TRAILR4/TNFRSF10D/DcR2 Antibody - BSA Free

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 3 applications: FLOW, Flow-CS, WB.

Showing Publications 1 - 10 of 20. Show All 20 Publications. Collapse Publications.

Publications using NBP1-76985	Applications	Species
Fang Y, Lu J, Wang X et al. HIF-1 alpha Mediates TRAIL-Induced Neuronal Apoptosis via Regulating DcR1 Expression Following Traumatic Brain Injury Front Cell Neurosci 2020-08-03 [PMID: 32848609] (WB, Rat)	WB	Rat
Gupta SC, Francis SK, Nair MS et al. Azadirone, a Limonoid Tetranortriterpene, Induces Death Receptors and Sensitizes Human Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) through a p53 Protein-independent Mechanism: EVIDENCE FOR THE ROLE OF THE ROS-ERK-CHOP-DEATH RECEPTOR PATHWAY. J Biol Chem 2013-11-08 [PMID: 24078627] (WB, Human)	WB	Human
Allen JE, Ferrini R, Dicker DT et al. Targeting TRAIL death receptor 4 with trivalent DR4 Atrimer complexes. Mol Cancer Ther. 2012-10-01 [PMID: 22802267] Details: Antibodies cited: 1. DR5 (IMG-120A): Flow (cell surface) 2. DR4 (IMG-141): Flow (cell surface, HCT116 cells), Supplementary Fig. 5. 3. DcR2 (IMG-121-1): WB (SW620 and HCT15 cells), Supplementary Fig. 4.
Nagane M, Shimizu S, Mori E et al. Predominant antitumor effects by fully human anti-TRAIL-receptor 2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo. Neuro Oncol. 2010-07-01 [PMID: 20511188] (WB, Human) Details: Products cited: 1. DcR2 (IMG-121-1): WB (human glioma cell lines), Fig 4B. 2. DcR1 (IMG-245-1): WB (human glioma cell lines), Fig 4B.	WB	Human
Taniguchi H, Yoshida T, Horinaka M et al. Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells. Cancer Res. 2008-11-01 [PMID: 18974136] (WB) Details: Products cited: 1. IMG-121 (DcR2): WB (human colon carcinoma SW480 cell line), Fig 3. 2. IMG-245 (DcR1): WB (human colon carcinoma SW480 cell line), Fig 3.	WB
Lunghi P, Giuliani N, Mazzera L et al. Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood. 2008-09-15 [PMID: 18583568] (WB, Human) Details: 1. p73 (IMG-246): WB (human myeloma cell lines (HMCLs) XG-6 and XG-1), Fig. 4Ci. 2. p73 (deltaNp73) [IMG-313A]: WB (HMCLs), Fig. 4Ai. 3. DcR2 (IMG-121): WB (HMCLs), Fig. 5A.	WB	Human
Zhang HY, Wang HQ, Liu HM et al. Regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by DJ-1 in thyroid cancer cells. Endocr Relat Cancer. 2008-06-01 [PMID: 18430896] (WB, Human) Details: WB (human thyroid cells).	WB	Human
Kawakubo T, Okamoto K, Iwata J et al. Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. Cancer Res. 2007-11-15 [PMID: 18006832] (WB) Details: Products cited: 1. IMG-121 (DcR2): WB (human prostate carcinoma cell lines), Fig. 4B. 2. IMG-245 (DcR1): WB (human prostate carcinoma cell lines), Fig. 4B.	WB
Liu X, Yue P, Khuri FR, Sun SY. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. 2005-10-15 [PMID: 16230375]
Poulaki V, Mitsiades CS, McMullan C et al. Human retinoblastoma cells are resistant to apoptosis induced by death receptors: role of caspase-8 gene silencing. Invest Ophthalmol Vis Sci. 2005-01-01 [PMID: 15623796]
Fan QL, Zou WY, Song LH et al. Synergistic antitumor activity of TRAIL combined with chemotherapeutic agents in A549 cell lines in vitro and in vivo. Cancer Chemother Pharmacol. 2005-02-01 [PMID: 15290100]
Koyama S. Flow cytometric measurement of tumor necrosis factor-related apoptosis-inducing ligand and its receptors in gastric epithelium and infiltrating mucosal lymphocytes in Helicobacter pylori-associated gastritis. J Gastroenterol Hepatol. 2003-07-01 [PMID: 12795746] (FLOW)	FLOW
Mitsiades CS, Mitsiades N, Poulaki V et al. Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene. 2002-08-22 [PMID: 12173037] (Flow-CS, Human) Details: Flow (cell surface): Human MM-1S cells either treated or untreated with IFG-1 and IL-6, Fig 3.	Flow-CS	Human
Poulaki V, Mitsiades CS, Kotoula V et al. Regulation of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in thyroid carcinoma cells. Am J Pathol. 2002-08-01 [PMID: 12163389]
Mitsiades N, Mitsiades CS, Poulaki V et al. Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells. Blood. 2002-03-15 [PMID: 11877293]
Koyama S, Koike N, Adachi S. Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor. J Cancer Res Clin Oncol [PMID: 11862476] Details: Used the Azide Free form of this antibody.
Mitsiades CS, Treon SP, Mitsiades N et al. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. Blood. 2001-08-01 [PMID: 11468181]
Basile JR, Zacny V, Munger K. The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein. J Biol Chem. 2001-06-22 [PMID: 11306566] (WB, Human) Details: WB DR5/Apo2/TRAIL-R2/TRAILR2/TRICK2/KILLER (IMG-120A) and DcR2/TRAIL-R4/TRUNDD (IMG-121). Human keratinocytes (HFK) cells expressing HPV-16 EF (human papillomavirus), Fig 6.	WB	Human
Mitsiades N, Poulaki V, Mitsiades C, Tsokos M. Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5. Cancer Res. 2001-03-15 [PMID: 11289151]
Mitsiades N, Poulaki V, Tseleni-Balafouta S et al. Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res. 2000-08-01 [PMID: 10945619]
Show All 20 Publications. Collapse Publications.

Array NBP1-76985

• TRAILR4/TNFRSF10D/DcR2 Antibodies
• TRAILR4/TNFRSF10D/DcR2 Antibody Pair
• TRAILR4/TNFRSF10D/DcR2 ELISA Kit
• TRAILR4/TNFRSF10D/DcR2 Lysate
• TRAILR4/TNFRSF10D/DcR2 Proteins
• TRAILR4/TNFRSF10D/DcR2 Proteins and Enzyme