tsai, R Y L. Nucleostemin Delays Cellular Senescence Negatively Regulates TRF1 Protein Stability, . 26, 9279-9290. 2006-01-01 [PMID: 17000763]

Array NB100-1701

• TRF-1 Antibodies
• TRF-1 ELISA Kits
• TRF-1 Lysate
• TRF-1 Proteins